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Research Article

A comparison of the reactivating and therapeutic efficacy of newly developed bispyridinium oximes (K250, K251) with commonly used oximes against tabun in rats and mice

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Pages 1040-1044 | Received 31 Jul 2008, Accepted 13 Oct 2008, Published online: 24 Jun 2009

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Read on this site (2)

Jiri Kassa, Jan Misik, Jana Hatlapatkova & Jana Zdarova Karasova. (2017) A comparison of neuroprotective efficacy of two novel reactivators of acetylcholinesterase called K920 and K923 with the oxime K203 and trimedoxime in tabun-poisoned rats. Toxicology Mechanisms and Methods 27:3, pages 236-243.
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Kamil Kuca, Kamil Musilek, Daniel Jun, Miroslav Pohanka, Kallol Kumar Ghosh & Martina Hrabinova. (2010) Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase. Journal of Enzyme Inhibition and Medicinal Chemistry 25:4, pages 509-512.
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Articles from other publishers (8)

Kamil Kuca, Jorge Alberto Valle da Silva, Eugenie Nepovimova, Ngoc Lam Pham, Wenda Wu, Martin Valis, Qinghua Wu & Tanos Celmar Costa França. (2023) Pralidoxime-like reactivator with increased lipophilicity - Molecular modeling and in vitro study. Chemico-Biological Interactions, pages 110734.
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José Daniel Figueroa-Villar, Elaine C. Petronilho, Kamil Kuca & Tanos C.C. Franca. (2021) Review about Structure and Evaluation of Reactivators of Acetylcholinesterase Inhibited with Neurotoxic Organophosphorus Compounds. Current Medicinal Chemistry 28:7, pages 1422-1442.
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Jiri Kassa, Vendula Sepsova, Anna Horova & Kamil Musilek. (2015) A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K920, K923) with the oxime K203 and trimedoxime in tabun-poisoned rats and mice. Journal of Applied Biomedicine 13:4, pages 299-304.
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Jiri Kassa, Vendula Sepsova, Martina Tumova, Anna Horova & Kamil Musilek. (2015) A Comparison of the Reactivating and Therapeutic Efficacy of Two Newly Developed Oximes (K727 and K733) with Oxime K203 and Trimedoxime in Tabun-Poisoned Rats and Mice. Basic & Clinical Pharmacology & Toxicology 116:4, pages 367-371.
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Jiří Kassa, Jana Hatlapatková & Jana Žďárová Karasová. (2015) The Evaluation of the Potency of Newly Developed Oximes (K727, K733) and Trimedoxime to Counteract Acute Neurotoxic Effects of Tabun in Rats. Acta Medica (Hradec Kralove, Czech Republic) 58:4, pages 135-143.
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Kamil Musilek, Martin Dolezal, Frank Gunn‐Moore & Kamil Kuca. (2011) Design, evaluation and structure—Activity relationship studies of the AChE reactivators against organophosphorus pesticides. Medicinal Research Reviews 31:4, pages 548-575.
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Guillaume Mercey, Tristan Verdelet, Géraldine Saint-André, Emilie Gillon, Alain Wagner, Rachid Baati, Ludovic Jean, Florian Nachon & Pierre-Yves Renard. (2011) First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase. Chemical Communications 47:18, pages 5295.
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Jiri Bajgar, Jana Zdarova Karasova, Jiri Kassa, Jiri Cabal, Josef Fusek, Vaclav Blaha & Sandra Tesarova. (2010) Tabun-inhibited rat tissue and blood cholinesterases and their reactivation with the combination of trimedoxime and HI-6 in vivo. Chemico-Biological Interactions 187:1-3, pages 287-290.
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