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Expert Opinion on Drug Safety Volume 15, 2016 - Issue 12
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Original Research

Proton pump inhibitors and risk of Clostridium difficile infection: a multi-country study using sequence symmetry analysis

Elizabeth E RougheadQuality Use of Medicines and Pharmacy Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, AustraliaCorrespondence[email protected]
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Esther W ChanCentre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, Hong kongView further author information
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Nam-Kyong ChoiInstitute of Environmental Medicine, Medical Research Center, Seoul National University, Seoul, Korea;Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USAView further author information
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Jenna GriffithsMarketed Health Products Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, CanadaView further author information
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Xue-Mei JinDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, KoreaView further author information
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Joongyub LeeMedical Research Collaborating Centre, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, KoreaView further author information
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Michio KimuraDepartment of Medical Informatics, Hamamatsu University, School of Medicine, Shizuoka, JapanView further author information
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Tomomi KimuraMedical Affairs, Astellas Pharma Inc, Tokyo, JapanView further author information
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Kiyoshi KubotaDepartment of Pharmacoepidemiology, University of Tokyo Graduate School of Medicine, Tokyo, Japan;NPO Drug Safety Research Unit, Tokyo, JapanView further author information
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Edward Chia-Cheng LaiSchool of Pharmacy and Institute of Clinical Pharmacy and Pharmaceutical Sciences, Health Outcome Research Centre, National Cheng Kung University, Tainan, TaiwanView further author information
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Kenneth KC ManCentre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, Hong kongView further author information
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Tuan Anh NguyenQuality Use of Medicines and Pharmacy Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, AustraliaView further author information
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Nobuhiro OobaDepartment of Pharmacoepidemiology, University of Tokyo Graduate School of Medicine, Tokyo, JapanView further author information
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Byung-Joo ParkDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, KoreaView further author information
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Tsugumichi SatoNPO Drug Safety Research Unit, Tokyo, JapanView further author information
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Ju-Young ShinDepartment of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, CanadaView further author information
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TongTong WangMarketed Health Products Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, CanadaView further author information
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Ian CK WongCentre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, Hong kong;Research Department of Practice and Policy, UCL School of Pharmacy, London, EnglandView further author information
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Yea-Huei Kao YangSchool of Pharmacy and Institute of Clinical Pharmacy and Pharmaceutical Sciences, Health Outcome Research Centre, National Cheng Kung University, Tainan, TaiwanView further author information
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Nicole L PrattQuality Use of Medicines and Pharmacy Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, AustraliaView further author information
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Pages 1589-1595 | Received 29 Mar 2016, Accepted 14 Sep 2016, Published online: 27 Sep 2016

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Cheng-Yang Hsieh, Chien-Chou Su, Shih-Chieh Shao, Sheng-Feng Sung, Swu-Jane Lin, Yea-Huei Kao Yang & Edward Chia-Cheng Lai. (2019) Taiwan’s National Health Insurance Research Database: past and future. Clinical Epidemiology 11, pages 349-358.
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Evan Stuart Bradley, Emily Howe, Xun Wu & John P. Haran. (2019) Proton pump inhibitors and 180-day mortality in the elderly after Clostridium difficile treatment. Gut Pathogens 11:1.
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Thomas V. Riley & Tomomi Kimura. (2018) The Epidemiology of Clostridium difficile Infection in Japan: A Systematic Review. Infectious Diseases and Therapy 7:1, pages 39-70.
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Hazza Al Otaibi, Anwar E. Ahmed & Maha Alammari. (2017) Association between omeprazole use and Clostridium difficile infection among hospitalized patients: A case–control study of the Saudi population . Qatar Medical Journal 2017:2, pages 2.
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Jeffrey K. Aronson. (2016) Inhibiting the proton pump: mechanisms, benefits, harms, and questions. BMC Medicine 14:1.
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