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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue sup4
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Original Article

Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR

Giannamaria AnnunziatoDepartment of Pharmacy, and
,
Marco PieroniDepartment of Pharmacy, and Correspondence[email protected] [email protected]
,
Roberto BenoniDepartment of Neurosciences, University of Parma, Parma, Italy,
,
Barbara CampaniniDepartment of Pharmacy, and
,
Thelma A. PertinhezDepartment of Biochemical, Biotechnological and Translational Sciences, University of Parma, Parma, Italy, ;Transfusion Medicine Unit, ASMN-IRCCS, Reggio, Emilia, Italy,
,
Chiara PecchiniDepartment of Pharmacy, and
,
Agostino BrunoDepartment of Pharmacy, and
,
Joana MagalhãesDepartment of Pharmacy, and
,
Stefano BettatiNational Institute of Biostructures and Biosystems, Rome, Italy, and
,
Nina FrankoDepartment of Pharmacy, and
,
Andrea MozzarelliDepartment of Pharmacy, and ;National Institute of Biostructures and Biosystems, Rome, Italy, and ;Institute of Biophysics, CNR, Pisa, Italy
&
Gabriele CostantinoDepartment of Pharmacy, and
show all
Pages 78-87 | Received 28 Jun 2016, Accepted 26 Jul 2016, Published online: 31 Aug 2016

Citations (21)

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Read on this site (5)

Giannamaria Annunziato & Gabriele Costantino. (2020) Antimicrobial peptides (AMPs): a patent review (2015–2020). Expert Opinion on Therapeutic Patents 30:12, pages 931-947.
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Joana Magalhães, Nina Franko, Giannamaria Annunziato, Marco Pieroni, Roberto Benoni, Anna Nikitjuka, Andrea Mozzarelli, Stefano Bettati, Anna Karawajczyk, Aigars Jirgensons, Barbara Campanini & Gabriele Costantino. (2019) Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 31-43.
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Giannamaria Annunziato, Laura Giovati, Andrea Angeli, Marialaura Pavone, Sonia Del Prete, Marco Pieroni, Clemente Capasso, Agostino Bruno, Stefania Conti, Walter Magliani, Claudiu T. Supuran & Gabriele Costantino. (2018) Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 1537-1544.
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Joana Magalhães, Nina Franko, Giannamaria Annunziato, Martin Welch, Stephen K. Dolan, Agostino Bruno, Andrea Mozzarelli, Stefano Armao, Aigars Jirgensons, Marco Pieroni, Gabriele Costantino & Barbara Campanini. (2018) Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 1444-1452.
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Nina Franko, Konstantinos Grammatoglou, Barbara Campanini, Gabriele Costantino, Aigars Jirgensons & Andrea Mozzarelli. (2018) Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 1343-1351.
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Articles from other publishers (16)

Yupian Deng, Ying Liu, Jingjing He, Pai Zheng, Zhudi Sun & Song Cao. (2023) Efficient synthesis of functionalized trifluoromethyl cyclopropanes via cyclopropanation of α-trifluoromethyl styrenes with chloroacetonitrile and ethyl chloroacetate . New Journal of Chemistry 47:35, pages 16604-16610.
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Joanna L. Hicks, Keely E.A. Oldham, Jack McGarvie & Emma J. Walker. (2022) Combatting antimicrobial resistance via the cysteine biosynthesis pathway in bacterial pathogens. Bioscience Reports 42:10.
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Marialaura Pavone, Samanta Raboni, Marialaura Marchetti, Giannamaria Annunziato, Stefano Bettati, Bianca Papotti, Cinzia Marchi, Emanuele Carosati, Marco Pieroni, Barbara Campanini & Gabriele Costantino. (2022) Exploring the chemical space around N-(5-nitrothiazol-2-yl)-1,2,3-thiadiazole-4-carboxamide, a hit compound with serine acetyltransferase (SAT) inhibitory properties. Results in Chemistry 4, pages 100443.
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Verena Nadin Fritsch & Haike Antelmann. 2022. Redox Chemistry and Biology of Thiols. Redox Chemistry and Biology of Thiols 679 711 .
Rehab H. Abd El-Aleam, Riham F. George, Hanan H. Georgey & Hamdy M. Abdel-Rahman. (2021) Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance. RSC Advances 11:58, pages 36459-36482.
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Marialaura Marchetti, Francesco Saverio De Angelis, Giannamaria Annunziato, Gabriele Costantino, Marco Pieroni, Luca Ronda, Andrea Mozzarelli, Barbara Campanini, Salvatore Cannistraro, Anna Rita Bizzarri & Stefano Bettati. (2021) A Competitive O-Acetylserine Sulfhydrylase Inhibitor Modulates the Formation of Cysteine Synthase Complex. Catalysts 11:6, pages 700.
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Joana Magalhães, Nina Franko, Samanta Raboni, Giannamaria Annunziato, Päivi Tammela, Agostino Bruno, Stefano Bettati, Stefano Armao, Costanza Spadini, Clotilde Silvia Cabassi, Andrea Mozzarelli, Marco Pieroni, Barbara Campanini & Gabriele Costantino. (2021) Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants. Pharmaceuticals 14:2, pages 174.
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Giannamaria Annunziato, Costanza Spadini, Nina Franko, Paola Storici, Nicola Demitri, Marco Pieroni, Sara Flisi, Lucrezia Rosati, Mattia Iannarelli, Marialaura Marchetti, Joana Magalhaes, Stefano Bettati, Andrea Mozzarelli, Clotilde Silvia Cabassi, Barbara Campanini & Gabriele Costantino. (2021) Investigational Studies on a Hit Compound Cyclopropane–Carboxylic Acid Derivative Targeting O -Acetylserine Sulfhydrylase as a Colistin Adjuvant . ACS Infectious Diseases 7:2, pages 281-292.
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Joana Magalhães, Nina Franko, Samanta Raboni, Giannamaria Annunziato, Päivi Tammela, Agostino Bruno, Stefano Bettati, Andrea Mozzarelli, Marco Pieroni, Barbara Campanini & Gabriele Costantino. (2020) Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O -Acetyltransferase Inhibitor . ACS Medicinal Chemistry Letters 11:5, pages 790-797.
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Annunziato. (2019) Strategies to Overcome Antimicrobial Resistance (AMR) Making Use of Non-Essential Target Inhibitors: A Review. International Journal of Molecular Sciences 20:23, pages 5844.
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Brenda Rosa, Marialaura Marchetti, Gianluca Paredi, Heinz Amenitsch, Nina Franko, Roberto Benoni, Barbara Giabbai, Maria Giovanna De Marino, Andrea Mozzarelli, Luca Ronda, Paola Storici, Barbara Campanini & Stefano Bettati. (2019) Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action. International Journal of Molecular Sciences 20:20, pages 5219.
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Pallavi Joshi, Abhinal Gupta & Vibha Gupta. (2019) Insights into multifaceted activities of CysK for therapeutic interventions. 3 Biotech 9:2.
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Dipakranjan Mal. 2019. Anionic Annulations in Organic Synthesis. Anionic Annulations in Organic Synthesis 373 414 .
Joana Magalhães, Giannamaria Annunziato, Nina Franko, Marco Pieroni, Barbara Campanini, Agostino Bruno & Gabriele Costantino. (2018) Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets. Journal of Chemical Information and Modeling 58:3, pages 710-723.
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Roberto Benoni, Christina M. Beck, Fernando Garza-Sánchez, Stefano Bettati, Andrea Mozzarelli, Christopher S. Hayes & Barbara Campanini. (2017) Activation of an anti-bacterial toxin by the biosynthetic enzyme CysK: mechanism of binding, interaction specificity and competition with cysteine synthase. Scientific Reports 7:1.
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Roberto Benoni, Omar De Bei, Gianluca Paredi, Christopher S. Hayes, Nina Franko, Andrea Mozzarelli, Stefano Bettati & Barbara Campanini. (2017) Modulation of Escherichia coli serine acetyltransferase catalytic activity in the cysteine synthase complex . FEBS Letters 591:9, pages 1212-1224.
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