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Expert Opinion on Drug Safety Volume 18, 2019 - Issue 4
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Review

An update on the safety of tacrolimus in kidney transplant recipients, with a focus on tacrolimus minimization

Thomas JouveService de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, CHU Grenoble-Alpes, Grenoble, France;Université Grenoble Alpes, Grenoble, FranceView further author information
,
Johan NobleService de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, CHU Grenoble-Alpes, Grenoble, France;Université Grenoble Alpes, Grenoble, FranceView further author information
,
Lionel RostaingService de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, CHU Grenoble-Alpes, Grenoble, France;Université Grenoble Alpes, Grenoble, FranceCorrespondence[email protected]
View further author information
&
Paolo MalvezziService de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, CHU Grenoble-Alpes, Grenoble, France;Université Grenoble Alpes, Grenoble, FranceView further author information
Pages 285-294 | Received 09 Jan 2019, Accepted 22 Mar 2019, Published online: 01 Apr 2019

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Rajat Garg & Anuj Garg. (2023) Tacrolimus loaded nanostructured lipid carriers using Moringa oleifera seed oil: design, optimization and in-vitro evaluations. Journal of Microencapsulation 0:0, pages 1-15.
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Fang Cheng, Qiang Li, Jinglin Wang, Zhendi Wang, Fang Zeng & Yu Zhang. (2022) Retrospective Analysis of the Risk Factors of Perioperative Bacterial Infection and Correlation with Clinical Prognosis in Kidney Transplant Recipients. Infection and Drug Resistance 15, pages 2271-2286.
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Articles from other publishers (26)

Lin Zhou, Yafei Hou, Xufeng Pan, Xue Wang, Haizhen Jin, Xiaohua Yang, Kefan Wang, Xuping Ding, Kai Wang, Minfang Zhu, Yan Pan, Weimin Wang & Liming Lu. (2023) Trichosanthin-derived peptide Tk-PQ attenuates immune rejection in mouse tracheal allotransplant model by suppressing PI3K-Akt and inducing type II immune polarization. International Immunopharmacology 125, pages 111081.
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Alexandra L. Degraeve, Laure B. Bindels, Vincent Haufroid, Serge Moudio, Lidvine Boland, Kevin‐Alexandre Delongie, Joseph P. Dewulf, Djamila Chaib Eddour, Michel Mourad & Laure Elens. (2023) Tacrolimus Pharmacokinetics is Associated with Gut Microbiota Diversity in Kidney Transplant Patients: Results from a Pilot Cross‐Sectional Study. Clinical Pharmacology & Therapeutics.
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Gregory Petrossian, Jorge Ortiz, Alejandro Chiodo Ortiz, Kathryn Addonizio, Alexander Hsiao, Rosy James, Naoru Koizumi, Sunil Patel & Robert Plews. (2023) Increased CMV disease and “severe” BK viremia with belatacept vs. sirolimus three-drug maintenance immunosuppression. Transplant Immunology 79, pages 101857.
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Xiaoqian Jiang, Xinxin Xu, Hua Kuang, Liqiang Liu, Liguang Xu, Aihua Qu & Chuanlai Xu. (2023) A gold-based immunochromatographic strip for the specific detection of tacrolimus in whole blood. Journal of Materials Chemistry B 11:20, pages 4464-4474.
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Kelsey Coffman, Neha Patel, Felicia Bartlett, Jessica Newman, Shikha Patel, Taylor Sprague, Nikhil Rao, Erika Andrade, Michael J. Casey, Vinayak Rohan, Derek DuBay & David Taber. (2023) Diabetes is a significant and independent predictor for tacrolimus immediate release and LCP‐tacrolimus conversion ratios. Clinical Transplantation 37:5.
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David J. Taber, Felicia Bartlett, Neha Patel, Taylor Sprague, Shikha Patel, Jessica Newman, Erika Andrade, Nikhil Rao, Maria Aurora Posadas Salas, Michael Casey, Derek Dubay & Vinayak Rohan. (2023) Impact of converting adult kidney transplant recipients with high tacrolimus variability from twice daily immediate release tacrolimus to once daily LCP‐Tacrolimus. Clinical Transplantation 37:5.
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Nikhil Rao, Taylor Carcella, Neha Patel, Felicia Bartlett, Maria Aurora Posadas, Michael Casey, Derek A. Dubay & David J. Taber. (2023) Impact of CYP3A5 genotype on de-novo LCP tacrolimus dosing and monitoring in kidney transplantation. Pharmacogenetics and Genomics 33:3, pages 59-65.
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Zhiwei Li, Jie Xiang, Shengmin Mei, Yue Wu & Yuan Xu. (2023) The effect of PINK1/Parkin pathway on glucose homeostasis imbalance induced by tacrolimus in mouse livers. Heliyon 9:4, pages e15536.
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V. Ram Peddi, Bradley Marder, Luis Gaite, Jose Oberholzer, Ryan Goldberg, Thomas Pearson, Harold Yang, Lisa Allamassey, Martin Polinsky & Richard N. Formica. (2023) Treatment of De Novo Renal Transplant Recipients With Calcineurin Inhibitor–free, Belatacept Plus Everolimus–based Immunosuppression. Transplantation Direct 9:2, pages e1419.
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Yi-Chang Zhao, Chen-Lin Xiao, Jing-Jing Hou, Jia-Kai Li, Bi-Kui Zhang, Xu-Biao Xie, Chun-Hua Fang, Feng-Hua Peng, Indy Sandaradura & Miao Yan. (2022) The Effect of Voriconazole on Tacrolimus in Kidney Transplantation Recipients: A Real-World Study. Pharmaceutics 14:12, pages 2739.
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Jun Xiao, Pei-cai Fu & Zhi-jun Li. (2022) Clinical and imaging analysis to evaluate the response of patients with anti-DPPX encephalitis to immunotherapy. BMC Neurology 22:1.
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Xiaoying He, Xi Yang, Xiaoting Yan, Mingzhu Huang, Zheng Xiang & Yan Lou. (2022) Individualized Dosage of Tacrolimus for Renal Transplantation Patients Based on Pharmacometabonomics. Molecules 27:11, pages 3517.
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Mengyu ZhangSoichiro Tajima, Tomohiro Shigematsu, Hiroshi Noguchi, Keizo Kaku, Akihiro TsuchimotoYasuhiro Okabe, Nobuaki Egashira & Ichiro Ieiri. (2022) Development and Validation of A Liquid Chromatography–Tandem Mass Spectrometry Method to Simultaneously Measure Tacrolimus and Everolimus Concentrations in Kidney Allograft Biopsies After Kidney Transplantation. Therapeutic Drug Monitoring 44:2, pages 275-281.
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Reyna Ester Callisaya Calani, Victor Manuel Barajas Valencia, Isidro Franco Alvarez & Horacio Márquez González. (2021) Changes in blood glucose level after renal transplantation in pediatrics: A study of risk factors of new‐onset diabetes after transplantation. Pediatric Transplantation 26:2.
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Yaseen Hussain & Haroon Khan. 2022. Encyclopedia of Infection and Immunity. Encyclopedia of Infection and Immunity 726 740 .
Fang Cheng, Qiang Li, Jinglin Wang, Fang Zeng & Yu Zhang. (2021) Effects and safety evaluation of Wuzhi Capsules combined with tacrolimus for the treatment of kidney transplantation recipients. Journal of Clinical Pharmacy and Therapeutics 46:6, pages 1636-1649.
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Huiwu Zhang, Xiuli Li, Haiping Xu, Fang Ran & Guoxia Zhao. (2021) Effect and safety evaluation of tacrolimus and tripterygium glycosides combined therapy in treatment of Henoch–Schönlein purpura nephritis. International Journal of Urology 28:11, pages 1157-1163.
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Zhaolin Chen, Xi Cheng, Liwen Zhang, Liqin Tang, Yan Fang, Hongxiao Chen, Lei Zhang & Aizong Shen. (2021) The impact of IL-10 and CYP3A5 gene polymorphisms on dose-adjusted trough blood tacrolimus concentrations in early post-renal transplant recipients. Pharmacological Reports 73:5, pages 1418-1426.
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Pan Kun-ming, Chen Can, Xu Qing, Wu Wei, Lv Qian-zhou & Li Xiao-yu. (2021) Calcineurin inhibitor–associated new-onset diabetes mellitus in chronic kidney disease treatment: a 4-year single-center cross-sectional study in China. European Journal of Clinical Pharmacology 77:7, pages 961-969.
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David J. TaberJason HirschAlison Keys, Zemin SuJohn W. McGillicuddy. (2021) Etiologies and Outcomes Associated With Tacrolimus Levels Out of a Typical Range That Lead to High Variability in Kidney Transplant Recipients. Therapeutic Drug Monitoring 43:3, pages 401-407.
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H.E. Braithwaite, D.R. Darley, J. Brett, R.O. Day & J.E. Carland. (2021) Identifying the association between tacrolimus exposure and toxicity in heart and lung transplant recipients: A systematic review. Transplantation Reviews 35:2, pages 100610.
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Jose Maria Portoles, Carlos Jimenez, Dario Janeiro, Maria O. Lopez-Oliva, Alvaro Ortega-Carrion, Daniel Blanquez, Luis Arribas, Carlos Gomez, Teresa Diez, Julio Pascual & Isabel Portero. (2021) The Immunobiogram, a Novel In Vitro Assay to Evaluate Treatment Resistance in Patients Receiving Immunosuppressive Therapy. Frontiers in Immunology 11.
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Katharina Willuweit, Alexandra Frey, Anne Hörster, Fuat Saner & Kerstin Herzer. (2020) Real-World Administration of Once-Daily MeltDose® Prolonged-Release Tacrolimus (LCPT) Allows for Dose Reduction of Tacrolimus and Stabilizes Graft Function Following Liver Transplantation. Journal of Clinical Medicine 10:1, pages 124.
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Sarah S. Alghanem, Moetaza M. Soliman, Ali A. Alibrahim, Osama Gheith, Ahmed S. Kenawy & Abdelmoneim Awad. (2020) Monitoring Tacrolimus Trough Concentrations During the First Year After Kidney Transplantation: A National Retrospective Cohort Study. Frontiers in Pharmacology 11.
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Qi Ling, Haitao Huang, Yuqiu Han, Chenzhi Zhang, Xueyou Zhang, Kangchen Chen, Li Wu, Ruiqi Tang, Zhipeng Zheng, Shusen Zheng, Lanjuan Li & Baohong Wang. (2020) The tacrolimus-induced glucose homeostasis imbalance in terms of the liver: From bench to bedside. American Journal of Transplantation 20:3, pages 701-713.
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Oleg Rummo, Mario Carmellini, Nassim Kamar, Antoine Durrbach, Christiane Mousson, Flavia Caputo, Zoltan Mathe, Maarten H. L. Christiaans, Dirk R. J. Kuypers, Jürgen Klempnauer, Swapneel Anaokar, Martin Hurst, Gbenga Kazeem, Nasrullah Undre & Frank Lehner. (2019) Long‐term, prolonged‐release tacrolimus‐based immunosuppression in de novo kidney transplant recipients: 5‐year prospective follow‐up of the ADHERE study patients . Transplant International 33:2, pages 161-173.
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