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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 18, 2003 - Issue 3
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Research Article

Protease Inhibitors: Synthesis of Bacterial Collagenase and Matrix Metalloproteinase Inhibitors Incorporating Succinyl Hydroxamate and Iminodiacetic Acid Hydroxamate Moieties

M. Amélia Santos Centro de Química Estrutural, Complexo I Instituto Superior Técnico 1049-001 Lisboa Portugal
,
Sérgio Marques Centro de Química Estrutural, Complexo I Instituto Superior Técnico 1049-001 Lisboa Portugal
,
Marco Gil Centro de Química Estrutural, Complexo I Instituto Superior Técnico 1049-001 Lisboa Portugal
,
Matteo Tegoni Dipartimento di Chimica Generale ed Inorganica, Chimica Analitica, Chimica Fisica Università di Parma 43100 Parma Italy
,
Andrea Scozzafava Università degli Studi di Firenze Laboratorio di Chimica Inorganica e Bioinorganica, Via della Lastruccia 3 Rm 188 Polo Scientifico 50019 Sesto Fiorentino (Firenze Italy
&
Claudiu T. Supuran Università degli Studi di Firenze Laboratorio di Chimica Inorganica e Bioinorganica, Via della Lastruccia 3 Rm 188 Polo Scientifico 50019 Sesto Fiorentino (Firenze Italy
Pages 233-242 | Published online: 30 Sep 2008

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Claudiu T. Supuran. (2017) Advances in structure-based drug discovery of carbonic anhydrase inhibitors. Expert Opinion on Drug Discovery 12:1, pages 61-88.
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Claudiu T. Supuran. (2016) How many carbonic anhydrase inhibition mechanisms exist?. Journal of Enzyme Inhibition and Medicinal Chemistry 31:3, pages 345-360.
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Articles from other publishers (14)

Clemente Capasso & Claudiu T. Supuran. 2024. Metalloenzymes. Metalloenzymes 185 195 .
Sijin Wu, Xuewei Zhou, Zhicheng Jin & Haiming Cheng. (2023) Collagenases and their inhibitors: a review. Collagen and Leather 5:1.
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Kaijun Gou, Xianmou Guo, Yuxin Wang, Yumei Wang, Zhentao Sang, Shuangshuang Ma, Yingyu Guo, Linlin Xie, Sanming Li & Heran Li. (2022) Chiral microenvironment-responsive mesoporous silica nanoparticles for delivering indometacin with chiral recognition function. Materials & Design 214, pages 110359.
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Katrin Voos, Esther Schönauer, Alaa Alhayek, Jörg Haupenthal, Anastasia Andreas, Rolf Müller, Rolf W. Hartmann, Hans Brandstetter, Anna K. H. Hirsch & Christian Ducho. (2021) Phosphonate as a Stable Zinc‐Binding Group for “Pathoblocker” Inhibitors of Clostridial Collagenase H (ColH). ChemMedChem 16:8, pages 1257-1267.
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Elisa Nuti, Doretta Cuffaro, Elisa Bernardini, Caterina Camodeca, Laura Panelli, Sílvia Chaves, Lidia Ciccone, Livia Tepshi, Laura Vera, Elisabetta Orlandini, Susanna Nencetti, Enrico A. Stura, M. Amélia Santos, Vincent Dive & Armando Rossello. (2018) Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies. Journal of Medicinal Chemistry 61:10, pages 4421-4435.
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Esther Schönauer, Andreas M. Kany, Jörg Haupenthal, Kristina Hüsecken, Isabel J. Hoppe, Katrin Voos, Samir Yahiaoui, Brigitta Elsässer, Christian Ducho, Hans Brandstetter & Rolf W. Hartmann. (2017) Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases. Journal of the American Chemical Society 139:36, pages 12696-12703.
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Yusralina Yusof, Daniel T.C. Tan, Omid Khalili Arjomandi, Gerhard Schenk & Ross P. McGeary. (2016) Captopril analogues as metallo-β-lactamase inhibitors. Bioorganic & Medicinal Chemistry Letters 26:6, pages 1589-1593.
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Esther Schönauer & Hans Brandstetter. 2017. Zinc Enzyme Inhibitors. Zinc Enzyme Inhibitors 69 94 .
Alane Beatriz Vermelho, Eliane Ferreira Noronha, Edivaldo Ximenes Ferreira Filho, Maria Antonieta Ferrara & Elba Pinto S. Bon. 2013. The Prokaryotes. The Prokaryotes 213 240 .
Tudor Petreus, Iulian Antoniac, Paul Sirbu & Carmen Elena Cotrutz. 2013. Biologically Responsive Biomaterials for Tissue Engineering. Biologically Responsive Biomaterials for Tissue Engineering 17 41 .
Jiahua Jiang, Anita Thyagarajan-Sahu, Viktor Krchňák, Andrej Jedinak, George E. Sandusky & Daniel Sliva. (2012) NAHA, a Novel Hydroxamic Acid-Derivative, Inhibits Growth and Angiogenesis of Breast Cancer In Vitro and In Vivo. PLoS ONE 7:3, pages e34283.
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Claudiu T. Supuran. 2009. Drug Design of Zinc‐Enzyme Inhibitors. Drug Design of Zinc‐Enzyme Inhibitors 721 729 .
M. Amelia Santos, Sergio Marques, Daniela Vullo, Alessio Innocenti, Andrea Scozzafava & Claudiu T. Supuran. (2007) Carbonic anhydrase inhibitors: Inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties. Bioorganic & Medicinal Chemistry Letters 17:6, pages 1538-1543.
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Claudia Temperini, Alessio Innocenti, Andrea Scozzafava & Claudiu T. Supuran. (2006) N-Hydroxyurea—A versatile zinc binding function in the design of metalloenzyme inhibitors. Bioorganic & Medicinal Chemistry Letters 16:16, pages 4316-4320.
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