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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 24, 2009 - Issue 1
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Research Article

New N4-substituted piperazine naphthamide derivatives as BACE-1 inhibitors

Y. Laras Laboratoire de Chimie Biomoléculaire, Faculté des Sciences Luminy, IBDML-UMR-6216-CNRS, Université de la Méditerranée, Marseille Cedex, France
,
C. Garino Laboratoire de Chimie Bioorganique, UMR 7175-LC1 CNRS, Faculté de Pharmacie, Université Louis Pasteur, BP 60024, 67401 Illkirch Cedex, France
,
J. Dessolin Université Bordeaux 1-ENITAB, Institut Européen de Chimie et Biologie (IECB), 2 rue Robert Escarpit, 33607 Pessac Cedex, France
,
C. Weck Laboratoire de Chimie Biomoléculaire, Faculté des Sciences Luminy, IBDML-UMR-6216-CNRS, Université de la Méditerranée, Marseille Cedex, France
,
V. Moret Laboratoire de Chimie Biomoléculaire, Faculté des Sciences Luminy, IBDML-UMR-6216-CNRS, Université de la Méditerranée, Marseille Cedex, France
,
A. Rolland Laboratoire de Chimie Biomoléculaire, Faculté des Sciences Luminy, IBDML-UMR-6216-CNRS, Université de la Méditerranée, Marseille Cedex, France
&
J.-L. Kraus Laboratoire de Chimie Biomoléculaire, Faculté des Sciences Luminy, IBDML-UMR-6216-CNRS, Université de la Méditerranée, Marseille Cedex, FranceCorrespondence[email protected]
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Pages 181-187 | Received 20 Aug 2007, Accepted 08 Oct 2007, Published online: 01 Feb 2009

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Olga V. Nevzglyadova, Ekaterina V. Mikhailova, Triana R. Amen, Valeriy V. Zenin, Alexey V. Artemov, Elena I. Kostyleva, Daria A. Mezhenskaya, Dmitry I. Rodin, Alsu F. Saifitdinova, Mikhail A. Khodorkovskii, Svetlana V. Sarantseva & Tonu R. Soidla. (2015) Yeast red pigment modifies Amyloid beta growth in Alzheimer disease models in both Saccharomyces cerevisiae and Drosophila melanogaster. Amyloid 22:2, pages 100-111.
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Mariana G. Fronza, Diego Alves, Domenico Praticò & Lucielli Savegnago. (2023) The neurobiology and therapeutic potential of multi-targeting β-secretase, glycogen synthase kinase 3β and acetylcholinesterase in Alzheimer’s disease. Ageing Research Reviews 90, pages 102033.
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Olga V. Nevzglyadova, Ekaterina V. Mikhailova & Tonu R. Soidla. (2022) Yeast red pigment, protein aggregates, and amyloidoses: a review. Cell and Tissue Research 388:2, pages 211-223.
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Eva Mezeiova, Katarina Chalupova, Eugenie Nepovimova, Lukas Gorecki, Lukas Prchal, David Malinak, Kamil Kuca, Ondrej Soukup & Jan Korabecny. (2019) Donepezil Derivatives Targeting Amyloid-β Cascade in Alzheimer's Disease. Current Alzheimer Research 16:9, pages 772-800.
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Ümide Demir Özkay, Özgür Devrim Can, Begüm Nurpelin Sağlık & Nazlı Turan. (2017) A benzothiazole/piperazine derivative with acetylcholinesterase inhibitory activity: Improvement in streptozotocin-induced cognitive deficits in rats. Pharmacological Reports 69:6, pages 1349-1356.
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Rahul Shukla, Aamer Saeed, Jim Simpson & Deepak Chopra. (2017) Quantitative investigation of C–H⋯π and other intermolecular interactions in a series of crystalline N-(substituted phenyl)-2-naphthamide derivatives. CrystEngComm 19:36, pages 5473-5491.
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Dawid Panek, Anna Więckowska, Tomasz Wichur, Marek Bajda, Justyna Godyń, Jakub Jończyk, Kamil Mika, Jana Janockova, Ondrej Soukup, Damijan Knez, Jan Korabecny, Stanislav Gobec & Barbara Malawska. (2017) Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation. European Journal of Medicinal Chemistry 125, pages 676-695.
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Poonam Meena, Apra Manral, Vikas Saini & Manisha Tiwari. (2014) Protective Effects of a Piperazine Derivative [N-{4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-phenyl} Carbamic Acid Ethyl Ester] Against Aluminium-Induced Neurotoxicity: Insights From In Silico and In Vivo Studies. Neurotoxicity Research 27:3, pages 314-327.
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D. I. Rodin, A. L. Schvarzman & S. V. Saranzeva. (2014) Modern approach in the therapy of Alzheimer's disease. The Scientific Notes of the I. P. Pavlov St. Petersburg State Medical University 21:1, pages 6-10.
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Fabienne Leidel, Martin Eiden, Markus Geissen, Thomas Hirschberger, Paul Tavan, Armin Giese, Hans A. Kretzschmar, Hermann Schätzl & Martin H. Groschup. (2014) Piperazine derivatives inhibit PrP/PrPres propagation in vitro and in vivo. Biochemical and Biophysical Research Communications 445:1, pages 23-29.
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Jihong KangSerge Rivest. (2012) Lipid Metabolism and Neuroinflammation in Alzheimer's Disease: A Role for Liver X Receptors. Endocrine Reviews 33:5, pages 715-746.
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Ümide Demir Özkay, Özgür Devrim Can, Yusuf Özkay & Yusuf Öztürk. (2012) Effect of benzothiazole/piperazine derivatives on intracerebroventricular streptozotocin-induced cognitive deficits. Pharmacological Reports 64:4, pages 834-847.
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Daniela Galimberti & Elio Scarpini. (2011) Disease-modifying treatments for Alzheimer’s disease. Therapeutic Advances in Neurological Disorders 4:4, pages 203-216.
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