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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue sup4
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Research Article

New N,N-dimethylcarbamate inhibitors of acetylcholinesterase: design synthesis and biological evaluation

Daniela De VitaDepartment Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy,
,
Fabiana PandolfiDepartment Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy,
,
Luigi OrnanoDepartment Scienze di Base e Applicate per l’Ingegneria, Sapienza University of Rome, Rome, Italy, and
,
Marta FerociDepartment Scienze di Base e Applicate per l’Ingegneria, Sapienza University of Rome, Rome, Italy, and
,
Isabella ChiarottoDepartment Scienze di Base e Applicate per l’Ingegneria, Sapienza University of Rome, Rome, Italy, and
,
Ilaria SilenoDepartment Scienze di Base e Applicate per l’Ingegneria, Sapienza University of Rome, Rome, Italy, and
,
Federico PepiDepartment Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy,
,
Roberta CostiDepartment Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy, ;Istituto Pasteur-Fondazione Cenci Bolognetti, Department Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy
,
Roberto Di SantoDepartment Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy, ;Istituto Pasteur-Fondazione Cenci Bolognetti, Department Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy
&
Luigi ScipioneDepartment Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy, Correspondence[email protected]
 show all
Pages 106-113 | Received 16 Jun 2016, Accepted 29 Jul 2016, Published online: 03 Sep 2016

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Juan Zhang, Jia-Cheng Li, Jia-Li Song, Zhi-Qiang Cheng, Ji-Zheng Sun & Cheng-Shi Jiang. (2019) Synthesis and evaluation of coumarin/1,2,4-oxadiazole hybrids as selective BChE inhibitors with neuroprotective activity. Journal of Asian Natural Products Research 21:11, pages 1090-1103.
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Articles from other publishers (10)

Marcela Šafratová, Jana Křoustková, Negar Maafi, Daniela Suchánková, Rudolf Vrabec, Jakub Chlebek, Jiří Kuneš, Lubomír Opletal, Franz Bucar & Lucie Cahlíková. (2022) Amaryllidaceae Alkaloids from Clivia miniata (Lindl.) Bosse (Amaryllidaceae): Isolation, Structural Elucidation, and Biological Activity. Plants 11:22, pages 3034.
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Martina Bortolami, Fabiana Pandolfi, Valeria Tudino, Antonella Messore, Valentina Noemi Madia, Daniela De Vita, Roberto Di Santo, Roberta Costi, Isabella Romeo, Stefano Alcaro, Marisa Colone, Annarita Stringaro, Alba Espargaró, Raimon Sabatè & Luigi Scipione. (2022) Design, Synthesis, and In Vitro, In Silico and In Cellulo Evaluation of New Pyrimidine and Pyridine Amide and Carbamate Derivatives as Multi-Functional Cholinesterase Inhibitors. Pharmaceuticals 15:6, pages 673.
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Patricia A. Vignaux, Eni Minerali, Thomas R. Lane, Daniel H. Foil, Peter B. Madrid, Ana C. Puhl & Sean Ekins. (2021) The Antiviral Drug Tilorone Is a Potent and Selective Inhibitor of Acetylcholinesterase. Chemical Research in Toxicology 34:5, pages 1296-1307.
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Lucie Cahlíková, Kateřina Breiterová & Lubomír Opletal. (2020) Chemistry and Biological Activity of Alkaloids from the Genus Lycoris (Amaryllidaceae). Molecules 25:20, pages 4797.
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Sofya V. Lushchekina & Patrick Masson. (2020) Slow-binding inhibitors of acetylcholinesterase of medical interest. Neuropharmacology 177, pages 108236.
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Fahmina Zafar, Anjali Gupta, Karthick Thangavel, Kavita Khatana, Ali Alhaji Sani, Anujit Ghosal, Poonam Tandon & Nahid Nishat. (2020) Physicochemical and Pharmacokinetic Analysis of Anacardic Acid Derivatives. ACS Omega 5:11, pages 6021-6030.
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Cheng-Shi Jiang, Yong-Xi Ge, Zhi-Qiang Cheng, Yin-Yin Wang, Hong-Rui Tao, Kongkai Zhu & Hua Zhang. (2019) Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-Aβ Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation. Molecules 24:14, pages 2568.
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Cheng-Shi Jiang, Yong-Xi Ge, Zhi-Qiang Cheng, Jia-Li Song, Yin-Yin Wang, Kongkai Zhu & Hua Zhang. (2019) Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation. Journal of Computer-Aided Molecular Design 33:5, pages 521-530.
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Zhi-Qiang Cheng, Kong-Kai Zhu, Juan Zhang, Jia-Li Song, Luis Alexandre Muehlmann, Cheng-Shi Jiang, Chang-Liang Liu & Hua Zhang. (2019) Molecular-docking-guided design and synthesis of new IAA-tacrine hybrids as multifunctional AChE/BChE inhibitors. Bioorganic Chemistry 83, pages 277-288.
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Fabiana Pandolfi, Daniela De Vita, Martina Bortolami, Antonio Coluccia, Roberto Di Santo, Roberta Costi, Vincenza Andrisano, Francesco Alabiso, Christian Bergamini, Romana Fato, Manuela Bartolini & Luigi Scipione. (2017) New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation. European Journal of Medicinal Chemistry 141, pages 197-210.
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