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Research Article

Novel benzothiazolyl urea and thiourea derivatives with potential cytotoxic and antimicrobial activities

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Pages 57-64 | Received 09 Jul 2006, Accepted 10 Aug 2006, Published online: 04 Oct 2008

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Ranjan K. Mohapatra, Pradeep K. Das, Manoj K. Pradhan, Marei M. El-Ajaily, Debadutta Das, Halima F. Salem, Umakanta Mahanta, Gouranga Badhei, Pankaj K. Parhi, Abdussalam A. Maihub & Md. Kudrat -E-Zahan. (2019) Recent Advances in Urea- and Thiourea-Based Metal Complexes: Biological, Sensor, Optical, and Corroson Inhibition Studies. Comments on Inorganic Chemistry 39:3, pages 127-187.
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Raja Solomon Viswas, Sheetal Pundir & Hoyun Lee. (2019) Design and synthesis of 4-piperazinyl quinoline derived urea/thioureas for anti-breast cancer activity by a hybrid pharmacophore approach. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 620-630.
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S. Bondock, W. Fadaly & M. A. Metwally. (2009) Recent trends in the chemistry of 2-aminobenzothiazoles. Journal of Sulfur Chemistry 30:1, pages 74-107.
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Shilah Bonnett, Jo-Ann Jee, Somsundaram Chettiar, Yulia Ovechkina, Aaron Korkegian, Eric Greve, Joshua Odingo & Tanya Parish. (2023) Identification of 2-Amino Benzothiazoles with Bactericidal Activity against Mycobacterium tuberculosis. Microbiology Spectrum.
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Mahesh Bhat & Shiddappa Lagamappa Belagali. (2020) Structural Activity Relationship and Importance of Benzothiazole Derivatives in Medicinal Chemistry: A Comprehensive Review. Mini-Reviews in Organic Chemistry 17:3, pages 323-350.
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H. B′Bhatt & S. Sharma. (2017) 2-(5-Chlorobenzo[ d ]thiazol-2-ylimino)thiazolidin-4-one derivatives as an antimicrobial agent. Arabian Journal of Chemistry 10, pages S531-S538.
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Kamal M. DAWOOD, Eman A. RAGAB & Korany A. ALI. (2016) Synthetic access to some new benzothiazole-based 1,3,4-thiadiazole and 1,3-thiazole derivatives. TURKISH JOURNAL OF CHEMISTRY 40, pages 277-282.
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Khaled R.A. Abdellatif, Ghada A. Abd El Wareth, Ossama M. El-Badry, Hamdy M. Ragab & Mervat M. El-Enany. (2015) Synthesis and antimicrobial evaluation of certain purine, benzothiazole and thiazole systems substituted with dialkylaminoalkyl-o-cresols. Beni-Suef University Journal of Basic and Applied Sciences 4:1, pages 52-59.
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Rangappa S. Keri, Mahadeo R. Patil, Siddappa A. Patil & Srinivasa Budagumpi. (2015) A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry. European Journal of Medicinal Chemistry 89, pages 207-251.
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D. Suresh Babu, Doddaga Srinivasulu & Venkata S. Kotakadi. (2015) Synthesis of novel N-aryl-4-[6-(2-fluoropyridin-3-yl)quinazolin-2-yl]-piperazine-1-carboxamide or -carbothioamide derivatives and their antimicrobial activity. Chemistry of Heterocyclic Compounds 51:1, pages 60-66.
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Ahmed Kamal, Md. Ashraf, M. Naseer Ahmed Khan, Vijaykumar D. Nimbarte, Shaikh Faazil, N. V. Subba Reddy & Shaik Taj. (2014) Retracted: Synthesis and Cytotoxic Activity of 2-Anilinopyridine-3-Acrylamides as Tubulin Polymerization Inhibitors. ChemMedChem 9:7, pages 1615-1615.
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Ähmed Kamal, Md. Ashraf, M.V.P.S. Vishnu Vardhan, Shaikh Faazil & V. Lakshma Nayak. (2014) Synthesis and anticancer potential of benzothiazole linked phenylpyridopyrimidinones and their diones as mitochondrial apoptotic inducers. Bioorganic & Medicinal Chemistry Letters 24:1, pages 147-151.
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Ahmed Kamal, Jaki R. Tamboli, V. Lakshma Nayak, S.F. Adil, M.V.P.S. Vishnuvardhan & S. Ramakrishna. (2013) Synthesis of pyrazolo[1,5-a]pyrimidine linked aminobenzothiazole conjugates as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters 23:11, pages 3208-3215.
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Ion Anghel, Carmen Limban, Alexandru Mihai Grumezescu, Alina Georgiana Anghel, Coralia Bleotu & Mariana Carmen Chifiriuc. (2012) In vitro evaluation of anti-pathogenic surface coating nanofluid, obtained by combining Fe3O4/C12 nanostructures and 2-((4-ethylphenoxy)methyl)-N-(substituted-phenylcarbamothioyl)-benzamides. Nanoscale Research Letters 7:1.
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José M. Vega-Pérez, Ignacio Periñán, Montserrat Argandoña, Margarita Vega-Holm, Carlos Palo-Nieto, Estefanía Burgos-Morón, Miguel López-Lázaro, Carmen Vargas, Joaquín J. Nieto & Fernando Iglesias-Guerra. (2012) Isoprenyl-thiourea and urea derivatives as new farnesyl diphosphate analogues: Synthesis and in vitro antimicrobial and cytotoxic activities. European Journal of Medicinal Chemistry 58, pages 591-612.
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Ahmed Kamal, Y.V.V. Srikanth, M. Naseer Ahmed Khan, Md. Ashraf, M. Kashi Reddy, Farheen Sultana, Tandeep Kaur, Gousia Chashoo, Nitasha Suri, Irum Sehar, Zahoor A. Wani, Arpita Saxena, Parduman R. Sharma, Shashi Bhushan, Dilip M. Mondhe & Ajit K. Saxena. (2011) 2-Anilinonicotinyl linked 2-aminobenzothiazoles and [1,2,4]triazolo[1,5-b] [1,2,4]benzothiadiazine conjugates as potential mitochondrial apoptotic inducers. Bioorganic & Medicinal Chemistry 19:23, pages 7136-7150.
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Elena L. Luzina & Anatoliy V. Popov. (2009) Synthesis and anticancer activity of N-bis(trifluoromethyl)alkyl-N′-thiazolyl and N-bis(trifluoromethyl)alkyl-N′-benzothiazolyl ureas. European Journal of Medicinal Chemistry 44:12, pages 4944-4953.
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Ahmed Kamal, Mohammed Naseer A. Khan, Yellamelli V. V. Srikanth & Shetti V. C. R. N. C. Rajesh. (2009) Synthesis and Biological Evaluation of Mercapto Triazolo-Benzothiadiazine Linked Aminobenzothiazoles as Potential Anticancer Agents. Chemical Biology & Drug Design 73:6, pages 687-693.
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