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Expert Opinion on Drug Safety Volume 19, 2020 - Issue 12
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Review

Hedgehog inhibitors in the treatment of advanced basal cell carcinoma: risks and benefits

Alessia Villania Dermatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, ItalyCorrespondence[email protected]
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,
Eleonora Cinellia Dermatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, ItalyView further author information
,
Gabriella Fabbrocinia Dermatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, ItalyView further author information
,
Aimilios Lallasb First Department of Dermatology, Aristotle University, Thessaloniki, GreeceORCID Iconhttps://orcid.org/0000-0002-7193-0964View further author information
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Massimiliano Scalvenzia Dermatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, ItalyView further author information
Pages 1585-1594 | Received 29 Aug 2020, Accepted 13 Oct 2020, Published online: 22 Oct 2020

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Eugenia Veronica Di Brizzi, Giuseppe Argenziano, Gabriella Brancaccio, Camila Scharf, Andrea Ronchi & Elvira Moscarella. (2023) The current clinical approach to difficult-to-treat basal cell carcinomas. Expert Review of Anticancer Therapy 23:1, pages 43-56.
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Kelly M Elleson, Danielle K DePalo & Jonathan S Zager. (2022) An update on local and systemic therapies for nonmelanoma skin cancer. Expert Review of Anticancer Therapy 22:5, pages 479-489.
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Harrison Zhu & Daniel J. Lewis. (2022) Topical hedgehog inhibitors for basal cell carcinoma: how far away are we?. Expert Opinion on Pharmacotherapy 23:6, pages 739-740.
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Alessia Villani, Gabriella Fabbrocini, Francesc Di Vico, Francesca Nastro & Massimiliano Scalvenzi. (2022) Resistance to hedgehog inhibitors in basal cell carcinoma: strategies to adopt. Expert Opinion on Drug Safety 21:4, pages 583-584.
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Harrison Zhu & Daniel J. Lewis. (2022) Genetic alterations conferring resistance to hedgehog inhibitors in basal cell carcinoma. Expert Opinion on Drug Safety 21:4, pages 581-582.
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Egle Ramelyte, Gaetana Restivo, Maria Mannino, Mitchell P Levesque & Reinhard Dummer. (2022) Advances in the drug management of basal cell carcinoma. Expert Opinion on Pharmacotherapy 23:5, pages 573-582.
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Alessia Villani, Gabriella Fabbrocini, Claudia Costa, Sonia Sofia Ocampo-Garza, Aimilios Lallas & Massimiliano Scalvenzi. (2021) Expert opinion on sonidegib efficacy, safety and tolerability. Expert Opinion on Drug Safety 20:8, pages 877-882.
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Articles from other publishers (15)

Ariel Berl, Ofir Shir-az, Ilai Genish, Hadas Biran, Din Mann, Amrita Singh, Julia Wise, Vladimir Kravtsov, Debora Kidron, Alexander Golberg, Edward Vitkin, Zohar Yakhini & Avshalom Shalom. (2023) Exploring multisite heterogeneity of human basal cell carcinoma proteome and transcriptome. PLOS ONE 18:11, pages e0293744.
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Alessia Villani, Massimiliano Scalvenzi, Giuseppe Micali, Francesco Lacarrubba, Luigi Fornaro, Fabrizio Martora & Luca Potestio. (2023) Management of Advanced Invasive Melanoma: New Strategies. Advances in Therapy 40:8, pages 3381-3394.
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Francesca COMITO, Ambrogio GAGLIANO, Francesca SPERANDI, Emi DIKA, Francesco SAVOIA & Barbara MELOTTI. (2023) Retreatment with sonidegib in a patient with multiple basal cell carcinomas and multiple comorbidities: a complex real-life scenario. Italian Journal of Dermatology and Venereology 158:2.
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Melania Parisi, Mariavittoria Verrillo, Maria Antonietta Luciano, Giuseppina Caiazzo, Maria Quaranta, Francesco Scognamiglio, Vincenzo Di Meo, Alessia Villani, Mariateresa Cantelli, Lucia Gallo, Giovanna G. Altobelli, Serena Poggi, Riccardo Spaccini & Gabriella Fabbrocini. (2023) Use of Natural Agents and Agrifood Wastes for the Treatment of Skin Photoaging. Plants 12:4, pages 840.
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Alessia Villani, Luca Potestio, Gabriella Fabbrocini, Francesca di Vico, Claudia Costa & Massimiliano Scalvenzi. (2022) Long‐term efficacy of telemedicine for patients with locally advanced basal cell carcinoma during COVID‐19 pandemic. Dermatologic Therapy 35:11.
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Wenzhen Ge, Chieh-I Chen, Ning Wu, Matthew G Fury, Emily Ruiz & Jessica J Jalbert. (2022) Hedgehog pathway inhibitor real-world treatment patterns in patients with basal cell carcinoma: a claims-based analysis. Future Oncology 18:23, pages 2561-2572.
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Alessia Villani, Gabriella Fabbrocini & Massimiliano Scalvenzi. (2022) Sonidegib‐induced muscle spasms in the treatment of basal cell carcinoma: Strategies to adopt. Dermatologic Therapy 35:7.
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Alessia Villani, Luca Potestio, Gabriella Fabbrocini, Giancarlo Troncone, Umberto Malapelle & Massimiliano Scalvenzi. (2022) The Treatment of Advanced Melanoma: Therapeutic Update. International Journal of Molecular Sciences 23:12, pages 6388.
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Alicia Ballester, Adriana Guijarro, Beatriz Bravo, Javier Hernández, Rodolfo Murillas, Marta I. Gallego & Sara Ballester. (2022) Hedgehog Signalling Modulates Immune Response and Protects against Experimental Autoimmune Encephalomyelitis. International Journal of Molecular Sciences 23:6, pages 3171.
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Filomena Russo, Linda Tognetti, Francesco Santi, Laura Lazzeri, Pietro Rubegni & Paolo Taddeucci. (2022) Long‐term efficacy of a Vismodegib regime including a 1‐week drug holiday every month in two patients with Gorlin Goltz syndrome. Dermatologic Therapy 35:3.
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Alessia Villani, Luca Potestio, Gabriella Fabbrocini & Massimiliano Scalvenzi. (2022) New Emerging Treatment Options for Advanced Basal Cell Carcinoma and Squamous Cell Carcinoma. Advances in Therapy 39:3, pages 1164-1178.
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Riyad N. H. Seervai, Woo Cheal Cho, Emily Y. Chu, Mario L. Marques‐Piubelli, Debora A. Ledesma, Kristen Richards, Meghan M. Heberton, Kelly C. Nelson, Priyadharsini Nagarajan, Carlos A. Torres‐Cabala, Victor G. Prieto & Jonathan L. Curry. (2021) Diverse landscape of dermatologic toxicities from small‐molecule inhibitor cancer therapy. Journal of Cutaneous Pathology 49:1, pages 61-81.
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John T. Lear, Reinhard Dummer & Alexander Guminski. (2021) Using drug scheduling to manage adverse events associated with hedgehog pathway inhibitors for basal cell carcinoma. Oncotarget 12:26, pages 2531-2540.
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Barbara Bellei, Silvia Caputo, Emilia Migliano, Gianluca Lopez, Valeria Marcaccini, Carlo Cota & Mauro Picardo. (2021) Simultaneous Targeting Tumor Cells and Cancer-Associated Fibroblasts with a Paclitaxel–Hyaluronan Bioconjugate: In Vitro Evaluation in Non-Melanoma Skin Cancer. Biomedicines 9:6, pages 597.
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Paweł Cisek, Dariusz Kieszko, Mateusz Bilski, Radomir Dębicki, Ewelina Grywalska, Rafał Hrynkiewicz, Dominika Bębnowska, Izabela Kordzińska-Cisek, Agnieszka Rolińska, Paulina Niedźwiedzka-Rystwej & Ludmiła Grzybowska-Szatkowska. (2021) Interstitial HDR Brachytherapy in the Treatment of Non-Melanocytic Skin Cancers around the Eye. Cancers 13:6, pages 1425.
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