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Expert Review of Neurotherapeutics Volume 19, 2019 - Issue 1
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Editorial

Therapeutic potential of rescuing protein O-GlcNAcylation in tau-related pathologies

Fabio Di DomenicoDepartment of Biochemical Sciences, Sapienza University of Rome, Rome, ItalyCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-2013-209XView further author information
ORCID Icon,
Chiara LanzillottaORCID Iconhttp://orcid.org/0000-0002-6883-7806View further author information
ORCID Icon &
Antonella TramutolaView further author information
Pages 1-3 | Received 18 Sep 2018, Accepted 23 Oct 2018, Published online: 30 Oct 2018

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Jose M. Bartolomé-Nebreda, Andrés A. Trabanco, Adriana Ingrid Velter & Peter Buijnsters. (2021) O-GlcNAcase inhibitors as potential therapeutics for the treatment of Alzheimer’s disease and related tauopathies: analysis of the patent literature. Expert Opinion on Therapeutic Patents 31:12, pages 1117-1154.
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Articles from other publishers (12)

Ana M. Matos, João Barros & Amélia P. Rauter. 2023. Carbohydrate‐Based Therapeutics. Carbohydrate‐Based Therapeutics 293 352 .
Sachin Kammula, Sulagna Tripathi, Ning Wang, Valina L. Dawson, Ted M. Dawson & Xiaobo Mao. (2023) Unraveling the tau puzzle: a review of mechanistic targets and therapeutic interventions to prevent tau pathology in Alzheimer’s disease. Ageing and Neurodegenerative Diseases 3:4.
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Shreya Gupta, Sanjay K. A. Jinka, Saugat Khanal, Neha Bhavnani, Fayez Almashhori, Jason Lallo, Amy Mathias, Yasmine Al‐Rhayyel, Danielle Herman, John G. Holden, Sheila M. Fleming & Priya Raman. (2023) Cognitive dysfunction and increased phosphorylated tau are associated with reduced O‐GlcNAc signaling in an aging mouse model of metabolic syndrome . Journal of Neuroscience Research 101:8, pages 1324-1344.
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Galina Limorenko & Hilal A. Lashuel. (2022) Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies. Chemical Society Reviews 51:2, pages 513-565.
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Eugenio Barone, Fabio Di Domenico, Marzia Perluigi & D. Allan Butterfield. (2021) The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease. Free Radical Biology and Medicine 176, pages 16-33.
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Xiaoyan Li, Zhengming Wu, Jing He, Yiting Jin, Chengyu Chu, Yun Cao, Fei Gu, Hongying Wang, Chenjian Hou, Xiuping Liu & Qiang Zou. (2021) OGT regulated O-GlcNAcylation promotes papillary thyroid cancer malignancy via activating YAP. Oncogene 40:30, pages 4859-4871.
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Ilaria Zuliani, Chiara Lanzillotta, Antonella Tramutola, Eugenio Barone, Marzia Perluigi, Serena Rinaldo, Alessio Paone, Francesca Cutruzzolà, Francesco Bellanti, Matteo Spinelli, Francesca Natale, Salvatore Fusco, Claudio Grassi & Fabio Di Domenico. (2021) High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer’s Disease Signatures. International Journal of Molecular Sciences 22:7, pages 3746.
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Junfeng Ma, Ci Wu & Gerald W. Hart. (2021) Analytical and Biochemical Perspectives of Protein O-GlcNAcylation. Chemical Reviews 121:3, pages 1513-1581.
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Ilaria Zuliani, Chiara Lanzillotta, Antonella Tramutola, Antonio Francioso, Sara Pagnotta, Eugenio Barone, Marzia Perluigi & Fabio Di Domenico. (2020) The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome. Neurotherapeutics 18:1, pages 340-363.
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Yoshiyuki Soeda & Akihiko Takashima. (2020) New Insights Into Drug Discovery Targeting Tau Protein. Frontiers in Molecular Neuroscience 13.
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Carlos M. Martínez-Viturro, Andrés A. Trabanco, Jordi Royes, Elena Fernández, Gary Tresadern, Juan A. Vega, Alcira del Cerro, Francisca Delgado, Aránzazu García Molina, Fulgencio Tovar, Paul Shaffer, Andreas Ebneth, Alexis Bretteville, Liesbeth Mertens, Marijke Somers, Jose M. Alonso & José M. Bartolomé-Nebreda. (2020) Diazaspirononane Nonsaccharide Inhibitors of O-GlcNAcase (OGA) for the Treatment of Neurodegenerative Disorders. Journal of Medicinal Chemistry 63:22, pages 14017-14044.
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Chiara Lanzillotta, Fabio Di Domenico, Marzia Perluigi & D. Allan Butterfield. (2019) Targeting Mitochondria in Alzheimer Disease: Rationale and Perspectives. CNS Drugs 33:10, pages 957-969.
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