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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue sup2
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Short Communication

Identification of Mycobacterium tuberculosis leucyl-tRNA synthetase (LeuRS) inhibitors among the derivatives of 5-phenylamino-2H-[1,2,4]triazin-3-one

Olga I. GudzeraInstitute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv, Ukraine and
,
Andriy G. GolubOTAVA Ltd., Vaughan, ON, Canada
,
Volodymyr G. BdzholaInstitute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv, Ukraine and
,
Galyna P. VolynetsInstitute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv, Ukraine and
,
Oksana P. KovalenkoInstitute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv, Ukraine and
,
Konstantin S. BoyarshinInstitute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv, Ukraine and
,
Anna D. YaremchukInstitute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv, Ukraine and
,
Mykola V. ProtopopovInstitute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv, Ukraine and
,
Sergiy M. YarmolukInstitute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv, Ukraine and Correspondence[email protected]
&
Michail A. TukaloInstitute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv, Ukraine and
show all
Pages 201-207 | Received 22 Mar 2016, Accepted 09 May 2016, Published online: 31 May 2016

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Alexey Aleksandrov & Hannu Myllykallio. (2019) Advances and challenges in drug design against tuberculosis: application of in silico approaches. Expert Opinion on Drug Discovery 14:1, pages 35-46.
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Articles from other publishers (16)

Shivani Thakur & Rukmankesh Mehra. (2023) Computational Insight into Substrate-Induced Conformational Changes in Methionyl-tRNA Synthetase of Mycobacterium Tuberculosis. The Protein Journal 42:5, pages 533-546.
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Jiaxing Yang, Laiying Zhang, Wenliang Qiao & Youfu Luo. (2023) Mycobacterium tuberculosis : Pathogenesis and therapeutic targets . MedComm 4:5.
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Dongmin Kim, Tawni L. Crippen, Laxmi Dhungel, Pablo J. Delclos, Jeffery K. Tomberlin & Heather R. Jordan. (2023) Behavioral interplay between mosquito and mycolactone produced by Mycobacterium ulcerans and bacterial gene expression induced by mosquito proximity. PLOS ONE 18:8, pages e0289768.
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Zhuo He, Dai-Chuan Huang, Dale Guo, Fang Deng, Qiang Sha, Ming-Zhi Zhang, Wei-Hua Zhang & Yu-Cheng Gu. (2023) Synthesis, fungicidal activity and molecular docking studies of tavaborole derivatives. Advanced Agrochem 2:2, pages 185-195.
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Francesca G. Tomasi & Eric J. Rubin. (2022) Failing upwards: Genetics-based strategies to improve antibiotic discovery and efficacy in Mycobacterium tuberculosis. Frontiers in Cellular and Infection Microbiology 12.
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Galyna P Volynets, Mariia O Usenko, Olga I Gudzera, Segiy A Starosyla, Anatoliy O Balanda, Anatolii R Syniugin, Oksana B Gorbatiuk, Andrii O Prykhod'ko, Volodymyr G Bdzhola, Sergiy M Yarmoluk & Michael A Tukalo. (2022) Identification of dual-targeted Mycobacterium tuberculosis aminoacyl-tRNA synthetase inhibitors using machine learning . Future Medicinal Chemistry 14:17, pages 1223-1237.
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Faten Ahmad Alsulaimany, Haifa Almukadi, Nidal M. Omer Zabermawi, Thamer Abdulhamid Aljuhani, Omran M. Rashidi, Walaa F. Albaqami, Anwar A. Alghamdi, Aftab Ahmad, Noor Ahmad Shaik & Babajan Banaganapalli. (2022) Identification of novel mycobacterium tuberculosis leucyl-tRNA synthetase inhibitor using a knowledge-based computational screening approach. Journal of King Saud University - Science 34:4, pages 102032.
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Liu Yang, Xueping Hu, Xin Chai, Qing Ye, Jinping Pang, Dan Li & Tingjun Hou. (2022) Opportunities for overcoming tuberculosis: Emerging targets and their inhibitors. Drug Discovery Today 27:1, pages 326-336.
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Murtala A. Ejalonibu, Segun A. Ogundare, Ahmed A. Elrashedy, Morufat A. Ejalonibu, Monsurat M. Lawal, Ndumiso N. Mhlongo & Hezekiel M. Kumalo. (2021) Drug Discovery for Mycobacterium tuberculosis Using Structure-Based Computer-Aided Drug Design Approach. International Journal of Molecular Sciences 22:24, pages 13259.
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Umar Ndagi, Hezekiel M. Kumalo & Ndumiso N. Mhlongo. (2021) A consequence of drug targeting of aminoacyl‐tRNA synthetases in Mycobacterium tuberculosis . Chemical Biology & Drug Design 98:3, pages 421-434.
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Ghada Bouz & Jan Zitko. (2021) Inhibitors of aminoacyl-tRNA synthetases as antimycobacterial compounds: An up-to-date review. Bioorganic Chemistry 110, pages 104806.
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Sergey V. MelnikovDavid L. StevensXian Fu, Hui Si Kwok, Jin-Tao ZhangYue Shen, Jeffery SabinaKevin Lee, Harry Lee & Dieter Söll. (2020) Exploiting evolutionary trade-offs for posttreatment management of drug-resistant populations. Proceedings of the National Academy of Sciences 117:30, pages 17924-17931.
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Regina Zamacona, Pamela N. Chavero, Eduardo Medellin, Yanmei Hu, Casey A. Hughes, Nathalie Quach, Megan Keniry & James M. Bullard. (2020) Identification and Characterization of Chemical Compounds that Inhibit Leucyl-tRNA Synthetase from Pseudomonas aeruginosa. Current Drug Discovery Technologies 17:1, pages 119-130.
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Galyna P. Volynets, Sergiy A. Starosyla, Mariia Yu. Rybak, Volodymyr G. Bdzhola, Oksana P. Kovalenko, Vasyl S. Vdovin, Sergiy M. Yarmoluk & Michail A. Tukalo. (2019) Dual-targeted hit identification using pharmacophore screening. Journal of Computer-Aided Molecular Design 33:11, pages 955-964.
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Panpan Zhang & Shutao Ma. (2019) Recent development of leucyl-tRNA synthetase inhibitors as antimicrobial agents. MedChemComm 10:8, pages 1329-1341.
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Simon F.K. Lee, Barbara E. Laughon, Timothy D. McHugh & Marc Lipman. (2019) New drugs to treat difficult tuberculous and nontuberculous mycobacterial pulmonary disease. Current Opinion in Pulmonary Medicine 25:3, pages 271-280.
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