Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 21, 2006 - Issue 5
Submit an article Journal homepage
652
Views
13
CrossRef citations to date
0
Altmetric
Research Article

A kinetic, modeling and mechanistic re-analysis of thymidine phosphorylase and some related enzymes

REVIEW ARTICLE

Philip N. Edwards School of Pharmacy & Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester, M13 9PL, UK
Pages 483-518 | Received 08 Aug 2005, Accepted 24 Feb 2006, Published online: 20 Oct 2008

Citations (13)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

NatalyaG. Panova, CyrilS. Alexeev, KonstantinM. Polyakov, SergeiA. Gavryushov, AnatoliyM. Kritzyn & SergeyN. Mikhailov. (2008) Substrate Specificity of Thymidine Phosphorylase of E. Coli: Role of Hydroxyl Groups. Nucleosides, Nucleotides & Nucleic Acids 27:12, pages 1211-1214.
Read now

Articles from other publishers (12)

Felix Kaspar, Margarita Seeger, Sarah Westarp, Christoph Köllmann, Anna P. Lehmann, Patrick Pausch, Sebastian Kemper, Peter Neubauer, Gert Bange, Anett Schallmey, Daniel B. Werz & Anke Kurreck. (2021) Diversification of 4′-Methylated Nucleosides by Nucleoside Phosphorylases. ACS Catalysis 11:17, pages 10830-10835.
Crossref
Felix Kaspar, Darian S. Wolff, Peter Neubauer, Anke Kurreck & Vickery L. Arcus. (2021) pH-Independent Heat Capacity Changes during Phosphorolysis Catalyzed by the Pyrimidine Nucleoside Phosphorylase from Geobacillus thermoglucosidasius . Biochemistry 60:20, pages 1573-1577.
Crossref
Vladimir A Stepchenko, Anatoly I Miroshnikov, Frank Seela & Igor A Mikhailopulo. (2016) Enzymatic synthesis and phosphorolysis of 4(2)-thioxo- and 6(5)-azapyrimidine nucleosides by E. coli nucleoside phosphorylases . Beilstein Journal of Organic Chemistry 12, pages 2588-2601.
Crossref
Alicja Stachelska-Wierzchowska, Jacek Wierzchowski, Agnieszka Bzowska & Beata Wielgus-Kutrowska. (2015) Site-Selective Ribosylation of Fluorescent Nucleobase Analogs Using Purine-Nucleoside Phosphorylase as a Catalyst: Effects of Point Mutations. Molecules 21:1, pages 44.
Crossref
Jacek Wierzchowski, Jan M. Antosiewicz & David Shugar. (2014) 8-Azapurines as isosteric purine fluorescent probes for nucleic acid and enzymatic research. Mol. BioSyst. 10:11, pages 2756-2774.
Crossref
Yanhui Yang, Yu Chen, Herve Aloysius, Daigo Inoyama & Longqin Hu. 2013. Enzyme Technologies. Enzyme Technologies 163 235 .
Rafael G. Silva, Jennifer S. Hirschi, Mahmoud Ghanem, Andrew S. Murkin & Vern L. Schramm. (2011) Arsenate and Phosphate as Nucleophiles at the Transition States of Human Purine Nucleoside Phosphorylase. Biochemistry 50:13, pages 2701-2709.
Crossref
Igor A. Mikhailopulo & Anatoly I. Miroshnikov. (2011) Biologically important nucleosides: modern trends in biotechnology and application. Mendeleev Communications 21:2, pages 57-68.
Crossref
Michael C. FlickingerJose‐Vicente Sinisterra, Andrés‐Rafael Alcántara, Marcos Almendros, María J. Hernáiz, José‐María Sánchez‐Montero & Jorge Trelles. 2009. Encyclopedia of Industrial Biotechnology. Encyclopedia of Industrial Biotechnology 1 32 .
Harsh V. Jain, Roshni Rasheed & Thomas I. Kalman. (2010) The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism. Bioorganic & Medicinal Chemistry Letters 20:5, pages 1648-1651.
Crossref
Takahiro Mukai, Masato Taketomi, Masaaki Tashiro, Fumihiko Yamamoto & Minoru Maeda. (2009) 6‐[(2‐Iminopyrrolidinyl)methyl]‐5‐[ 125 I]iodouracil as a potential thymidine phosphorylase‐targeted radiopharmaceutical: synthesis and preliminary biological evaluation . Journal of Labelled Compounds and Radiopharmaceuticals 52:5, pages 146-150.
Crossref
Vern L Schramm. (2007) Binding isotope effects: boon and bane. Current Opinion in Chemical Biology 11:5, pages 529-536.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.