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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 22, 2007 - Issue 5
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Research Article

Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells

Mary J. Meegan Trinity College Dublin, School of Pharmacy and Pharmaceutical Sciences, Centre for Synthesis and Chemical Biology, Dublin, 2, Ireland
,
Irene Barrett Trinity College Dublin, School of Pharmacy and Pharmaceutical Sciences, Centre for Synthesis and Chemical Biology, Dublin, 2, Ireland
,
Jochen Zimmermann Trinity College Dublin, School of Pharmacy and Pharmaceutical Sciences, Centre for Synthesis and Chemical Biology, Dublin, 2, Ireland
,
Andrew J.S. Knox Trinity College Dublin, School of Pharmacy and Pharmaceutical Sciences, Centre for Synthesis and Chemical Biology, Dublin, 2, Ireland; School of Biochemistry & Immunology, Trinity College Dublin, Dublin 2, Ireland
,
Daniela M. Zisterer School of Biochemistry & Immunology, Trinity College Dublin, Dublin 2, Ireland
&
David G. Lloyd School of Biochemistry & Immunology, Trinity College Dublin, Dublin 2, Ireland
Pages 655-666 | Received 08 Mar 2007, Accepted 17 Apr 2007, Published online: 04 Oct 2008

Citations (9)

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Read on this site (2)

Irene Barrett, Miriam Carr, Niamh O’Boyle, Lisa M. Greene, Andrew J. S. Knox, David G. Lloyd, Daniela M. Zisterer & Mary J. Meegan. (2010) Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects. Journal of Enzyme Inhibition and Medicinal Chemistry 25:2, pages 180-194.
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Mary J. Meegan, Miriam Carr, Andrew J. S. Knox, Daniela M. Zisterer & David G. Lloyd. (2008) β-Lactam type molecular scaffolds for antiproliferative activity: Synthesis and cytotoxic effects in breast cancer cells. Journal of Enzyme Inhibition and Medicinal Chemistry 23:5, pages 668-685.
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Articles from other publishers (7)

Donald J. AbrahamCarlo I. Rosales, Lauren M. Gutgesell, Kiira M. Ratia & Gregory R.J. Thatcher. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 74 .
Niamh M. O’Boyle, Irene Barrett, Lisa M. Greene, Miriam Carr, Darren Fayne, Brendan Twamley, Andrew J. S. Knox, Niall O. Keely, Daniela M. Zisterer & Mary J. Meegan. (2017) Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity. Journal of Medicinal Chemistry 61:2, pages 514-534.
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Shagufta & Irshad Ahmad. (2018) Tamoxifen a pioneering drug: An update on the therapeutic potential of tamoxifen derivatives. European Journal of Medicinal Chemistry 143, pages 515-531.
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Mohd. Imran Ansari, Mohd. Kamil Hussain, Ashutosh Arun, Bandana Chakravarti, Rituraj Konwar & K. Hajela. (2015) Synthesis of targeted dibenzo[b,f]thiepines and dibenzo[b,f]oxepines as potential lead molecules with promising anti-breast cancer activity. European Journal of Medicinal Chemistry 99, pages 113-124.
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Horst Pick, Sylvain Etter, Olivia Baud, Ralf Schmauder, Lorenza Bordoli, Torsten Schwede & Horst Vogel. (2009) Dual Activities of Odorants on Olfactory and Nuclear Hormone Receptors. Journal of Biological Chemistry 284:44, pages 30547-30555.
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Jason A. Smith & John H. Ryan. 2009. A critical review of the 2007 literature preceded by two chapters on current heterocyclic topics. A critical review of the 2007 literature preceded by two chapters on current heterocyclic topics 432 458 .
Irene Barrett, Mary J. Meegan, Rosario B. Hughes, Miriam Carr, Andrew J.S. Knox, Natalia Artemenko, Georgia Golfis, Daniela M. Zisterer & David G. Lloyd. (2008) Synthesis, biological evaluation, structural–activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators. Bioorganic & Medicinal Chemistry 16:21, pages 9554-9573.
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