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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 17, 2002 - Issue 6
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Research Article

Design, Synthesis and In Vitro Evaluation of Novel Derivatives as Serotonin N -Acetyltransferase Inhibitors

N. Beaurain Laboratoire de Chimie Thérapeutique, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Lille 2, BP 83, 59006 Lille Cédex, France
,
C. Mésangeau Laboratoire de Chimie Thérapeutique, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Lille 2, BP 83, 59006 Lille Cédex, France
,
P. Chavatte Laboratoire de Chimie Thérapeutique, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Lille 2, BP 83, 59006 Lille Cédex, France
,
G. Ferry Institut de Recherches Internationales Servier, 125 chemin de Ronde, 78290 Croissy, France
,
V. Audinot Institut de Recherches Internationales Servier, 125 chemin de Ronde, 78290 Croissy, France
,
J.A. Boutin Institut de Recherches Internationales Servier, 125 chemin de Ronde, 78290 Croissy, France
,
P. Delagrange Institut de Recherches Internationales Servier, 6 place des pléiades, 92415 Courbevoie Cédex, France
,
C. Bennejean Institut de Recherches Internationales Servier, 6 place des pléiades, 92415 Courbevoie Cédex, France
&
S. Yous Laboratoire de Chimie Thérapeutique, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Lille 2, BP 83, 59006 Lille Cédex, France
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Pages 409-414 | Published online: 30 Sep 2008

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Ji-Long Zhang, Qing-Chuan Zheng, Zheng-Qiang Li & Hong-Xing Zhang. (2014) Theoretical evaluation and improvement on the potency of the rhodanine-based inhibitors for human serotonin N-acetyltransferase. Molecular Simulation 40:15, pages 1201-1208.
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C. Mesangeau, S. Yous, P. Chavatte, G. Ferry, V. Audinot, J.A. Boutin, P. Delagrange, C. Bennejean, P. Renard & D. Lesieur. (2003) Design, Synthesis and In Vitro Evaluation of Novel Benzo[b]thiophene Derivatives as Serotonin N-acetyltransferase (AANAT) Inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 18:2, pages 119-125.
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Articles from other publishers (11)

Desheng Zhang, Jian Zhang, Ting Liu, Shang Wu, Zengxue Wu, Sikai Wu, Runjiang Song & Baoan Song. (2022) Discovery of Pyrido[1,2- a ]pyrimidine Mesoionic Compounds Containing Benzo[ b ]thiophene Moiety as Potential Pesticide Candidates . Journal of Agricultural and Food Chemistry 70:28, pages 8598-8608.
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Jean A. Boutin. 2018. Melatonin - Molecular Biology, Clinical and Pharmaceutical Approaches. Melatonin - Molecular Biology, Clinical and Pharmaceutical Approaches.
Christophe Mésangeau, Mikaël Fraise, Philippe Delagrange, Daniel Henri Caignard, Jean Albert Boutin, Pascal Berthelot & Saïd Yous. (2011) Preparation and pharmacological evaluation of a novel series of 2-(phenylthio)benzo[b]thiophenes as selective MT2 receptor ligands. European Journal of Medicinal Chemistry 46:5, pages 1835-1840.
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Alban Lepailleur, Stéphane Lemaître, Xiao Feng, Jana Sopkova-de Oliveira Santos, Philippe Delagrange, Jean Boutin, Pierre Renard, Ronan Bureau & Sylvain Rault. (2010) Receptor- and Ligand-Based Study on Novel 2,2′-Bithienyl Derivatives as Non-Peptidic AANAT Inhibitors. Journal of Chemical Information and Modeling 50:3, pages 446-460.
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Lawrence M. Szewczuk, S. Adrian Saldanha, Surajit Ganguly, Erin M. Bowers, Margarita Javoroncov, Balasubramanyam Karanam, Jeffrey C. Culhane, Marc A. Holbert, David C. Klein, Ruben Abagyan & Philip A. Cole. (2007) De Novo Discovery of Serotonin N -Acetyltransferase Inhibitors . Journal of Medicinal Chemistry 50:22, pages 5330-5338.
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Yousang Hwang, Surajit Ganguly, Anthony K. Ho, David C. Klein & Philip A. Cole. (2007) Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug. Bioorganic & Medicinal Chemistry 15:5, pages 2147-2155.
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Jean A. Boutin, Valérie Audinot, Gilles Ferry & Philippe Delagrange. (2005) Molecular tools to study melatonin pathways and actions. Trends in Pharmacological Sciences 26:8, pages 412-419.
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Christophe Mésangeau, Saïd Yous, Basile Pérès, Daniel Lesieur & Thierry Besson. (2005) Pictet–Spengler heterocyclizations via microwave-assisted degradation of DMSO. Tetrahedron Letters 46:14, pages 2465-2468.
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Gilles Ferry, Caroline Ubeaud, Claire Dauly, Julien Mozo, Sophie Guillard, Sylvie Berger, Sandrine Jimenez, Catherine Scoul, Gregory Leclerc, Saïd Yous, Philippe Delagrange & Jean A. Boutin. (2004) Purification of the recombinant human serotonin N-acetyltransferase (EC 2.3.1.87): further characterization of and comparison with AANAT from other species. Protein Expression and Purification 38:1, pages 84-98.
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Gilles Ferry, Caroline Ubeaud, Julien Mozo, Christophe Péan, Philippe Hennig, Marianne Rodriguez, Catherine Scoul, Anne Bonnaud, Olivier Nosjean, Jean‐Pierre Galizzi, Philippe Delagrange, Pierre Renard, Jean‐Paul Volland, Said Yous, Daniel Lesieur & Jean A. Boutin. (2003) New substrate analogues of human serotonin N ‐acetyltransferase produce in situ specific and potent inhibitors . European Journal of Biochemistry 271:2, pages 418-428.
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Weiping Zheng & Philip A Cole. (2003) Novel bisubstrate analog inhibitors of serotonin N-acetyltransferase: the importance of being neutral. Bioorganic Chemistry 31:5, pages 398-411.
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