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Expert Opinion on Drug Safety Volume 18, 2019 - Issue 10
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Review

Risk-benefit balance assessment of SSRI antidepressant use during pregnancy and lactation based on best available evidence – an update

Céline J Fischer FumeauxClinic of Neonatology, Mother and Child department, Lausanne University Hospital, Lausanne, SwitzerlandView further author information
,
Mathilde Morisod HarariService of Child and Adolescent Psychiatry, Lausanne University Hospital, Lausanne, SwitzerlandView further author information
,
Etienne WeisskopfSchool of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Geneva, SwitzerlandView further author information
,
Chin B EapUnit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Lausanne University Hospital, Lausanne, SwitzerlandView further author information
,
Manuella EpineyDepartment of Gynecology and Obstetrics, Geneva University Hospital, Geneva, SwitzerlandView further author information
,
Yvan VialService of Obstetrics, Mother and Child department, Lausanne University Hospital, Lausanne, SwitzerlandView further author information
,
Chantal CsajkaSchool of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Geneva, SwitzerlandView further author information
,
Myriam Bickle GrazClinic of Neonatology, Mother and Child department, Lausanne University Hospital, Lausanne, SwitzerlandView further author information
&
Alice PanchaudSchool of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Geneva, Switzerland;Pharmacy Service, Department of interdisciplinary centers, Lausanne University Hospital, Lausanne, SwitzerlandCorrespondence[email protected]
View further author information
 show all
Pages 949-963 | Received 21 Jun 2019, Accepted 19 Aug 2019, Published online: 09 Sep 2019

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Zhuoyue Wang, Hui Li, Yimin Kang, Yanlong Liu, Ligang Shan & Fan Wang. (2022) Risks of Digestive System Side-Effects of Selective Serotonin Reuptake Inhibitors in Patients with Depression: A Network Meta-Analysis. Therapeutics and Clinical Risk Management 18, pages 799-812.
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GERRI R. BAER, RACHANA SINGH & JONATHAN M. DAVIS. 2024. Avery's Diseases of the Newborn. Avery's Diseases of the Newborn 106 122.e6 .
Vanessa M. Oddo, Crussie Moise, Lauren Welke, Beatriz Peñalver Bernabé, Pauline Maki, Mary Dawn Koenig, Lacey Pezley, Yinglin Xia & Lisa Tussing-Humphreys. (2023) Mediterranean Diet Adherence and Depressive Symptoms among a Nationally Representative Sample of Pregnant Women in the United States. The Journal of Nutrition 153:10, pages 3041-3048.
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Rafael R Domingues, Milo C Wiltbank & Laura L Hernandez. (2023) Maternal serotonin: implications for the use of selective serotonin reuptake inhibitors during gestation. Biology of Reproduction 109:1, pages 17-28.
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Chun Hung, Joe Kwun Nam Chan, Corine Sau Man Wong, Vivian Shi Cheng Fung, Krystal Chi Kei Lee & Wing Chung Chang. (2022) Antidepressant utilization patterns and predictors of treatment continuation in pregnant women: A 16-year population-based cohort. Australian & New Zealand Journal of Psychiatry 57:5, pages 686-697.
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Ana Flávia Quiarato Lozano, Mayara Silva Moura, Taís Raquel Batisoco Dinhani, Lethícia Valencise & Wilma De Grava Kempinas. (2023) Is lactational sertraline exposure safe for maternal health and the reproductive/neurobehavioral development of the descendants? A study in rats. Reproductive Toxicology 117, pages 108356.
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Kristen M Krysko, Ruth Dobson, Raed Alroughani, Maria Pia Amato, Riley Bove, Andrea I Ciplea, Yara Fragoso, Maria Houtchens, Vilija G Jokubaitis, Melinda Magyari, Azza Abdelnasser, Vasantha Padma, Sandra Thiel, Mar Tintore, Sandra Vukusic & Kerstin Hellwig. (2023) Family planning considerations in people with multiple sclerosis. The Lancet Neurology 22:4, pages 350-366.
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Ayala Gover, Kareen Endrawes, Michal Molad, Karen Lavie-Nevo & Arieh Riskin. (2023) The Effect of SSRI Exposure in Pregnancy on Early Respiratory and Metabolic Adaptation in Infants Born Preterm. Children 10:3, pages 508.
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Pierre Desaunay, Léa-Gabrielle Eude, Michel Dreyfus, Cénéric Alexandre, Sophie Fedrizzi, Joachim Alexandre, Faruk Uguz & Fabian Guénolé. (2023) Benefits and Risks of Antidepressant Drugs During Pregnancy: A Systematic Review of Meta-analyses. Pediatric Drugs.
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Anna Linda Leutritz, Lara van Braam, Katharina Preis, Andrea Gehrmann, Maike Scherf‐Clavel, Katrin Fiedler, Stefan Unterecker & Sarah Kittel‐Schneider. (2022) Psychotropic medication in pregnancy and lactation and early development of exposed children. British Journal of Clinical Pharmacology 89:2, pages 737-750.
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Julie A. Vignato, S. Banu Gumusoglu, Heather A. Davis, Sabrina M. Scroggins, Wendy S. Hamilton, Debra S. Brandt, Gary L. Pierce, Boyd A. Knosp, Donna A. Santillan & Mark K. Santillan. (2022) Selective Serotonin Reuptake Inhibitor Use in Pregnancy and Protective Mechanisms in Preeclampsia. Reproductive Sciences 30:2, pages 701-712.
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Karina Bravo, Marcelo González-Ortiz, Sebastian Beltrán-Castillo, Daniela Cáceres & Jaime Eugenín. 2023. Advances in Maternal-Fetal Biomedicine. Advances in Maternal-Fetal Biomedicine 179 198 .
Maria Muzik, Samantha Shaw, Sophie Grigoriadis, Kristina M. Deligiannidis, Angelika Wieck, Prabha S. Chandra, Manisha Murugesan, Cara Anne Poland & Nancy Renn-Bugai. 2020. Tasman’s Psychiatry. Tasman’s Psychiatry 1 37 .
Dawei Li. (2022) Treatment of depression from both biological and psychological aspects. Treatment of depression from both biological and psychological aspects.
Jeffrey Wald, Anja Henningsson, Eva Hanze, Ethan Hoffmann, Haihong Li, Helen Colquhoun & Kristina M. Deligiannidis. (2022) Allopregnanolone Concentrations in Breast Milk and Plasma from Healthy Volunteers Receiving Brexanolone Injection, With Population Pharmacokinetic Modeling of Potential Relative Infant Dose. Clinical Pharmacokinetics 61:9, pages 1307-1319.
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Rahel Baumgartner, Ursula Winterfeld, Alice Panchaud & Ana Paula Simões-Wüst. (2022) Queries on medication use during pregnancy: characterisation of the Swiss Teratogen Information Service database. Swiss Medical Weekly 152:2122, pages w30187.
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Laurel A. Copeland, Rebecca L. KinneyAimee R. Kroll-DesrosiersGeetha ShivakumarKristin M. Mattocks. (2022) Medications with Potential for Fetal Risk Prescribed to Veterans. Journal of Women's Health.
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Luke E. Grzeskowiak, Moni R. Saha, Hedvig Nordeng, Eivind Ystrom & Lisa H. Amir. (2022) Perinatal antidepressant use and breastfeeding outcomes: Findings from the Norwegian Mother, Father and Child Cohort Study. Acta Obstetricia et Gynecologica Scandinavica 101:3, pages 344-354.
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Nadia T Evans, Nicholas Williams, Varan Perananthan, William Lugg, Andrew H Dawson & David A Osborn. (2021) Neonatal serotonin toxicity. Journal of Paediatrics and Child Health 58:1, pages 189-190.
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Fiona L. Challacombe & Megan A. Jansen. 2022. Clinical Guide to Exposure Therapy. Clinical Guide to Exposure Therapy 201 218 .
Gianluca Rosso & Giuseppe Maina. 2022. Key Topics in Perinatal Mental Health. Key Topics in Perinatal Mental Health 79 92 .
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Sarah Donald, Katrina Sharples, Dave Barson, Simon Horsburgh & Lianne Parkin. (2021) Antidepressant dispensing before, during, and after pregnancy in New Zealand, 2005‒2014. Australian and New Zealand Journal of Obstetrics and Gynaecology 61:6, pages 837-845.
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Cássio Prinholato da Silva, Denise Dias Oliveira, Bruno Iglesias Benincasa, Bruna Barbar, Ana Lúcia Facchin & Rene Oliveira Beleboni. (2021) Antidepressant activity of Riparin A in murine model. Behavioural Pharmacology 32:7, pages 599-606.
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Barbara Marie Alba. (2021) CE: Postpartum Depression: A Nurse's Guide. AJN, American Journal of Nursing 121:7, pages 32-43.
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Bin Chao, Lili Zhang, Juhua Pan, Ying Zhang, Yuxia Chen, Manman Xu & Shijing Huang. (2021) Stanniocalcin-1 Overexpression Prevents Depression-Like Behaviors Through Inhibition of the ROS/NF-κB Signaling Pathway. Frontiers in Psychiatry 12.
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Or Burstein, Noam Simon, Yaarit Simchon-Tenenbaum, Moshe Rehavi, Motty Franko, Alon Shamir & Ravid Doron. (2021) Moderation of the transgenerational transference of antenatal stress-induced anxiety. Translational Psychiatry 11:1.
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О.Р. Айзберг. (2021) Diagnosis and Treatment of Postpartum Depression. Психиатрия, психотерапия и клиническая психология:1, pages 116-123.
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Sheng-Min Wang, Won-Myong Bahk, Young Sup Woo, Jeong Seok Seo, Young-Min Park, Won Kim, Jong-Hyun Jeong, Se-Hoon Shim, Jung Goo Lee, Seung-Ho Jang, Chan-Mo Yang, Myung Hun Jung, Hyung Mo Sung, IL Han Choo, Bo-Hyun Yoon, Sang-Yeol Lee, Duk-In Jon & Kyung Joon Min. (2021) Korean Medication Algorithm Project for Depressive Disorder 2021 (IV): Female and Elderly. Journal of Korean Neuropsychiatric Association 60:4, pages 258.
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Gerd Laux. 2020. NeuroPsychopharmacotherapy. NeuroPsychopharmacotherapy 1 13 .
Sabrina I. Hanswijk, Marcia Spoelder, Ling Shan, Michel M. M. Verheij, Otto G. Muilwijk, Weizhuo Li, Chunqing Liu, Sharon M. Kolk & Judith R. Homberg. (2020) Gestational Factors throughout Fetal Neurodevelopment: The Serotonin Link. International Journal of Molecular Sciences 21:16, pages 5850.
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Neesha Hussain-Shamsy, Amika Shah, Simone N Vigod, Juveria Zaheer & Emily Seto. (2020) Mobile Health for Perinatal Depression and Anxiety: Scoping Review. Journal of Medical Internet Research 22:4, pages e17011.
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