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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 17, 2002 - Issue 6
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Research Article

Rho-kinase Inhibitors: Pharmacomodulations on the Lead Compound Y-32885

Cédric Logé Laboratoire de Chimie Thérapeutique, Faculté des Sciences Pharmaceutiques et Biologiques, BP 83, 59006 Lille Cedex, France
,
Valérie Wallez Laboratoire de Chimie Thérapeutique, Faculté des Sciences Pharmaceutiques et Biologiques, BP 83, 59006 Lille Cedex, France
,
Elizabeth Scalbert Institut de Recherches Internationales Servier, 6 place des Pléiades, 92415 Courbevoie Cedex, France
,
Christelle Cario-Tourmaniantz INSERM, Unité 533, Faculté des Sciences et Techniques de Nantes, 2 rue de la Houssinière, 44322 Nantes Cedex 3, France
,
Gervaise Loirand INSERM, Unité 533, Faculté des Sciences et Techniques de Nantes, 2 rue de la Houssinière, 44322 Nantes Cedex 3, France
,
Pierre Pacaud INSERM, Unité 533, Faculté des Sciences et Techniques de Nantes, 2 rue de la Houssinière, 44322 Nantes Cedex 3, France
&
Daniel Lesieur Laboratoire de Chimie Thérapeutique, Faculté des Sciences Pharmaceutiques et Biologiques, BP 83, 59006 Lille Cedex, France
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Pages 381-390 | Published online: 30 Sep 2008

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Fabrizio Carta, Claudiu T Supuran & Andrea Scozzafava. (2012) Novel therapies for glaucoma: a patent review 2007 – 2011. Expert Opinion on Therapeutic Patents 22:1, pages 79-88.
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Articles from other publishers (12)

Kinga Czarnota-Łydka, Katarzyna Kucwaj-Brysz, Patryk Pyka, Wawrzyniec Haberek, Sabina Podlewska & Jadwiga Handzlik. (2022) Multitargeting the Action of 5-HT6 Serotonin Receptor Ligands by Additional Modulation of Kinases in the Search for a New Therapy for Alzheimer’s Disease: Can It Work from a Molecular Point of View?. International Journal of Molecular Sciences 23:15, pages 8768.
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Vasudha Abbhi & Poonam Piplani. (2020) Rho-kinase (ROCK) Inhibitors - A Neuroprotective Therapeutic Paradigm with a Focus on Ocular Utility. Current Medicinal Chemistry 27:14, pages 2222-2256.
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Alain-Pierre Petit, Christel Garcia-Petit, Juan A. Bueren-Calabuig, Laurent M. Vuillard, Gilles Ferry & Jean A. Boutin. (2018) A structural study of the complex between neuroepithelial cell transforming gene 1 (Net1) and RhoA reveals a potential anticancer drug hot spot. Journal of Biological Chemistry 293:23, pages 9064-9077.
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Chuipu Cai, Qihui Wu, Yunxia Luo, Huili Ma, Jiangang Shen, Yongbin Zhang, Lei Yang, Yunbo Chen, Zehuai Wen & Qi Wang. (2017) In silico prediction of ROCK II inhibitors by different classification approaches. Molecular Diversity 21:4, pages 791-807.
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Aneta Gandalovičová, Daniel Rosel, Michael Fernandes, Pavel Veselý, Petr Heneberg, Vladimír Čermák, Luboš Petruželka, Sunil Kumar, Victoria Sanz-Moreno & Jan Brábek. (2017) Migrastatics—Anti-metastatic and Anti-invasion Drugs: Promises and Challenges. Trends in Cancer 3:6, pages 391-406.
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Surmil Shah & Jignasa Savjani. (2016) A review on ROCK-II inhibitors: From molecular modelling to synthesis. Bioorganic & Medicinal Chemistry Letters 26:10, pages 2383-2391.
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Yangbo Feng, Philip V. LoGrasso, Olivier Defert & Rongshi Li. (2015) Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential. Journal of Medicinal Chemistry 59:6, pages 2269-2300.
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Muriel Bonnet, Jack U. Flanagan, Denise A. Chan, Amato J. Giaccia & Michael P. Hay. (2014) Identifying novel targets in renal cell carcinoma: Design and synthesis of affinity chromatography reagents. Bioorganic & Medicinal Chemistry 22:2, pages 711-720.
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Jose L. Orgaz & Victoria Sanz-Moreno. (2013) Emerging molecular targets in melanoma invasion and metastasis. Pigment Cell & Melanoma Research 26:1, pages 39-57.
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Akitoshi Tsuno, Kaei Nasu, Yukie Kawano, Akitoshi Yuge, Haili Li, Wakana Abe & Hisashi Narahara. (2011) Fasudil Inhibits the Proliferation and Contractility and Induces Cell Cycle Arrest and Apoptosis of Human Endometriotic Stromal Cells: A Promising Agent for the Treatment of Endometriosis. The Journal of Clinical Endocrinology & Metabolism 96:12, pages E1944-E1952.
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Ming Dong, Bryan P. Yan, James K. Liao, Yat-Yin Lam, Gabriel W.K. Yip & Cheuk-Man Yu. (2010) Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases. Drug Discovery Today 15:15-16, pages 622-629.
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B Wojciak-Stothard. (2008) New drug targets for pulmonary hypertension: Rho GTPases in pulmonary vascular remodelling. Postgraduate Medical Journal 84:993, pages 348-353.
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