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Incidence and implications of chemotherapy related hand-foot syndrome

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Pages 1625-1633 | Received 05 Dec 2015, Accepted 14 Sep 2016, Published online: 08 Oct 2016

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Yan Lou, Qian Wang, Jinqi Zheng, Xi Wang, Weiqin Jiang, Yi Zheng, Qingwei Zhao, Yunqing Qiu & Su Zeng. (2018) Identification of the Novel Capecitabine Metabolites in Capecitabine-Treated Patients with Hand-Foot Syndrome. Chemical Research in Toxicology 31:10, pages 1069-1079.
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Crossref
Francis H X Yap, Niamh O'Sullivan & Thomas A Delaney. (2018) Psoriasis aggravation due to capecitabine: A case study and review of the literature. Australasian Journal of Dermatology 59:3, pages e212-e213.
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Simona Dostalova, Hana Polanska, Marketa Svobodova, Jan Balvan, Olga Krystofova, Yazan Haddad, Sona Krizkova, Michal Masarik, Tomas Eckschlager, Marie Stiborova, Zbynek Heger & Vojtech Adam. (2018) Prostate-Specific Membrane Antigen-Targeted Site-Directed Antibody-Conjugated Apoferritin Nanovehicle Favorably Influences In Vivo Side Effects of Doxorubicin. Scientific Reports 8:1.
Crossref
Rashmi Advani & Danit Arad. (2018) Case Report: Non-infectious causes of palmoplantar rashes, what to consider. F1000Research 7, pages 46.
Crossref
Azael Freites-Martinez & Mario E. Lacouture. 2018. The MASCC Textbook of Cancer Supportive Care and Survivorship. The MASCC Textbook of Cancer Supportive Care and Survivorship 597 620 .
Sepideh Elyasi, Farzaneh Sadat Rezazadeh Shojaee, Abolghasem Allahyari & Gholamreza Karimi. (2017) Topical Silymarin Administration for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. Phytotherapy Research 31:9, pages 1323-1329.
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