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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue sup2
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Research Article

In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells

Erzsebet Pászti-GereFaculty of Veterinary Science, Department of Pharmacology and Toxicology, Szent István University, Budapest, Hungary, Correspondence[email protected]
,
Eszter CzimmermannFaculty of Veterinary Science, Department of Pharmacology and Toxicology, Szent István University, Budapest, Hungary,
,
Gabriella UjhelyiFaculty of Pharmacy, Semmelweis University, Budapest, Hungary,
,
Peter Balla1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary, and
,
Alexander MaiwaldFaculty of Pharmacy, Institute of Pharmaceutical Chemistry, Philipps University Marburg, Marburg, Germany
&
Torsten SteinmetzerFaculty of Pharmacy, Institute of Pharmaceutical Chemistry, Philipps University Marburg, Marburg, Germany
Pages 123-129 | Received 08 Feb 2016, Accepted 17 May 2016, Published online: 09 Jun 2016

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Erzsébet Pászti-Gere, Judit Pomothy, Ákos Jerzsele, Oliver Pilgram & Torsten Steinmetzer. (2021) Exposure of human intestinal epithelial cells and primary human hepatocytes to trypsin-like serine protease inhibitors with potential antiviral effect. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 659-668.
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Articles from other publishers (12)

Nicholas van Eijk, Luna C. Schmacke, Torsten Steinmetzer, Oliver Pilgram, Miklós Poór & Erzsébet Pászti-Gere. (2023) In vitro testing of host-targeting small molecule antiviral matriptase/TMPRSS2 inhibitors in 2D and 3D cell-based assays. Biomedicine & Pharmacotherapy 168, pages 115761.
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Cecilia Pozzi, Anne Vanet, Valeria Francesconi, Lorenzo Tagliazucchi, Giusy Tassone, Alberto Venturelli, Francesca Spyrakis, Marco MazzoranaMaria P. Costi & Michele Tonelli. (2023) Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery–Genetics Alliance Perspective. Journal of Medicinal Chemistry 66:6, pages 3664-3702.
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Zsófia Fedor, Anna Szentkirályi-Tóth, Gábor Nagy, Zoltán Szimrók, Eszter Varga, Anna Pászti, Zoltán Pászti, Ákos Jerzsele, Oliver Pilgram, Torsten Steinmetzer, Gábor Mátis, Zsuzsanna Neogrády & Erzsébet Pászti-Gere. (2022) Interspecies Comparisons of the Effects of Potential Antiviral 3-Amidinophenylalanine Derivatives on Cytochrome P450 1A2 Isoenzyme. Veterinary Sciences 9:4, pages 156.
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Erzsébet Pászti-Gere, Anna Szentkirályi, Zsófia Fedor, Gábor Nagy, Zoltán Szimrók, Zoltán Pászti, Anna Pászti, Oliver Pilgram, Torsten Steinmetzer, Slávka Bodnárová, Eszter Fliszár-Nyúl & Miklós Poór. (2022) In vitro interaction of potential antiviral TMPRSS2 inhibitors with human serum albumin and cytochrome P 450 isoenzymes. Biomedicine & Pharmacotherapy 146, pages 112513.
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Ya-Ming Xu, Marielle Cascaes Inacio, Manping X. Liu & A.A. Leslie Gunatilaka. (2022) Discovery of diminazene as a dual inhibitor of SARS-CoV-2 human host proteases TMPRSS2 and furin using cell-based assays. Current Research in Chemical Biology 2, pages 100023.
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Filipa Santos, Pedro Fernandes & Maria Ramos. (2021) Enzima TMPRSS2. Revista de Ciência Elementar 9:4.
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Anna Goc, Waldemar Sumera, Matthias Rath & Aleksandra Niedzwiecki. (2021) Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions. PLOS ONE 16:6, pages e0253489.
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Jacopo Sgrignani & Andrea Cavalli. (2021) Computational Identification of a Putative Allosteric Binding Pocket in TMPRSS2. Frontiers in Molecular Biosciences 8.
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Abdul Arif Khan & Zakir Khan. (2021) Comparative host–pathogen protein–protein interaction analysis of recent coronavirus outbreaks and important host targets identification. Briefings in Bioinformatics 22:2, pages 1206-1214.
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Anna Goc, Aleksandra Niedzwiecki & Matthias Rath. (2021) Polyunsaturated ω-3 fatty acids inhibit ACE2-controlled SARS-CoV-2 binding and cellular entry. Scientific Reports 11:1.
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Tianguang Huang, Lin Sun, Dongwei Kang, Vasanthanathan Poongavanam, Xinyong Liu, Peng Zhan & Luis Menéndez-Arias. 2021. Antiviral Drug Discovery and Development. Antiviral Drug Discovery and Development 219 260 .
Steve P.H. Alexander, Jane F. Armstrong, Anthony P. Davenport, Jamie A. Davies, Elena Faccenda, Simon D. Harding, Francesca Levi‐Schaffer, Janet J. Maguire, Adam J. Pawson, Christopher Southan & Michael Spedding. (2020) A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development: IUPHAR Review 29. British Journal of Pharmacology 177:21, pages 4942-4966.
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