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Original Research

Proton pump inhibitors therapy and the risk of pneumonia: a systematic review and meta‐analysis of randomized controlled trials and observational studies

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Pages 163-172 | Received 10 Nov 2018, Accepted 30 Jan 2019, Published online: 22 Feb 2019

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James P Franciosi, Edward B Mougey, Evan S Dellon, Carolina Gutierrez-Junquera, Sonia Fernandez-Fernandez, Rajitha D Venkatesh & Sandeep K Gupta. (2022) Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions. Journal of Asthma and Allergy 15, pages 281-302.
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Ahmed Al-Marhabi, Ahmed Hashem, Bader Faiyaz Zuberi, Charles Onyekwere, Imran Lodhi, Mohamed Mounir, Saad Alkhowaiter, Sameer Al Awadhi, Vasudevan G. Naidoo & Yasser Hamada. (2022) The views of African and Middle Eastern Gastroenterologists on the management of mild-to-moderate, non-erosive gastro-esophageal reflux disease (GERD). Expert Review of Gastroenterology & Hepatology 16:3, pages 217-233.
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Xiao-Yu Zhang, Tao Li, Haibing Wu, Yun Ling, Zhi-Ping Qian & Liang Chen. (2021) Analysis of the Effect of Proton-Pump Inhibitors on the Course of COVID-19. Journal of Inflammation Research 14, pages 287-298.
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Aitor Lanas-Gimeno, Gonzalo Hijos & Ángel Lanas. (2019) Proton pump inhibitors, adverse events and increased risk of mortality. Expert Opinion on Drug Safety 18:11, pages 1043-1053.
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Heli Järvinen, Anna-Maija Tolppanen & Sirpa Hartikainen. (2023) Risk factors of pneumonia in persons with and without Alzheimer’s disease: a matched cohort study. BMC Geriatrics 23:1.
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Naina Mohamed Pakkir Maideen. (2023) Adverse Effects Associated with Long-Term Use of Proton Pump Inhibitors. Chonnam Medical Journal 59:2, pages 115.
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Bokyung Kim, Jin-Hyung Jung, Kyungdo Han, Seungkyung Kang, Eunwoo Lee, Hyunsoo Chung, Sang Gyun Kim & Soo-Jeong Cho. (2023) Histamine-2 Receptor Antagonists and Proton Pump Inhibitors Are Associated With Reduced Risk of SARS-CoV-2 Infection Without Comorbidities Including Diabetes, Hypertension, and Dyslipidemia: A Propensity Score-Matched Nationwide Cohort Study. Journal of Korean Medical Science 38:13.
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Xiaoyi Gao, Zi Yi Shao, Noam Grysman & George T Grossberg. (2023) Proton Pump Inhibitor Use and Risk of Dementia in Older Adults: A Systematic Review. US Neurology 19:1, pages 21.
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Dorota Ksiądzyna & Adam Szeląg. (2023) The Proton Pump Inhibitors Use and COVID-19 from Prior to Vaccination Perspective: A Review. Digestive Diseases 41:3, pages 513-521.
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S. Bally, J. Cottin, M. C. Gagnieu, J. C. Lega, C. Verstuyft, S. Rheims, G. Lesca, M. Cucherat & Guillaume Grenet. (2022) Publication bias in pharmacogenetics of adverse reaction to antiseizure drugs: An umbrella review and a meta-epidemiological study. PLOS ONE 17:12, pages e0278839.
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T. E. Kugler, I. S. Malovichko, V. B. Gnilitskaya, A. L. Khristulenko & N. F. Yarovaya. (2022) Proton Pump Inhibitors in the COVID-19 Pandemic. The Russian Archives of Internal Medicine 12:4, pages 245-253.
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Shanna C. Trenaman, Austin Harding, Susan K. Bowles, Susan A. Kirkland & Melissa K. Andrew. (2022) A Prescribing Cascade of Proton Pump Inhibitors Following Anticholinergic Medications in Older Adults With Dementia. Frontiers in Pharmacology 13.
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Antonella Laria, Alfredo Maria Lurati, Gaetano Zizzo, Eleonora Zaccara, Daniela Mazzocchi, Katia Angela Re, Mariagrazia Marrazza, Paola Faggioli & Antonino Mazzone. (2022) Interstitial Lung Disease in Rheumatoid Arthritis: A Practical Review. Frontiers in Medicine 9.
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Yun-Han Wang, Henrik Svanström, Viktor Wintzell, Jonas F Ludvigsson & Björn Pasternak. (2022) Association between proton pump inhibitor use and risk of pneumonia in children: nationwide self-controlled case series study in Sweden. BMJ Open 12:4, pages e060771.
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Hong-Bae Kim, Jung-Ha Kim & Bethany J. Wolf. (2021) Acid suppressant use in association with incidence and severe outcomes of COVID-19: a systematic review and meta-analysis. European Journal of Clinical Pharmacology 78:3, pages 383-391.
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Terry Cheuk-Fung Yip, Francis Ka-Leung Chan, Grace Chung-Yan Lui, Vincent Wai-Sun Wong, Henry Lik-Yuen Chan, Sunny Hei Wong, Joyce Wing-Yan Mak, Siew-Chien Ng, David Shu-Cheong Hui & Grace Lai-Hung Wong. (2022) Use of Proton-Pump Inhibitor Is Not Associated with Adverse Clinical Outcomes in COVID-19 Patients: A Territory-Wide Cohort Study. GastroHep 2022, pages 1-13.
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Philip O. Katz, Kerry B. Dunbar, Felice H. Schnoll-Sussman, Katarina B. Greer, Rena Yadlapati & Stuart Jon Spechler. (2022) ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease. American Journal of Gastroenterology 117:1, pages 27-56.
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Anjan Dhar, Frances Maw, Helen Jane Dallal & Stephen Attwood. (2022) Side effects of drug treatments for gastro-oesophageal reflux disease: current controversies. Frontline Gastroenterology 13:1, pages 45-49.
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Yoon Duk Hong, Jeroen P. Jansen, John Guerino, Marc L. Berger, William Crown, Wim G. Goettsch, C. Daniel Mullins, Richard J. Willke & Lucinda S. Orsini. (2021) Comparative effectiveness and safety of pharmaceuticals assessed in observational studies compared with randomized controlled trials. BMC Medicine 19:1.
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Grazia Mazzeo, Luigi Aronne, Domenica Francesca Mariniello, Valentino Allocca, Maria Ilaria Palma, Francesco Saverio Cerqua, Carlo Iadevaia, Adriano Costigliola, Roberto Parrella, Andrea Bianco & Vanvitelli/Monaldi COVID Group. (2021) Which impact for proton pump inhibitors in SARS-COV-2 pneumonia. Monaldi Archives for Chest Disease.
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Lucien Roulet. (2021) A nationwide cohort study with propensity score matching. Gut 70:9, pages 1802-1803.
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Elizabeth M. Salvo, Nicole C. Ferko, Sarah B. Cash, Ailish Gonzalez & Peter J. Kahrilas. (2021) Umbrella review of 42 systematic reviews with meta‐analyses: the safety of proton pump inhibitors. Alimentary Pharmacology & Therapeutics 54:2, pages 129-143.
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Kun-Siang Huang, Bo-Lin Pan, Wei-An Lai, Pin-Jie Bin, Yao-Hsu Yang & Chia-Pei Chou. (2021) Could prokinetic agents protect long-term nasogastric tube-dependent patients from being hospitalized for pneumonia? A nationwide population-based case-crossover study. PLOS ONE 16:4, pages e0249645.
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Jan Homolak, Ivan Kodvanj & Vladimir Trkulja. (2021) An Additional Perspective on Proton Pump Inhibitors as Risk Factors for COVID-19. Clinical Drug Investigation 41:3, pages 287-289.
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Seung Won Lee, Eun Kyo Ha, Abdullah Özgür Yeniova, Sung Yong Moon, So Young Kim, Hyun Yong Koh, Jee Myung Yang, Su Jin Jeong, Sun Joon Moon, Joo Young Cho, In Kyung Yoo & Dong Keon Yon. (2021) Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching. Gut 70:1, pages 76-84.
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V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, A. A. Sheptulin, V. I. Simanenkov, T. L. Lapina, I. B. Khlynov, N. N. Dekhnich, O. D. Lopina, O. P. Alekseeva, N. V. Korochanskaya, M. F. Osipenko, P. V. Pavlov, S. S. Pirogov, G. N. Tarasova, Yu. P. Uspenskiy, D. N. Andreev & D. E. Rumyantseva. (2020) Deprescribing and Optimal Selection of Proton Pump Inhibitors (Contributions of the 26th United Russian Gastroenterology Week). Russian Journal of Gastroenterology, Hepatology, Coloproctology 30:6, pages 7-18.
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Timotius Ivan Hariyanto, Ignatius Bima Prasetya & Andree Kurniawan. (2020) Proton pump inhibitor use is associated with increased risk of severity and mortality from coronavirus disease 2019 (COVID-19) infection. Digestive and Liver Disease 52:12, pages 1410-1412.
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Sara Aleraij, Sultan Alhowti, Mazen Ferwana, Imad Abdulmajeed & Ibrahim Mohsen Mutawwam. (2020) Effect of proton pump inhibitors on bone mineral density: A systematic review and meta-analysis of observational studies. Bone Reports 13, pages 100732.
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Tae Jun Kim & Hyuk Lee. (2020) Clinical Significance of Changes in Gut Microbiome Associated with Use of Proton Pump Inhibitors. The Korean Journal of Helicobacter and Upper Gastrointestinal Research 20:3, pages 196-203.
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Vincenzo Savarino, Elisa Marabotto, Manuele Furnari, Fabiana Zingone, Patrizia Zentilin & Edoardo Savarino. (2020) Latest insights into the hot question of proton pump inhibitor safety – a narrative review. Digestive and Liver Disease 52:8, pages 842-852.
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Jerome R. Lechien, Jonathan M. Bock, Thomas L. Carroll & Lee M. Akst. (2020) Is empirical treatment a reasonable strategy for laryngopharyngeal reflux? A contemporary review. Clinical Otolaryngology 45:4, pages 450-458.
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Kate N. Wang, J. Simon Bell, Edwin C. K. Tan, Julia F. M. Gilmartin-Thomas, Michael J. Dooley & Jenni Ilomäki. (2019) Proton Pump Inhibitors and Infection-Related Hospitalizations Among Residents of Long-Term Care Facilities: A Case–Control Study. Drugs & Aging 36:11, pages 1027-1034.
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