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ROCK as a therapeutic target for ischemic stroke

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Pages 1167-1177 | Received 24 Aug 2017, Accepted 19 Oct 2017, Published online: 30 Oct 2017

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Clara Steichen, Claude Hervé, Thierry Hauet & Nicolas Bourmeyster. (2022) Rho GTPases in kidney physiology and diseases. Small GTPases 13:1, pages 141-161.
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Brian Yu, Nikola Sladojevic, John E. Blair & James K. Liao. (2020) Targeting Rho-associated coiled-coil forming protein kinase (ROCK) in cardiovascular fibrosis and stiffening. Expert Opinion on Therapeutic Targets 24:1, pages 47-62.
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Articles from other publishers (34)

Eduardo Benarroch. (2023) What Is the Role of the Rho-ROCK Pathway in Neurologic Disorders?. Neurology 101:12, pages 536-543.
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Weizhuo Lu, Zhiwu Chen & Jiyue Wen. (2023) The role of RhoA/ROCK pathway in the ischemic stroke-induced neuroinflammation. Biomedicine & Pharmacotherapy 165, pages 115141.
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Weizhuo Lu & Jiyue Wen. (2023) H2S-RhoA/ROCK Pathway and Glial Cells in Axonal Remyelination After Ischemic Stroke. Molecular Neurobiology 60:9, pages 5493-5504.
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Robin W. Yeo, Olivia Y. Zhou, Brian L. Zhong, Eric D. Sun, Paloma Navarro Negredo, Surag Nair, Mahfuza Sharmin, Tyson J. Ruetz, Mikaela Wilson, Anshul Kundaje, Alexander R. Dunn & Anne Brunet. (2023) Chromatin accessibility dynamics of neurogenic niche cells reveal defects in neural stem cell adhesion and migration during aging. Nature Aging 3:7, pages 866-893.
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Guiyuan Liu, Yinliang Bai, Guangxian Leng, Hanwei Ma, Yin Kong, Liuqing Guo, Fahong Wu, Fengxian Wei, Yi Pang & Youcheng Zhang. (2023) Rhubarb Anthraquinones Ameliorates Inflammatory Lung Injury by Enhancing Alveolar Epithelium Tight Junction Proteins through RhoA/ROCK1 Signalling . Pharmacognosy Magazine 19:2, pages 359-370.
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Komal Thapa, Kumar Shivam, Heena Khan, Amarjot Kaur, Kamal Dua, Sachin Singh & Thakur Gurjeet Singh. (2023) Emerging Targets for Modulation of Immune Response and Inflammation in Stroke. Neurochemical Research 48:6, pages 1663-1690.
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Weizhuo Lu & Jiyue Wen. (2022) H2S-mediated inhibition of RhoA/ROCK pathway and noncoding RNAs in ischemic stroke. Metabolic Brain Disease 38:1, pages 163-176.
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Yiming Wang, Yuqing Zhang & Dingguo Zhang. 2022. Frontiers in Cardiovascular Drug Discovery: Volume 6. Frontiers in Cardiovascular Drug Discovery: Volume 6 54 101 .
Brian Yu, Afaf E.G. Osman, Nikola Sladojevic, Nicole Prabhu, Haw-Chih Tai, Daiqing Chen, Gerardo Perla, Linus Park, Richard A. Larson & James K. Liao. (2022) Involvement of Rho-Associated Coiled-Coil Containing Kinase (ROCK) in BCR-ABL1 Tyrosine Kinase Inhibitor Cardiovascular Toxicity. JACC: CardioOncology 4:3, pages 371-383.
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Meng Xue, Shuo Chen, Jiaojiao Xi, Qianjun Guan, Wei Chen, Yan Guo & Zhiwu Chen. (2022) Protection against Hypoxia-Reoxygenation Injury of Hippocampal Neurons by H2S via Promoting Phosphorylation of ROCK2 at Tyr722 in Rat Model. Molecules 27:14, pages 4567.
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Johannes Piepgras, Astrid Rohrbeck, Ingo Just, Stefan Bittner, Gudrun Ahnert-Hilger & Markus Höltje. (2022) Enhancement of Phosphorylation and Transport Activity of the Neuronal Glutamate Transporter Excitatory Amino Acid Transporter 3 by C3bot and a 26mer C3bot Peptide. Frontiers in Cellular Neuroscience 16.
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Brandon J. DeOre, Paul P. Partyka, Fan Fan & Peter A. Galie. (2022) CD44 mediates shear stress mechanotransduction in an in vitro blood‐brain barrier model through small GTPases RhoA and Rac1. The FASEB Journal 36:5.
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Qian Wang, Shu-Fang Zhao, Xia Xiao, Ya-Nan Liu, Xiu-Li Wang & Yun-Xia Du. (2021) Combined Treatment of Bone Marrow Mesenchymal Stem Cells and Fasudil Promotes Neurovascular Remodeling and Neurological Function Recovery in Ischemic Stroke. Applied Biochemistry and Biotechnology 194:2, pages 801-812.
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Qian Guo, Tingting Guo, Yuanyuan Sun & Tianrong Chen. (2021) Circ_HECTD1 regulates cerebral ischemia injury via mechanisms involving the regulation of let-7c-5p/ROCK1 axis. NeuroReport 33:1, pages 13-22.
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Lu Hong, Weidong Chen, Ling He, Hui Tan, Daiyin Peng, Guodong Zhao, Xiaoqian Shi, Lei Wang, Mingming Liu & Huihui Jiang. (2021) Effect of Naoluoxintong on the NogoA/RhoA/ROCK pathway by down-regulating DNA methylation in MCAO rats. Journal of Ethnopharmacology 281, pages 114559.
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Sandeep Appunni, Deepika Gupta, Muni Rubens, Venkataraghavan Ramamoorthy, Himanshu Narayan Singh & Vishnu Swarup. (2021) Deregulated Protein Kinases: Friend and Foe in Ischemic Stroke. Molecular Neurobiology 58:12, pages 6471-6489.
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Tetsu Kimura, Yuta Horikoshi, Chika Kuriyagawa & Yukitoshi Niiyama. (2021) Rho/ROCK Pathway and Noncoding RNAs: Implications in Ischemic Stroke and Spinal Cord Injury. International Journal of Molecular Sciences 22:21, pages 11573.
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Zhuqing Li & Kaitlin M. Bratlie. (2021) Effect of RGD functionalization and stiffness of gellan gum hydrogels on macrophage polarization and function. Materials Science and Engineering: C 128, pages 112303.
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Dequan Kong, Baoying Xie, Yuhang Li & Yaping Xu. (2021) PEA prevented early BBB disruption after cerebral ischaemic/reperfusion (I/R) injury through regulation of ROCK/MLC signaling. Biochemical and Biophysical Research Communications 566, pages 164-169.
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Tadeu L. Montagnoli, Jaqueline S. da Silva, Susumu Z. Sudo, Aimeé D. Santos, Gabriel F. Gomide, Mauro P. L. de Sá & Gisele Zapata-Sudo. (2021) ROCK Inhibition as Potential Target for Treatment of Pulmonary Hypertension. Cells 10:7, pages 1648.
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Hajime Takase & RobertW Regenhardt. (2021) Motor tract reorganization after acute central nervous system injury: a translational perspective. Neural Regeneration Research 16:6, pages 1144.
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Wendeng Xu, Ceshu Gao & Jian Wu. (2020) CD151 Alleviates Early Blood–Brain Barrier Dysfunction After Experimental Focal Brain Ischemia in Rats. Cellular and Molecular Neurobiology 41:1, pages 151-162.
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Atilla Engin & Ayse Basak Engin. 2021. Protein Kinase-mediated Decisions Between Life and Death. Protein Kinase-mediated Decisions Between Life and Death 259 283 .
Xue-wei Pan, Mei-juan Wang, Shuai-shuai Gong, Min-hui Sun, Yan Wang, Yuan-yuan Zhang, Fang Li, Bo-yang Yu & Jun-ping Kou. (2020) YiQiFuMai Lyophilized Injection ameliorates tPA-induced hemorrhagic transformation by inhibiting cytoskeletal rearrangement associated with ROCK1 and NF-κB signaling pathways. Journal of Ethnopharmacology 262, pages 113161.
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Fang Zhang, Shuo Chen, Ji-Yue Wen & Zhi-Wu Chen. (2020) 3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury via mitoprotection and inhibition of the RhoA/ROCK pathway. American Journal of Physiology-Cell Physiology 319:4, pages C720-C733.
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Yu Zhao, Jiehong Yang, Chang Li, Guoying Zhou, Haofang Wan, Zhishan Ding, Haitong Wan & Huifen Zhou. (2020) Role of the neurovascular unit in the process of cerebral ischemic injury. Pharmacological Research 160, pages 105103.
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Romain Menet, Sarah Lecordier & Ayman ElAli. (2020) Wnt Pathway: An Emerging Player in Vascular and Traumatic Mediated Brain Injuries. Frontiers in Physiology 11.
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Nikola Sladojevic, Brian Yu & James K. Liao. (2020) Regulator of G‐Protein Signaling 5 Maintains Brain Endothelial Cell Function in Focal Cerebral Ischemia. Journal of the American Heart Association 9:18.
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Laijun Song, Chunyu Zhu, Wenxin Zheng, Dan Lu, Hong Jiao, Rongbing Zhao & Zhonglei Bao. (2020) Computational systematic selectivity of the Fasalog inhibitors between ROCK-I and ROCK-II kinase isoforms in Alzheimer’s disease. Computational Biology and Chemistry 87, pages 107314.
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Armin Sami, Michael E. Selzer & Shuxin Li. (2020) Advances in the Signaling Pathways Downstream of Glial-Scar Axon Growth Inhibitors. Frontiers in Cellular Neuroscience 14.
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Farshad Abedi, A. Wallace Hayes, Russel Reiter & Gholamreza Karimi. (2020) Acute lung injury: The therapeutic role of Rho kinase inhibitors. Pharmacological Research 155, pages 104736.
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Limin Li, Xiaoli Lou, Kunlun Zhang, Fangping Yu, Yingchun Zhao & Ping Jiang. (2020) Hydrochloride fasudil attenuates brain injury in ICH rats. Translational Neuroscience 11:1, pages 75-86.
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Kumiko Tanabe, Akiko Kojima, Junko Tachi, Daiki Nakashima, Osamu Kozawa & Hiroki Iida. (2019) Limitation by Rho-kinase and Rac of transforming growth factor-β-induced interleukin-6 release from astrocytes. Neuroscience Letters 696, pages 191-196.
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Wenwen Si, Shanyu Ye, Zhenxing Ren, Xin Liu, Zimei Wu, Yi Li, Jianhong Zhou, Saixia Zhang, Yiwei Li, Rudong Deng & Dongfeng Chen. (2019) miR‑335 promotes stress granule formation to inhibit apoptosis by targeting ROCK2 in acute ischemic stroke. International Journal of Molecular Medicine.
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