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Research Article

Molecular modifications of 2-arylidene-1-indanones leading to increased cytotoxic potencies

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Pages 37-42 | Received 25 May 2006, Accepted 01 Aug 2006, Published online: 04 Oct 2008

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M.C. Andreazza Costa, M. Miguel Castro Ferreira, R.R. Teixeira, A.P. Martins de Souza, A. Ramos de Aguiar, D. R. da Silva, C.M. Jonsson & S.C.N. Queiroz. (2021) Synthesis, biological activity, and four-dimensional quantitative structure–activity analysis of 2-arylidene indan-1,3-dione derivatives tested against Daphnia magna. SAR and QSAR in Environmental Research 32:2, pages 133-150.
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Bagrat A. Shainyan & Mark V. Sigalov. (2022) Hydrogen bonding-assisted transformations of cyclic chalcones: E/Z-isomerization, self-association and unusual tautomerism. Russian Chemical Reviews 91:5, pages RCR5035.
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Ana P. M. Souza, Maria C. A. Costa, Alex R. Aguiar, Gustavo C. Bressan, Graziela D. Almeida Lima, Wallace P. Lima, Maria P. G. Borsodi, Bartira R. Bergmann, Márcia M. C. Ferreira & Róbson R. Teixeira. (2021) Leishmanicidal and cytotoxic activities and 4D‐QSAR of 2‐arylidene indan‐1,3‐diones. Archiv der Pharmazie 354:10, pages 2100081.
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N. N. Chipanina, L. P. Oznobikhina, M. V. Sigalov, V. Yu. Serykh & B. A. Shainyan. (2021) Electron and Proton Donating Ability of the Pyrrolyl and Diazolyl Derivatives of Cycloalkanones. Russian Journal of General Chemistry 91:6, pages 991-1008.
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Olympia Kouzi, Eleni Pontiki & Dimitra Hadjipavlou-Litina. (2019) 2-Arylidene-1-indandiones as Pleiotropic Agents with Antioxidant and Inhibitory Enzymes Activities. Molecules 24:23, pages 4411.
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Wen-Juan Yang, Hui-Lin Fang, Jing Sun & Chao-Guo Yan. (2019) Construction of Dispiro-Indenone Scaffolds via Domino Cycloaddition Reactions of α,β-Unsaturated Aldimines with 2-Arylidene-1,3-indenediones and 2,2′-(Arylmethylene)bis(1,3-indenediones). ACS Omega 4:8, pages 13553-13569.
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Prasanna Rajagopalan, Abdulrahim Hakami, Mohammed Ragab & Ashraf Elbessoumy. (2019) FCY-302, a Novel Small Molecule, Induces Apoptosis in Leukemia and Myeloma Cells by Attenuating Key Antioxidant and Mitochondrial Enzymes. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 27:8, pages 957-964.
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Prasanna Rajagopalan & Harish C. Chandramoorthy. (2019) (2 E )-2-Benzylidene-4,7-dimethyl-2,3-dihydro-1 H -inden-1-one (MLT-401), a novel arylidene indanone derivative, scavenges free radicals and exhibits antiproliferative activity of Jurkat cells . Asian Biomedicine 13:4, pages 131-139.
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Mark V. Sigalov, Bagrat A. Shainyan, Nina N. Chipanina & Larisa P. Oznobikhina. (2017) Molecular Structure, Intramolecular Hydrogen Bonding, Solvent-Induced Isomerization, and Tautomerism in Azolylmethylidene Derivatives of 2-Indanone. European Journal of Organic Chemistry 2017:10, pages 1353-1364.
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Mark Sigalov, Bagrat Shainyan, Nina Chipanina, Larisa Oznobikhina, Natalia Strashnikova & Irina Sterkhova. (2015) Molecular Structure and Photoinduced Intramolecular Hydrogen Bonding in 2-Pyrrolylmethylidene Cycloalkanones. The Journal of Organic Chemistry 80:21, pages 10521-10535.
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Madhuri Barge & Rajashri Salunkhe. (2014) Aqueous extract of Balanites roxburghii fruit: a green dispersant for C–C bond formation. RSC Adv. 4:59, pages 31177-31183.
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Nian-hua Luo, Xiang Sun, Wen-tao Wei, Xue-jing Zhang & Ming Yan. (2013) Asymmetric synthesis of multicyclic spiro-1,3-indandiones via a cascade Michael/Michael reaction of curcumins and 2-arylidene-1,3-indandiones. Tetrahedron: Asymmetry 24:7, pages 402-408.
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Peng Hui Yang, Qun Zheng Zhang & Wei Sun. (2011) Clean synthesis of 2-arylideneindan-1,3-diones in water. Research on Chemical Intermediates 38:3-5, pages 1063-1068.
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Hari N. Pati, Umashankar Das, Hiroshi Sakagami, Masame Kawase, Qing Chu, Qintao Wang, James P. Stables & Jonathan R. Dimmock. (2010) 1,3‐Diaryl‐2‐propenones and 2‐Benzylidene‐1,3‐indandiones: A Quest for Compounds Displaying Greater Toxicity to Neoplasms than Normal Cells. Archiv der Pharmazie 343:9, pages 535-541.
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Hari Pati, Bijay Mishra & Vijay Satam. (2009) Synthesis of 2-[4-(4-Chlorophenyl)piperazin-1-yl]-2-methylpropanoic Acid Ethyl Ester. Molbank 2009:3, pages M607.
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