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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 17, 2002 - Issue 2
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Research Article

Some Coumarins and Triphenylethene Derivatives as Inhibitors of Human Testes Microsomal 17β-hydroxysteroid Dehydrogenase (17β-HSD Type 3): Further Studies with Tamoxifen on the Rat Testes Microsomal Enzyme

R. Le Lain Welsh School of Pharmacy, Cardiff University, Cathays Park, Cardiff, CF10 3XF, UK
,
K.J. Barrell Welsh School of Pharmacy, Cardiff University, Cathays Park, Cardiff, CF10 3XF, UK
,
G.S. Saeed Welsh School of Pharmacy, Cardiff University, Cathays Park, Cardiff, CF10 3XF, UK
,
P.J. Nicholls Welsh School of Pharmacy, Cardiff University, Cathays Park, Cardiff, CF10 3XF, UK
,
C. Simons Welsh School of Pharmacy, Cardiff University, Cathays Park, Cardiff, CF10 3XF, UK
,
A. Kirby Welsh School of Pharmacy, Cardiff University, Cathays Park, Cardiff, CF10 3XF, UK
&
H.J. Smith Welsh School of Pharmacy, Cardiff University, Cathays Park, Cardiff, CF10 3XF, UK
 show all
Pages 93-100 | Published online: 30 Sep 2008

Citations (17)

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Christos Kontogiorgis, Anastasia Detsi & Dimitra Hadjipavlou-Litina. (2012) Coumarin-based drugs: a patent review (2008 – present). Expert Opinion on Therapeutic Patents 22:4, pages 437-454.
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Matej Živec, Matej Sova, Mojca Brunskole, Roman Lenaršič, Tea Lanišnik Rižner & Stanislav Gobec. (2007) New inhibitors of fungal 17β-hydroxysteroid dehydrogenase based on the [1,5]-benzodiazepine scaffold. Journal of Enzyme Inhibition and Medicinal Chemistry 22:1, pages 29-36.
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Articles from other publishers (15)

Gowri Gopa Kumar, Eswar Kumar Kilari, Giribabu Nelli & Naguib Bin Salleh. (2023) Oral administration of Turnera diffusa willd. ex Schult. extract ameliorates steroidogenesis and spermatogenesis impairment in the testes of rats with type-2 diabetes mellitus. Journal of Ethnopharmacology 314, pages 116638.
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Ran An, Zhuang Hou, Jian-Teng Li, Hao-Nan Yu, Yan-Hua Mou & Chun Guo. (2018) Design, Synthesis and Biological Evaluation of Novel 4-Substituted Coumarin Derivatives as Antitumor Agents. Molecules 23:9, pages 2281.
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Saeed Emami & Sakineh Dadashpour. (2015) Current developments of coumarin-based anti-cancer agents in medicinal chemistry. European Journal of Medicinal Chemistry 102, pages 611-630.
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Joanna M Day, Paul A Foster, Helena J Tutill, Fabien Schmidlin, Christopher M Sharland, Jonathan D Hargrave, Nigel Vicker, Barry V L Potter, Michael J Reed & Atul Purohit. (2013) STX2171, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, is efficacious in vivo in a novel hormone-dependent prostate cancer model. Endocrine-Related Cancer 20:1, pages 53-64.
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Lyubomir G. Nashev, Daniela Schuster, Christian Laggner, Seloni Sodha, Thierry Langer, Gerhard Wolber & Alex Odermatt. (2010) The UV-filter benzophenone-1 inhibits 17β-hydroxysteroid dehydrogenase type 3: Virtual screening as a strategy to identify potential endocrine disrupting chemicals. Biochemical Pharmacology 79:8, pages 1189-1199.
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Koichiro Harada, Hideki Kubo, Yoshitaka Tomigahara, Kazuhiko Nishioka, Junya Takahashi, Mio Momose, Shinichi Inoue & Atsuyuki Kojima. (2010) Coumarins as novel 17β-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer. Bioorganic & Medicinal Chemistry Letters 20:1, pages 272-275.
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Joanna M. Day, Helena J. Tutill, Paul A. Foster, Helen V. Bailey, Wesley B. Heaton, Christopher M. Sharland, Nigel Vicker, Barry V.L. Potter, Atul Purohit & Michael J. Reed. (2009) Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17β-hydroxysteroid dehydrogenase Type 3. Molecular and Cellular Endocrinology 301:1-2, pages 251-258.
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Matej Sova, Andrej Perdih, Miha Kotnik, Katja Kristan, Tea Lanišnik Rižner, Tom Solmajer & Stanislav Gobec. (2006) Flavonoids and cinnamic acid esters as inhibitors of fungal 17β-hydroxysteroid dehydrogenase: A synthesis, QSAR and modelling study. Bioorganic & Medicinal Chemistry 14:22, pages 7404-7418.
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Petra Brožič, Tina Šmuc, Stanislav Gobec & Tea Lanišnik Rižner. (2006) Phytoestrogens as inhibitors of the human progesterone metabolizing enzyme AKR1C1. Molecular and Cellular Endocrinology 259:1-2, pages 30-42.
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Petra Lukacik, Kathryn L. Kavanagh & Udo Oppermann. (2006) Structure and function of human 17β-hydroxysteroid dehydrogenases. Molecular and Cellular Endocrinology 248:1-2, pages 61-71.
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Katja Kristan, Katja Krajnc, Janez Konc, Stanislav Gobec, Jure Stojan & Tea Lanišnik Rižner. (2005) Phytoestrogens as inhibitors of fungal 17β-hydroxysteroid dehydrogenase. Steroids 70:10, pages 694-703.
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Béatrice Tchédam Ngatcha, Van Luu-The, Fernand Labrie & Donald Poirier. (2005) Androsterone 3α-Ether-3β-Substituted and Androsterone 3β-Substituted Derivatives as Inhibitors of Type 3 17β-Hydroxysteroid Dehydrogenase:  Chemical Synthesis and Structure−Activity Relationship. Journal of Medicinal Chemistry 48:16, pages 5257-5268.
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Katja Kristan, Katja Krajnc, Janez Konc, Stanislav Gobec, Jure Stojan & Tea Lanišnik Rižner. (2005) Phytoestrogens as inhibitors of fungal 17β-hydroxysteroid dehydrogenase. Steroids 70:9, pages 626-635.
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Stanislav Gobec, Matej Sova, Katja Kristan & Tea Lanišnik Rižner. (2004) Cinnamic acid esters as potent inhibitors of fungal 17β-hydroxysteroid dehydrogenase––a model enzyme of the short-chain dehydrogenase/reductase superfamily. Bioorganic & Medicinal Chemistry Letters 14:15, pages 3933-3936.
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Nicodéme Paul, Esther Kellenberger, Guillaume Bret, Pascal Müller & Didier Rognan. (2004) Recovering the true targets of specific ligands by virtual screening of the protein data bank. Proteins: Structure, Function, and Bioinformatics 54:4, pages 671-680.
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