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Expert Review of Neurotherapeutics Volume 19, 2019 - Issue 9: Women in Neurology
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Gut microbiota in ALS: possible role in pathogenesis?

Pamela A. McCombeCentre for Clinical Research, The University of Queensland, Brisbane, Australia;Wesley Medical Research, Level 8 East Wing, The Wesley Hospital, Brisbane, Australia;Department of Neurology, Royal Brisbane & Women’s Hospital, Brisbane, Australia;School of Medicine, The University of Queensland, Brisbane, AustraliaCorrespondence[email protected]
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Robert D. HendersonWesley Medical Research, Level 8 East Wing, The Wesley Hospital, Brisbane, Australia;Department of Neurology, Royal Brisbane & Women’s Hospital, Brisbane, Australia;School of Medicine, The University of Queensland, Brisbane, Australia;Queensland Brain Institute, The University of Queensland, Brisbane, AustraliaView further author information
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Aven LeeCentre for Clinical Research, The University of Queensland, Brisbane, AustraliaView further author information
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John D. LeeSchool of Biomedical Sciences, The University of Queensland, Brisbane, AustraliaView further author information
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Trent M. WoodruffSchool of Biomedical Sciences, The University of Queensland, Brisbane, AustraliaView further author information
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Restuadi RestuadiInstitute for Molecular Bioscience, The University of Queensland, Brisbane, AustraliaView further author information
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Allan McRaeInstitute for Molecular Bioscience, The University of Queensland, Brisbane, AustraliaView further author information
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Naomi R. WrayQueensland Brain Institute, The University of Queensland, Brisbane, Australia;Institute for Molecular Bioscience, The University of Queensland, Brisbane, AustraliaView further author information
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Shyuan NgoCentre for Clinical Research, The University of Queensland, Brisbane, Australia;Wesley Medical Research, Level 8 East Wing, The Wesley Hospital, Brisbane, Australia;Department of Neurology, Royal Brisbane & Women’s Hospital, Brisbane, Australia;Queensland Brain Institute, The University of Queensland, Brisbane, Australia;Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, AustraliaView further author information
&
Frederik J. SteynCentre for Clinical Research, The University of Queensland, Brisbane, Australia;Wesley Medical Research, Level 8 East Wing, The Wesley Hospital, Brisbane, Australia;Department of Neurology, Royal Brisbane & Women’s Hospital, Brisbane, Australia;Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, AustraliaORCID Iconhttps://orcid.org/0000-0002-4782-3608View further author information
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Pages 785-805 | Received 03 Nov 2018, Accepted 21 May 2019, Published online: 29 May 2019

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Aven Lee, Buddhika Jayakody Arachchige, Robert Henderson, David Pow, Sarah Reed, James Aylward & Pamela Ann McCombe. (2021) Elevated plasma levels of D-serine in some patients with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 22:3-4, pages 206-210.
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Shyuan T. Ngo, Restuadi Restuadi, Allan F. McCrae, Ruben P. Van Eijk, Fleur Garton, Robert D. Henderson, Naomi R. Wray, Pamela A. McCombe & Frederik J. Steyn. (2020) Progression and survival of patients with motor neuron disease relative to their fecal microbiota. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 21:7-8, pages 549-562.
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Pamela A. McCombe, Fleur C Garton, Matthew Katz, Naomi R Wray & Robert D Henderson. (2020) What do we know about the variability in survival of patients with amyotrophic lateral sclerosis?. Expert Review of Neurotherapeutics 20:9, pages 921-941.
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Bingbing Guo, Jingyi Zhang, Weihao Zhang, Feng Chen & Bin Liu. Gut microbiota-derived short chain fatty acids act as mediators of the gut–brain axis targeting age-related neurodegenerative disorders: a narrative review. Critical Reviews in Food Science and Nutrition 0:0, pages 1-22.
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Articles from other publishers (21)

Du Hong, Chi Zhang, Wenshuo Wu, Xiaohui Lu & Liping Zhang. (2023) Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis. Frontiers in Neurology 14.
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Zhenxiang Gong, Li Ba, Jiahui Tang, Yuan Yang, Zehui Li, Mao Liu, Chun Yang, Fengfei Ding & Min Zhang. (2023) Gut microbiota links with cognitive impairment in amyotrophic lateral sclerosis: A multi-omics study. The Journal of Biomedical Research 37:2, pages 125.
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Zoe Castles, Lauren Buckett, Leanne Jiang, Frederik J. Steyn & Shyuan T. Ngo. 2023. Diet and Nutrition in Neurological Disorders. Diet and Nutrition in Neurological Disorders 123 140 .
Sarika Yadav, Ashish Dwivedi, Anurag Tripathi & Amit Kumar Tripathi. (2022) Therapeutic potential of short-chain fatty acid production by gut microbiota in neurodegenerative disorders. Nutrition Research 106, pages 72-84.
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Ana Cristina Calvo, Inés Valledor-Martín, Laura Moreno-Martínez, Janne Markus Toivonen & Rosario Osta. (2022) Lessons to Learn from the Gut Microbiota: A Focus on Amyotrophic Lateral Sclerosis. Genes 13:5, pages 865.
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Mariana Dantas de Carvalho Vilar, Sancha Helena de Lima Vale, Eliane Lopes Rosado, Mário Emílio Teixeira Dourado Júnior, José Brandão-Neto & Lúcia Leite-Lais. (2022) Intestinal Microbiota and Sclerosis Lateral Amyotrophic. REVISTA CIÊNCIAS EM SAÚDE 12:1, pages 3-13.
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Saravana Babu Chidambaram, Musthafa Mohamed Essa, A.G. Rathipriya, Muhammed Bishir, Bipul Ray, Arehally M. Mahalakshmi, A.H. Tousif, Meena K. Sakharkar, Rajpal Singh Kashyap, Robert P. Friedland & Tanya M. Monaghan. (2022) Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle. Pharmacology & Therapeutics 231, pages 107988.
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Hanieh Nargeh, Fatemeh Aliabadi, Marjan Ajami & Hamidreza Pazoki-Toroudi. (2021) Role of Polyphenols on Gut Microbiota and the Ubiquitin-Proteasome System in Neurodegenerative Diseases. Journal of Agricultural and Food Chemistry 69:22, pages 6119-6144.
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Xiao-Le Wang, Si-Tong Feng, Zhen-Zhen Wang, Nai-Hong Chen & Yi Zhang. (2021) Role of mitophagy in mitochondrial quality control: Mechanisms and potential implications for neurodegenerative diseases. Pharmacological Research 165, pages 105433.
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Julia Casani-Cubel, María Benlloch, Claudia Emmanuela Sanchis-Sanchis, Raquel Marin, Jose María Lajara-Romance & Jose Enrique de la Rubia Orti. (2021) The Impact of Microbiota on the Pathogenesis of Amyotrophic Lateral Sclerosis and the Possible Benefits of Polyphenols. An Overview. Metabolites 11:2, pages 120.
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Rajka Maria Liscic, Antonella Alberici, Nigel John Cairns, Maurizio Romano & Emanuele Buratti. (2020) From basic research to the clinic: innovative therapies for ALS and FTD in the pipeline. Molecular Neurodegeneration 15:1.
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Eleni Christoforidou, Greig Joilin & Majid Hafezparast. (2020) Potential of activated microglia as a source of dysregulated extracellular microRNAs contributing to neurodegeneration in amyotrophic lateral sclerosis. Journal of Neuroinflammation 17:1.
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Kanmani Suganya & Byung-Soo Koo. (2020) Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions. International Journal of Molecular Sciences 21:20, pages 7551.
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Lu Chen, Yong Chen, Mingming Zhao, Lemin Zheng & Dongsheng Fan. (2020) Changes in the concentrations of trimethylamine N-oxide (TMAO) and its precursors in patients with amyotrophic lateral sclerosis. Scientific Reports 10:1.
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Sreyashi Chandra, Md. Tanjim Alam, Jhilik Dey, Baby C. Pulikkaparambil Sasidharan, Upasana Ray, Amit K. Srivastava, Sonu Gandhi & Prem P. Tripathi. (2020) Healthy Gut, Healthy Brain: The Gut Microbiome in Neurodegenerative Disorders. Current Topics in Medicinal Chemistry 20:13, pages 1142-1153.
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Bruno Tilocca, Luisa Pieroni, Alessio Soggiu, Domenico Britti, Luigi Bonizzi, Paola Roncada & Viviana Greco. (2020) Gut–Brain Axis and Neurodegeneration: State-of-the-Art of Meta-Omics Sciences for Microbiota Characterization. International Journal of Molecular Sciences 21:11, pages 4045.
Crossref
Pamela A. McCombe, John D. Lee, Trent M. Woodruff & Robert D. Henderson. (2020) The Peripheral Immune System and Amyotrophic Lateral Sclerosis. Frontiers in Neurology 11.
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Aven Lee, Buddhika Jayakody Arachchige, Sarah Reed, Robert Henderson, James Aylward & Pamela Ann McCombe. (2020) Plasma from some patients with amyotrophic lateral sclerosis exhibits elevated formaldehyde levels. Journal of the Neurological Sciences 409, pages 116589.
Crossref
Wenjun Xie, Jieying Gao, Rong Jiang, Xinrong Liu, Feng Lai, Yong Tang, Hong Xiao, Yan Jia & Qunhua Bai. (2020) Twice subacute MPTP administrations induced time-dependent dopaminergic neurodegeneration and inflammation in midbrain and ileum, as well as gut microbiota disorders in PD mice. NeuroToxicology 76, pages 200-212.
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Marwa M. El-Dalatony & Xiangkai Li. 2020. Gut Remediation of Environmental Pollutants. Gut Remediation of Environmental Pollutants 145 168 .
Claudia Figueroa-Romero, Kai Guo, Benjamin J. Murdock, Ximena Paez-Colasante, Christine M. Bassis, Kristen A. Mikhail, Kristen D. Raue, Matthew C. Evans, Ghislaine F. Taubman, Andrew J. McDermott, Phillipe D. O'Brien, Masha G. Savelieff, Junguk Hur & Eva L. Feldman. (2019) Temporal evolution of the microbiome, immune system, and epigenome with disease progression in ALS mice. Disease Models & Mechanisms.
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