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Review

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies

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Pages 33-45 | Received 18 Jun 2016, Accepted 30 Sep 2016, Published online: 14 Oct 2016

Keep up to date with the latest research on this topic with citation updates for this article.

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Chong Lu, Yikui Zhao, Yan Cao, Li Liu, Shanshan Wu, Dongbin Li, Shuang Liu, Shuyuan Xiao, Yafen Wei & Xinyu Li. (2021) MALAT1 Regulated mTOR-Mediated Tau Hyperphosphorylation by Acting as a ceRNA of miR144 in Hippocampus Cells Exposed to High Glucose. Clinical Interventions in Aging 16, pages 1185-1191.
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Fabio Di Domenico, Ilaria Zuliani & Antonella Tramutola. (2019) Shining a light on defective autophagy by proteomics approaches: implications for neurodegenerative illnesses. Expert Review of Proteomics 16:11-12, pages 951-964.
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Samin Davoody, Afsaneh Asgari Taei, Pariya Khodabakhsh & Leila Dargahi. (2023) mTOR signaling and Alzheimer's disease: What we know and where we are? . CNS Neuroscience & Therapeutics.
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Ya-Li Wang, Jian-Gang Wang, Shuling Guo, Fang-Li Guo, En-Jie Liu, Xin Yang, Bingyan Feng, Jian-Zhi Wang, Martin Vreugdenhil & Cheng-Biao Lu. (2023) Oligomeric β-Amyloid Suppresses Hippocampal γ-Oscillations through Activation of the mTOR/S6K1 Pathway. Aging and disease, pages 0.
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Kaylin Hwang, Rahil N. Vaknalli, Kwaku Addo-Osafo, Mariane Vicente & Keith Vossel. (2022) Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms. Frontiers in Aging Neuroscience 14.
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Shaobin Yang, Yaqin Du, Xiaoqian Zhao, Chendong Wu & Peng Yu. (2022) Reducing PDK1/Akt Activity: An Effective Therapeutic Target in the Treatment of Alzheimer’s Disease. Cells 11:11, pages 1735.
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Shuting Xu, Peng Yang, Kang Qian, Yixian Li, Qian Guo, Pengzhen Wang, Ran Meng, Jing Wu, Jinxu Cao, Yunlong Cheng, Minjun Xu & Qizhi Zhang. (2022) Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer's disease. Bioactive Materials 11, pages 300-316.
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Eugenio Barone, Fabio Di Domenico, Marzia Perluigi & D. Allan Butterfield. (2021) The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease. Free Radical Biology and Medicine 176, pages 16-33.
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Elham Razani, Atieh Pourbagheri-Sigaroodi, Ava Safaroghli-Azar, Anahita Zoghi, Mahsa Shanaki-Bavarsad & Davood Bashash. (2021) The PI3K/Akt signaling axis in Alzheimer’s disease: a valuable target to stimulate or suppress?. Cell Stress and Chaperones 26:6, pages 871-887.
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M. Perluigi, F. Di Domenico, E. Barone & D.A. Butterfield. (2021) mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder. Free Radical Biology and Medicine 169, pages 382-396.
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Namrata P. Nailwal & Gaurav M. Doshi. (2021) Role of intracellular signaling pathways and their inhibitors in the treatment of inflammation. Inflammopharmacology 29:3, pages 617-640.
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Yun Cao, Bingjin Liu, Weiqi Xu, Lin Wang, Fangxiao Shi, Na Li, Ying Lei, Jianzhi Wang, Qing Tian & Xinwen Zhou. (2020) Inhibition of mTORC1 improves STZ-induced AD-like impairments in mice. Brain Research Bulletin 162, pages 166-179.
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Tiffany J. Rios-Fuller, Melanie Mahe, Beth Walters, Dounia Abbadi, Sandra Pérez-Baos, Abhilash Gadi, John J. Andrews, Olga Katsara, C. Theresa Vincent & Robert J. Schneider. (2020) Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs). International Journal of Molecular Sciences 21:15, pages 5301.
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Olja Mijanović, Ana Branković, Anton V. Borovjagin, Denis V. Butnaru, Evgeny A. Bezrukov, Roman B. Sukhanov, Anastasia Shpichka, Peter Timashev & Ilya Ulasov. (2020) Battling Neurodegenerative Diseases with Adeno-Associated Virus-Based Approaches. Viruses 12:4, pages 460.
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Fabiana Novellino, Valeria Saccà, Annalidia Donato, Paolo Zaffino, Maria Francesca Spadea, Marco Vismara, Biagio Arcidiacono, Natalia Malara, Ivan Presta & Giuseppe Donato. (2020) Innate Immunity: A Common Denominator between Neurodegenerative and Neuropsychiatric Diseases. International Journal of Molecular Sciences 21:3, pages 1115.
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Zhonghua Wu, Zhengchen You, Peng Chen, Cheng Chen, Fei Chen, Jianhong Shen & Hui Xu. (2018) Matrine Exerts Antidepressant-Like Effects on Mice: Role of the Hippocampal PI3K/Akt/mTOR Signaling. International Journal of Neuropsychopharmacology 21:8, pages 764-776.
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Antonella Caccamo, Ramona Belfiore & Salvatore Oddo. (2018) RETRACTED: Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer's disease. Neurobiology of Aging 68, pages 1.
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Erin E. Congdon. (2018) Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease. Frontiers in Neuroscience 12.
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Alberto M. Martelli, Francesca Buontempo & James A. McCubrey. (2018) Drug discovery targeting the mTOR pathway. Clinical Science 132:5, pages 543-568.
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Jaume Folch, Miren Ettcheto, Oriol Busquets, Elena Sánchez-López, Rubén Castro-Torres, Ester Verdaguer, Patricia Manzine, Saghar Poor, María García, Jordi Olloquequi, Carlos Beas-Zarate, Carme Auladell & Antoni Camins. (2018) The Implication of the Brain Insulin Receptor in Late Onset Alzheimer’s Disease Dementia. Pharmaceuticals 11:1, pages 11.
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Dawei Xu, Yuyu Sun, Chengniu Wang, Hao Wang, Yingjie Wang, Wei Zhao, Guofeng Bao, Fei Wang, Zhiming Cui & Bo Jiang. (2018) Hippocampal mTOR signaling is required for the antidepressant effects of paroxetine. Neuropharmacology 128, pages 181-195.
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Fabio Di Domenico, Antonella Tramutola, Cesira Foppoli, Elizabeth Head, Marzia Perluigi & D. Allan Butterfield. (2018) mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia. Free Radical Biology and Medicine 114, pages 94-101.
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Haruhiro Higashida, Shin-ya Kamimura, Takeshi Inoue, Osamu Hori, Mohammad Saharul Islam, Olga Lopatina & Chiharu Tsuji. (2016) Cyclic ADP-ribose as an endogenous inhibitor of the mTOR pathway downstream of dopamine receptors in the mouse striatum. Journal of Neural Transmission 125:1, pages 17-24.
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