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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 18, 2003 - Issue 3
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Research Article

Inhibition of Fatty Acid Amidohydrolase, the Enzyme Responsible for the Metabolism of the Endocannabinoid Anandamide, by Analogues of Arachidonoyl-serotonin

Christopher J. Fowler Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-901 87 Umeå, Sweden
,
Gunnar Tiger Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-901 87 Umeå, Sweden
,
María L. López-Rodríguez Departamento de Química Orgánica I, Facultad de Ciencias Químicas Univesidad Complutense, E-28040 Madrid, Spain
,
Alma Viso Departamento de Química Orgánica I, Facultad de Ciencias Químicas Univesidad Complutense, E-28040 Madrid, Spain
,
Silvia Ortega-Gutiérrez Departamento de Química Orgánica I, Facultad de Ciencias Químicas Univesidad Complutense, E-28040 Madrid, Spain
&
José A. Ramos Departamento de Bioquímica y Biología Molecular III, Facultad de Medicina, Universidad Complutense, E-28040 Madrid, Spain
Pages 225-231 | Published online: 19 Jun 2013

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A. L. M. Brand, F. A. Lima, N. A. B. Tinoco, J. C. Mota, I. G. S. Moreira, F. J. M. Novaes, R. Garrett, T. B. S. Giorno, P. D. Fernandes & C. M. Rezende. (2023) ΒN-Alkanoyl-5-Hydroxytryptamines (Cn-5HTs) in Coffee: A Review. Food Reviews International 39:7, pages 4761-4780.
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Articles from other publishers (17)

Lauren N. Carnevale & Aditi Das. 2019. The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases. The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases 219 232 .
Alessandro Deplano, Carmine Marco Morgillo, Monica Demurtas, Emmelie Björklund, Mariateresa Cipriano, Mona Svensson, Sanaz Hashemian, Giovanni Smaldone, Emilia Pedone, F. Javier Luque, Maria G. Cabiddu, Ettore Novellino, Christopher J. Fowler, Bruno Catalanotti & Valentina Onnis. (2017) Novel propanamides as fatty acid amide hydrolase inhibitors. European Journal of Medicinal Chemistry 136, pages 523-542.
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Samira Gholami, Abdol-Khalegh Bordbar & Nadia Akvan. (2016) Spectroscopic and dynamic properties of arachidonoyl serotonin- β-lactoglobulin complex: A molecular modeling and chemometric study. Journal of Photochemistry and Photobiology B: Biology 162, pages 519-528.
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Natalia Malek & Katarzyna Starowicz. (2016) Dual-Acting Compounds Targeting Endocannabinoid and Endovanilloid Systems—A Novel Treatment Option for Chronic Pain Management. Frontiers in Pharmacology 7.
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Luciano De Petrocellis & Vincenzo Di Marzo. 2015. The Endocannabinoidome. The Endocannabinoidome 67 84 .
Giorgio Ortar, Luciano De Petrocellis, Aniello Schiano Moriello, Marco Allarà, Enrico Morera, Marianna Nalli & Vincenzo Di Marzo. (2013) Tetrahydro-β-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels. Bioorganic & Medicinal Chemistry Letters 23:1, pages 138-142.
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Andrew J Gilmore, Marika Heblinski, Aaron Reynolds, Michael Kassiou & Mark Connor. (2012) Inhibition of human recombinant T-type calcium channels by N -arachidonoyl 5-HT . British Journal of Pharmacology 167:5, pages 1076-1088.
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Kitty C.M. Verhoeckx, Trudy Voortman, Michiel G.J. Balvers, Henk F.J. Hendriks, Heleen M.Wortelboer & Renger F. Witkamp. (2011) Presence, formation and putative biological activities of N-acyl serotonins, a novel class of fatty-acid derived mediators, in the intestinal tract. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1811:10, pages 578-586.
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Barbara Costa, Isabella Bettoni, Stefania Petrosino, Francesca Comelli, Gabriella Giagnoni & Vincenzo Di Marzo. (2010) The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice. Pharmacological Research 61:6, pages 537-546.
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CJ Fowler, PS Naidu, A Lichtman & V Onnis. (2009) The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1. British Journal of Pharmacology 156:3, pages 412-419.
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Vincenzo Micale, Luigia Cristino, Alessandra Tamburella, Stefania Petrosino, Gian Marco Leggio, Filippo Drago & Vincenzo Di Marzo. (2008) Anxiolytic Effects in Mice of a Dual Blocker of Fatty Acid Amide Hydrolase and Transient Receptor Potential Vanilloid Type-1 Channels. Neuropsychopharmacology 34:3, pages 593-606.
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Vincenzo Di Marzo. (2008) Targeting the endocannabinoid system: to enhance or reduce?. Nature Reviews Drug Discovery 7:5, pages 438-455.
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Giorgio OrtarMaria Grazia CascioLuciano De PetrocellisEnrico MoreraFrancesca RossiAniello Schiano-MorielloMarianna NalliVito de NovellisDavid F. WoodwardSabatino MaioneVincenzo Di Marzo. (2007) New N -Arachidonoylserotonin Analogues with Potential “Dual” Mechanism of Action against Pain . Journal of Medicinal Chemistry 50:26, pages 6554-6569.
Crossref
S Maione, L De Petrocellis, V de Novellis, A Schiano Moriello, S Petrosino, E Palazzo, F Sca Rossi, D F Woodward & V Di Marzo. (2007) Analgesic actions of N -arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors . British Journal of Pharmacology 150:6, pages 766-781.
Crossref
Vincenzo Di Marzo & Alessia Ligresti. 2005. Endocannabinoids. Endocannabinoids.
V. Di Marzo, T. Bisogno & L. De Petrocellis. 2005. Cannabinoids. Cannabinoids 147 185 .
Lidia Ruiz-Llorente, Silvia Ortega-Gutiérrez, Alma Viso, María G Sánchez, Ana M Sánchez, Carlos Fernández, José A Ramos, Cecilia Hillard, Miguel A Lasunción, María L López-Rodríguez & Inés Díaz-Laviada. (2004) Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study. British Journal of Pharmacology 141:3, pages 457-467.
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