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Research Article

Pyrrolylbenzothiazole Derivatives as Aldose Reductase Inhibitors

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Pages 131-135 | Published online: 30 Sep 2008

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Abdelrahman Hamdi, Muhammad Yaseen, Wafaa A. Ewes, Mashooq Ahmad Bhat, Noha I. Ziedan, Hamed W. El-Shafey, Ahmed A. B. Mohamed, Mohamed R. Elnagar, Abdullah Haikal, Dina I. A. Othman, Abdullah A. Elgazar, Ahmed H. A. Abusabaa, Kamal S. Abdelrahman, Osama M. Soltan & Mostafa M. Elbadawi. (2023) Development of new thiazolidine-2,4-dione hybrids as aldose reductase inhibitors endowed with antihyperglycaemic activity: design, synthesis, biological investigations, and in silico insights. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Articles from other publishers (15)

Priyanka Kashyap, Sangeeta Verma, Pankaj Gupta, Rakesh Narang, Sukhbir Lal & Manish Devgun. (2023) Recent insights into antibacterial potential of benzothiazole derivatives. Medicinal Chemistry Research 32:8, pages 1543-1573.
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Mahavir Singh, Aniruddh Kapoor & Aruni Bhatnagar. (2021) Physiological and Pathological Roles of Aldose Reductase. Metabolites 11:10, pages 655.
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Muhammad Tariq Shehzad, Aqeel Imran, Abdul Hameed, Mariya al Rashida, Marium Bibi, Maliha Uroos, Asnuzilawati Asari, Shafia Iftikhar, Habsah Mohamad, Muhammad Nawaz Tahir, Zahid Shafiq & Jamshed Iqbal. (2021) Exploring synthetic and therapeutic prospects of new thiazoline derivatives as aldose reductase (ALR2) inhibitors. RSC Advances 11:28, pages 17259-17282.
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Antonios Kousaxidis, Anthi Petrou, Vasiliki Lavrentaki, Maria Fesatidou, Ioannis Nicolaou & Athina Geronikaki. (2020) Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus. European Journal of Medicinal Chemistry 207, pages 112742.
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Neeraj Bainsal, Jitender Singh & Aman Thakur. (2020) EMERGENCE OF BENZOTHIAZOLE AND ITS DERIVATIVES AS A POTENTIAL ANTIDIABETIC PROBE. INDIAN DRUGS 57:07, pages 7-18.
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Appian Subramoniam. 2016. Anti-Diabetes Mellitus Plants. Anti-Diabetes Mellitus Plants 301 380 .
Marios Chrysanthakopoulos, Ioannis Nicolaou, Vassilis Demopoulos & Anna Tsantili-Kakoulidou. (2012) The efficiency of RP-TLC for lipophilicity assessment. A comparative study on a series of pyrrolyl-acetic acid derivatives, inhibitors of aldose reductase. Journal of Planar Chromatography – Modern TLC 25:4, pages 349-354.
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Marios Chrysanthakopoulos, Ioannis Nicolaou, Vassilis J. Demopoulos & Anna Tsantili-Kakoulidou. (2010) HPLC-based lipophilicity of pyrrolyl-acetic acid ARIs: Relationships with biological activity. Journal of Chromatography B 878:1, pages 61-67.
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Marios Chrysanthakopoulos, Antigoni Koletsou, Ioannis Nicolaou, Vassilis J. Demopoulos & Anna Tsantili-Kakoulidou. (2009) Lipophilicity Studies on Pyrrolyl-Acetic Acid Derivatives. Experimental Versus Predicted log P Values in Relationship with Aldose Reductase Inhibitory Activity . QSAR & Combinatorial Science 28:5, pages 551-560.
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Vassilis J. Demopoulos, Ioannis Nicolaou, Polyxeni Alexiou, Chariklia Zika, Katja Sturm & Albin Kristl. 2007. Brilliant Light in Life and Material Sciences. Brilliant Light in Life and Material Sciences 241 250 .
Katja Šturm, Lea Levstik, Vassilis J. Demopoulos & Albin Kristl. (2006) Permeability characteristics of novel aldose reductase inhibitors using rat jejunum in vitro. European Journal of Pharmaceutical Sciences 28:1-2, pages 128-133.
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Catherine Koukoulitsa, Chariklia Zika, George D. Geromichalos, Vassilis J. Demopoulos & Helen Skaltsa. (2006) Evaluation of aldose reductase inhibition and docking studies of some secondary metabolites, isolated from Origanum vulgare L. ssp. hirtum. Bioorganic & Medicinal Chemistry 14:5, pages 1653-1659.
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Ioannis Nicolaou, Chariklia Zika & Vassilis J. Demopoulos. (2004) [1-(3,5-Difluoro-4-hydroxyphenyl)-1 H -pyrrol-3-yl]phenylmethanone as a Bioisostere of a Carboxylic Acid Aldose Reductase Inhibitor . Journal of Medicinal Chemistry 47:10, pages 2706-2709.
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Vassilis John Demopoulos, Ioannis Nicolaou & Chariklia Zika. (2003) A Facile Preparation of 1-(6-Hydroxyindol-1-yl)-2,2-dimethylpropan-1-one. CHEMICAL & PHARMACEUTICAL BULLETIN 51:1, pages 98-99.
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Ioannis Nicolaou & Vassilis J. Demopoulos. (2002) Substituted Pyrrol-1-ylacetic Acids That Combine Aldose Reductase Enzyme Inhibitory Activity and Ability To Prevent the Nonenzymatic Irreversible Modification of Proteins from Monosaccharides. Journal of Medicinal Chemistry 46:3, pages 417-426.
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