Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 18, 2003 - Issue 4
Submit an article Journal homepage
185
Views
13
CrossRef citations to date
0
Altmetric
Research Article

3,5-Bis(Phenylmethylene)-1-(N-arylmaleamoyl)-4-piperidones: A Novel Group of Cytotoxic Agents

J.R. DIMMOCK College of Pharmacy and Nutrition, University of Saskatchewan, S7N 5C9, Saskatoon, Saskatchewan, CanadaCorrespondence[email protected]
,
A. JHA College of Pharmacy and Nutrition, University of Saskatchewan, S7N 5C9, Saskatoon, Saskatchewan, Canada
,
G.A. ZELLO College of Pharmacy and Nutrition, University of Saskatchewan, S7N 5C9, Saskatoon, Saskatchewan, Canada
,
R.K. SHARMA Department of Pathology, College of Medicine and Cancer Research Unit, Saskatoon Cancer Centre, S7N 4H4, Saskatoon, Saskatchewan, Canada
,
A. SHRIVASTAV Department of Pathology, College of Medicine and Cancer Research Unit, Saskatoon Cancer Centre, S7N 4H4, Saskatoon, Saskatchewan, Canada
,
P. SELVAKUMAR Department of Pathology, College of Medicine and Cancer Research Unit, Saskatoon Cancer Centre, S7N 4H4, Saskatoon, Saskatchewan, Canada
,
T.M. ALLEN Department of Pharmacology, University of Alberta, T6G 2H7, Edmonton, Alberta, Canada
,
C.L. SANTOS Department of Pharmacology, University of Alberta, T6G 2H7, Edmonton, Alberta, Canada
,
J. BALZARINI Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000, Leuven, Belgium
,
E. DE CLERCQ Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000, Leuven, Belgium
,
E.K. MANAVATHU Department of Medicine, Wayne State University, 48201-1098, Detroit, Michigan, USA
&
J.P. STABLES National Institute of Neurological Disorders and Stroke, National Institutes of Health, 20892-9020, Bethesda, Maryland, USA
 show all
Pages 325-332 | Received 26 Feb 2003, Accepted 31 Mar 2003, Published online: 03 Oct 2008

Citations (13)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Umashankar Das, Ponniah Selvakumar, Rajendra K. Sharma, Thomas A. Haas & Jonathan R. Dimmock. (2007) N–Acyl–3,5–bis(arylidene)-4-piperidones and related compounds which stimulate fyn kinase. Journal of Enzyme Inhibition and Medicinal Chemistry 22:4, pages 451-455.
Read now

Articles from other publishers (12)

Mehdi Ghandi, Marziyeh Eshaghi Kenari & Alireza Abbasi. (2019) Synthesis of novel spirofused spiropyrrolidine 1,3-indanedione derivatives via 1,3-dipolar cycloaddition reactions. Journal of the Iranian Chemical Society 17:3, pages 567-576.
Crossref
Amitabh Jha, Katherine M. Duffield, Matthew R. Ness, Sujatha Ravoori, Gabrielle Andrews, Khushwant S. Bhullar, H.P. Vasantha Rupasinghe & Jan Balzarini. (2015) Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors. Bioorganic & Medicinal Chemistry 23:19, pages 6404-6417.
Crossref
Elizabeth Potter, Mamta Jha, Khushwant S. Bhullar, H.P. Vasantha Rupasinghe, Jan Balzarini & Amitabh Jha. (2015) Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors. Bioorganic & Medicinal Chemistry 23:3, pages 411-421.
Crossref
Nawal K. Paul, Mamta Jha, Khushwant S. Bhullar, H.P. Vasantha Rupasinghe, Jan Balzarini & Amitabh Jha. (2014) All trans 1-(3-arylacryloyl)-3,5-bis(pyridin-4-ylmethylene)piperidin-4-ones as curcumin-inspired antineoplastics. European Journal of Medicinal Chemistry 87, pages 461-470.
Crossref
Neelakandan Vidhya Lakshmi, G.A. Suganya Josephine & Paramasivan T. Perumal. (2012) Novel route to spiropiperidines using N-methyl-4-piperidone, malononitrile and electrophiles. Tetrahedron Letters 53:10, pages 1282-1286.
Crossref
Ju-feng Sun, Juan Xing & Jing-tian Han. (2011) 1-Benzyl-3,5-bis(4-methylbenzylidene)-4-oxopiperidin-1-ium chloride acetic acid monosolvate. Acta Crystallographica Section E Structure Reports Online 67:6, pages o1350-o1350.
Crossref
Michael V. Makarov, Evgeniya S. Leonova, Ekaterina Yu. Rybalkina, Paul Tongwa, Victor N. Khrustalev, Tatiana V. Timofeeva & Irina L. Odinets. (2010) Synthesis, characterization and structure–activity relationship of novel N-phosphorylated E,E-3,5-bis(thienylidene)piperid-4-ones. European Journal of Medicinal Chemistry 45:3, pages 992-1000.
Crossref
Amitabh Jha, Chandrani Mukherjee, Ashok K. Prasad, Virinder S. Parmar, Manjula Vadaparti, Umashankar Das, Erik De Clercq, Jan Balzarini, James P. Stables, Anuraag Shrivastav, Rajendra K. Sharma & Jonathan R. Dimmock. (2010) Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore. Bioorganic & Medicinal Chemistry Letters 20:5, pages 1510-1515.
Crossref
Dani Youssef, Elizabeth Potter, Mamta Jha, Erik De Clercq, Jan Balzarini, James P. Stables & Amitabh Jha. (2009) Design, synthesis and bioevaluation of novel maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones as cytostatic agents. Bioorganic & Medicinal Chemistry Letters 19:22, pages 6364-6367.
Crossref
Michael V. Makarov, Irina L. Odinets, Konstantin A. Lyssenko, Ekaterina Yu. Rybalkina, Ilya V. Kosilkin, Mikhail Yu. Antipin & Tatiana V. Timofeeva. (2009) N‐alkylated 3,5‐bis(arylidene)‐4‐piperidones. Synthetic approaches, X‐ray structure and anticancer activity. Journal of Heterocyclic Chemistry 45:3, pages 729-736.
Crossref
Raju Ranjith Kumar & Subbu Perumal. (2007) Sacrificial azomethine ylide cycloaddition controlled chemoselective nitrile oxide cycloaddition to 1-methyl-3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones: formation of mono-spiro-isoxazolines. Tetrahedron 63:49, pages 12220-12231.
Crossref
Ponniah Selvakumar, Ashakumary Lakshmikuttyamma, Anuraag Shrivastav, Shankar B. Das, Jonathan R. Dimmock & Rajendra K. Sharma. (2007) Potential role of N-myristoyltransferase in cancer. Progress in Lipid Research 46:1, pages 1-36.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.