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Research Article

Functional constituents of wild and cultivated Goji (L. barbarum L.) leaves: phytochemical characterization, biological profile, and computational studies

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Pages 153-168 | Received 01 Aug 2016, Accepted 28 Sep 2016, Published online: 18 Jan 2017

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Rusu, Fizeșan, Pop, Gheldiu, Mocan, Crișan, Vlase, Loghin, Popa & Tomuta. (2019) Enhanced Recovery of Antioxidant Compounds from Hazelnut (Corylus avellana L.) Involucre Based on Extraction Optimization: Phytochemical Profile and Biological Activities. Antioxidants 8:10, pages 460.
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Zhifeng Jia, Aorigele Chen, Chunjie Wang, Meiling He, Jin Xu, He Fu, Xin Zhang, Wenting Lv & Zhenshuang Guo. (2019) Amelioration effects of Kaempferol on immune response following chronic intermittent cold-stress. Research in Veterinary Science 125, pages 390-396.
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Xue‐qin Zhao, Sheng Guo, Hui Yan, You‐yuan Lu, Fang Zhang, Da‐wei Qian, Han‐qing Wang & Jin‐ao Duan. (2019) Analysis of phenolic acids and flavonoids in leaves of Lycium barbarum from different habitats by ultra‐high‐performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry . Biomedical Chromatography 33:8.
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Luna Pollini, Rachele Rocchi, Lina Cossignani, Jordi Mañes, Dario Compagnone & Francesca Blasi. (2019) Phenol Profiling and Nutraceutical Potential of Lycium spp. Leaf Extracts Obtained with Ultrasound and Microwave Assisted Techniques. Antioxidants 8:8, pages 260.
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Priyanka Saha, Anupam Das Talukdar, Rajat Nath, Satyajit D. Sarker, Lutfun Nahar, Jagajjit Sahu & Manabendra Dutta Choudhury. (2019) Role of Natural Phenolics in Hepatoprotection: A Mechanistic Review and Analysis of Regulatory Network of Associated Genes. Frontiers in Pharmacology 10.
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Xiao Xiao, Wei Ren, Nan Zhang, Tao Bing, Xiangjun Liu, Zhenwen Zhao & Dihua Shangguan. (2019) Comparative Study of the Chemical Constituents and Bioactivities of the Extracts from Fruits, Leaves and Root Barks of Lycium barbarum. Molecules 24:8, pages 1585.
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Waqas Mahmood, Hammad Saleem, Wardah Shahid, Irshad Ahmad, Gokhan Zengin, Mohamad Fawzi Mahomoodally, M. Ashraf & Nafees Ahemad. (2019) Clinical enzymes inhibitory activities, antioxidant potential and phytochemical profile of Vernonia oligocephala (DC.) Sch.Bip. ex Walp roots. Biocatalysis and Agricultural Biotechnology 18, pages 101039.
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C.G. Pereira, M. Locatelli, D. Innosa, F. Cacciagrano, L. Polesná, T.F. Santos, M.J. Rodrigues & L. Custódio. (2019) Unravelling the potential of the medicinal halophyte Eryngium maritimum L.: In vitro inhibition of diabetes-related enzymes, antioxidant potential, polyphenolic profile and mineral composition. South African Journal of Botany 120, pages 204-212.
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G. Zengin, A. Aktumsek, A. Mocan, K.R.R. Rengasamy, C.M.N. Picot & M.F. Mahomoodally. (2019) Asphodeline cilicica Tuzlaci: From the plant to its most active part extract and its broad bioactive properties. South African Journal of Botany 120, pages 186-190.
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Y.-Y. Zhang, K. Thakur, C.-K. Wei, H. Wang, J.-G. Zhang & Z.-J. Wei. (2019) Evaluation of inhibitory activity of natural plant polyphenols on Soybean lipoxygenase by UFLC-mass spectrometry. South African Journal of Botany 120, pages 179-185.
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M. Baessa, M.J. Rodrigues, C. Pereira, T. Santos, N. da Rosa Neng, J.M.F. Nogueira, L. Barreira, J. Varela, H. Ahmed, S. Asif, S.A. Boukhari, W.K. Kayani, Khawaja Shafique Ahmad, G. Zengin, A. Mollica & L. Custódio. (2019) A comparative study of the in vitro enzyme inhibitory and antioxidant activities of Butea monosperma (Lam.) Taub. and Sesbania grandiflora (L.) Poiret from Pakistan: New sources of natural products for public health problems. South African Journal of Botany 120, pages 146-156.
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A. Mollica, A. Stefanucci, G. Macedonio, M. Locatelli, G. Luisi, E. Novellino & G. Zengin. (2019) Chemical composition and biological activity of Capparis spinosa L. from Lipari Island. South African Journal of Botany 120, pages 135-140.
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I. Akata, G. Zengin, C.M.N. Picot & M.F. Mahomoodally. (2019) Enzyme inhibitory and antioxidant properties of six mushroom species from the Agaricaceae family. South African Journal of Botany 120, pages 95-99.
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M. Marrelli, F. Araniti, G. Statti & F. Conforti. (2019) Metabolite profiling and biological properties of aerial parts from Leopoldia comosa (L.) Parl.: Antioxidant and anti-obesity potential. South African Journal of Botany 120, pages 104-111.
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A. Cvetanović, Z. Zeković, G. Zengin, P. Mašković, M. Petronijević & M. Radojković. (2019) Multidirectional approaches on autofermented chamomile ligulate flowers: Antioxidant, antimicrobial, cytotoxic and enzyme inhibitory effects. South African Journal of Botany 120, pages 112-118.
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M.J. Rodrigues, M. Oliveira, V. Neves, A. Ovelheiro, C.A. Pereira, N.R. Neng, J.M.F. Nogueira, J. Varela, L. Barreira & L. Custódio. (2019) Coupling sea lavender (Limonium algarvense Erben) and green tea (Camellia sinensis (L.) Kuntze) to produce an innovative herbal beverage with enhanced enzymatic inhibitory properties. South African Journal of Botany 120, pages 87-94.
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Mohamad Fawzi Mahomoodally, Serife Yerlikaya, Eulogio J. Llorent-Martínez, Asli Uğurlu, Mehmet Cengiz Baloglu, Yasemin Celik Altunoglu, Adriano Mollica, Kurty Kersley Dardenne, Muhammad Zakariyyah Aumeeruddy, Daneshwar Puchooa & Gokhan Zengin. (2019) Pharmacological and polyphenolic profiles of Phyllanthus phillyreifolius var. commersonii Müll. Arg: An unexplored endemic species from Mauritius. Food Research International 115, pages 425-438.
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Hammad Saleem, Thet Thet Htar, Rakesh Naidu, Nurziana Sharmilla Nawawi, Irshad Ahmad, Muhammad Ashraf & Nafees Ahemad. (2019) Biological, chemical and toxicological perspectives on aerial and roots of Filago germanica (L.) huds: Functional approaches for novel phyto-pharmaceuticals. Food and Chemical Toxicology 123, pages 363-373.
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Gulnur Eksi, Sevinc Kurbanoglu & Sibel A. Ozkan. 2019. Engineering Tools in the Beverage Industry. Engineering Tools in the Beverage Industry 351 404 .
Mohamad Fawzi Mahomoodally, Adriano Mollica, Azzura Stefanucci, Muhammad Zakariyyah Aumeeruddy, Ramjuttun Poorneeka & Gokhan Zengin. (2018) Volatile components, pharmacological profile, and computational studies of essential oil from Aegle marmelos (Bael) leaves: A functional approach. Industrial Crops and Products 126, pages 13-21.
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Peipei Tang & M. Monica Giusti. (2018) Black goji as a potential source of natural color in a wide pH range. Food Chemistry 269, pages 419-426.
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Marius Rusu, Ana-Maria Gheldiu, Andrei Mocan, Cadmiel Moldovan, Daniela-Saveta Popa, Ioan Tomuta & Laurian Vlase. (2018) Process Optimization for Improved Phenolic Compounds Recovery from Walnut (Juglans regia L.) Septum: Phytochemical Profile and Biological Activities. Molecules 23:11, pages 2814.
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Tânia C.S.P. Pires, Maria Inês Dias, Lillian Barros, Ricardo C. Calhelha, Maria José Alves, Celestino Santos-Buelga & Isabel C.F.R. Ferreira. (2018) Phenolic compounds profile, nutritional compounds and bioactive properties of Lycium barbarum L.: A comparative study with stems and fruits. Industrial Crops and Products 122, pages 574-581.
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Gokhan Zengin, Adriano Mollica, Muhammad Zakariyyah Aumeeruddy, Kannan R.R. Rengasamy & Mohamad Fawzi Mahomoodally. (2018) Phenolic profile and pharmacological propensities of Gynandriris sisyrinchium through in vitro and in silico perspectives. Industrial Crops and Products 121, pages 328-337.
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Gokalp Ozmen Guler, Gokhan Zengin, Firat Karadag, Adriano Mollica, Carene Marie Nancy Picot & Mohamad Fawzi Mahomoodally. (2018) HPLC-DAD profiles and pharmacological insights of Onobrychis argyrea subsp isaurica extracts. Computational Biology and Chemistry 76, pages 256-263.
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Georgia Marini, Konstantia Graikou, Gökhan Zengin, George A. Karikas, Mahabir P. Gupta & Ioanna Chinou. (2018) Phytochemical analysis and biological evaluation of three selected Cordia species from Panama. Industrial Crops and Products 120, pages 84-89.
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Andrei Mocan, Alina Diuzheva, Simone Carradori, Vasil Andruch, Chiara Massafra, Cadmiel Moldovan, Cristian Sisea, Jacobus P. Petzer, Anél Petzer, Susi Zara, Guya Diletta Marconi, Gokhan Zengin, Gianina Crișan & Marcello Locatelli. (2018) Development of novel techniques to extract phenolic compounds from Romanian cultivars of Prunus domestica L. and their biological properties. Food and Chemical Toxicology 119, pages 189-198.
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Yuan-Yuan Zhang, Fang Zhang, Kiran Thakur, Ao-Te Ci, Hao Wang, Jian-Guo Zhang & Zhao-Jun Wei. (2018) Effect of natural polyphenol on the oxidative stability of pecan oil. Food and Chemical Toxicology 119, pages 489-495.
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Gokhan Zengin, Ismail Senkardes, Adriano Mollica, Carene Marie Nancy Picot-Allain, Gizem Bulut, Ahmet Dogan & M. Fawzi Mahomoodally. (2018) New insights into the in vitro biological effects, in silico docking and chemical profile of clary sage – Salvia sclarea L.. Computational Biology and Chemistry 75, pages 111-119.
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Huafang Ding, Xiaqing Wu, Junhui Pan, Xing Hu, Deming Gong & Guowen Zhang. (2018) New Insights into the Inhibition Mechanism of Betulinic Acid on α-Glucosidase. Journal of Agricultural and Food Chemistry 66:27, pages 7065-7075.
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Luigi Menghini, Lidia Leporini, Giulia Vecchiotti, Marcello Locatelli, Simone Carradori, Claudio Ferrante, Gokhan Zengin, Lucia Recinella, Annalisa Chiavaroli, Sheila Leone, Luigi Brunetti & Giustino Orlando. (2018) Crocus sativus L. stigmas and byproducts: Qualitative fingerprint, antioxidant potentials and enzyme inhibitory activities. Food Research International 109, pages 91-98.
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Onur Bender, Eulogio J. Llorent-Martínez, Gokhan Zengin, Adriano Mollica, Ramazan Ceylan, Lucia Molina-García, Maria Luisa Fernández-de Córdova & Arzu Atalay. (2018) Integration of in vitro and in silico perspectives to explain chemical characterization, biological potential and anticancer effects of Hypericum salsugineum: A pharmacologically active source for functional drug formulations. PLOS ONE 13:6, pages e0197815.
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Adriano Mollica, Gokhan Zengin, Marcello Locatelli, Carene Marie Nancy Picot-Allain & Mohamad Fawzi Mahomoodally. (2018) Multidirectional investigations on different parts of Allium scorodoprasum L. subsp. rotundum (L.) Stearn: Phenolic components, in vitro biological, and in silico propensities. Food Research International 108, pages 641-649.
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Bulent Kirkan, Cengiz Sarikurkcu, Mahmut Copuroglu, Mustafa Cengiz & Bektas Tepe. (2018) Is it possible to use the stalks of Gossypium hirsitum L., an important by-product of cotton cultivation, as an alternative source of bioactive components?. European Food Research and Technology 244:6, pages 1065-1071.
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Andrei Mocan, Cadmiel Moldovan, Gökhan Zengin, Onur Bender, Marcello Locatelli, Mario Simirgiotis, Arzu Atalay, Dan Cristian Vodnar, Sascha Rohn & Gianina Crișan. (2018) UHPLC-QTOF-MS analysis of bioactive constituents from two Romanian Goji (Lycium barbarum L.) berries cultivars and their antioxidant, enzyme inhibitory, and real-time cytotoxicological evaluation. Food and Chemical Toxicology 115, pages 414-424.
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Gokhan Zengin, Gizem Bulut, Adriano Mollica, Carene Marie Nancy Picot-Allain & Mohamad Fawzi Mahomoodally. (2018) In vitro and in silico evaluation of Centaurea saligna (K.Koch) Wagenitz—An endemic folk medicinal plant. Computational Biology and Chemistry 73, pages 120-126.
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Mihai Babotă, Andrei Mocan, Laurian Vlase, Ovidiu Crișan, Irina Ielciu, Ana-Maria Gheldiu, Dan Vodnar, Gianina Crișan & Ramona Păltinean. (2018) Phytochemical Analysis, Antioxidant and Antimicrobial Activities of Helichrysum arenarium (L.) Moench. and Antennaria dioica (L.) Gaertn. Flowers. Molecules 23:2, pages 409.
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Hanqing Wang, Jiaoning Li, Weiwei Tao, Xia Zhang, Xiaojuan Gao, Jingjiao Yong, Jianjun Zhao, Liming Zhang, Yongzhou Li & Jin-ao Duan. (2018) Lycium ruthenicum studies: Molecular biology, Phytochemistry and pharmacology. Food Chemistry 240, pages 759-766.
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Andrei Mocan, Gokhan Zengin, Adriano Mollica, Ahmet Uysal, Erdogan Gunes, Gianina Crişan & Abdurrahman Aktumsek. (2018) Biological effects and chemical characterization of Iris schachtii Markgr. extracts: A new source of bioactive constituents. Food and Chemical Toxicology 112, pages 448-457.
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Eulogio J. Llorent-Martínez, Gokhan Zengin, Devina Lobine, Lucia Molina-García, Adriano Mollica & Mohamad Fawzi Mahomoodally. (2018) Phytochemical characterization, in vitro and in silico approaches for three Hypericum species . New Journal of Chemistry 42:7, pages 5204-5214.
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Sengul Uysal, Asli Ugurlu, Gokhan Zengin, Mehmet Cengiz Baloglu, Yasemin Celik Altunoglu, Adriano Mollica, Luisa Custodio, Nuno R. Neng, José M.F. Nogueira & M. Fawzi Mahomoodally. (2018) Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.. Food and Chemical Toxicology 111, pages 525-536.
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Gokhan Zengin, Hassan H. Abdallah, Ahmet Dogan, Adriano Mollica, Zaahira Aumeeruddy-Elalfi & Mohamad Fawzi Mahomoodally. (2018) Phenolic components and assessment of biological properties of Tchihatchewia isatidea Boiss. extracts: Docking and functional approaches for designing novel products. Food and Chemical Toxicology 111, pages 423-431.
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Satyajit D. Sarker & Lutfun Nahar. 2018. Computational Phytochemistry. Computational Phytochemistry 1 41 .
Annalisa Lopatriello, Rosario Previtera, Simona Pace, Markus Werner, Luigi Rubino, Oliver Werz, Orazio Taglialatela-Scafati & Martino Forino. (2017) NMR-based identification of the major bioactive molecules from an Italian cultivar of Lycium barbarum. Phytochemistry 144, pages 52-57.
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Ilhem Rjeibi, Anouar Feriani, Anouar Ben Saad, Sana Ncib, Jazia Sdayria, Issam Saidi, Sami Souid, Najla Hfaiedh & Mohamed Salah Allagui. (2017) Phytochemical characterization and bioactivity of Lycium europaeum: A focus on antioxidant, antinociceptive, hepatoprotective and nephroprotective effects. Biomedicine & Pharmacotherapy 95, pages 1441-1450.
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Michele Protti, Isacco Gualandi, Roberto Mandrioli, Sergio Zappoli, Domenica Tonelli & Laura Mercolini. (2017) Analytical profiling of selected antioxidants and total antioxidant capacity of goji ( Lycium spp.) berries. Journal of Pharmaceutical and Biomedical Analysis 143, pages 252-260.
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Catarina Guerreiro Pereira, Luísa Barreira, Nuno da Rosa Neng, José Manuel Florêncio Nogueira, Cátia Marques, Tamára F. Santos, João Varela & Luísa Custódio. (2017) Searching for new sources of innovative products for the food industry within halophyte aromatic plants: In vitro antioxidant activity and phenolic and mineral contents of infusions and decoctions of Crithmum maritimum L.. Food and Chemical Toxicology 107, pages 581-589.
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Maria João Rodrigues, Katkam N. Gangadhar, Gokhan Zengin, Adriano Mollica, João Varela, Luísa Barreira & Luísa Custódio. (2017) Juncaceae species as sources of innovative bioactive compounds for the food industry: In vitro antioxidant activity, neuroprotective properties and in silico studies. Food and Chemical Toxicology 107, pages 590-596.
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E.J. Llorent-Martínez, P. Ortega-Barrales, G. Zengin, A. Mocan, M.J. Simirgiotis, R. Ceylan, S. Uysal & A. Aktumsek. (2017) Evaluation of antioxidant potential, enzyme inhibition activity and phenolic profile of Lathyrus cicera and Lathyrus digitatus: Potential sources of bioactive compounds for the food industry. Food and Chemical Toxicology 107, pages 609-619.
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Marinella De Leo, Lorenzo Peruzzi, Carlotta Granchi, Tiziano Tuccinardi, Filippo Minutolo, Nunziatina De Tommasi & Alessandra Braca. (2017) Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase . Journal of Natural Products 80:7, pages 2077-2087.
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Javier Echeverría, Alejandro Urzúa, Loreto Sanhueza & Marcela Wilkens. (2017) Enhanced Antibacterial Activity of Ent-Labdane Derivatives of Salvic Acid (7α-Hydroxy-8(17)-ent-Labden-15-Oic Acid): Effect of Lipophilicity and the Hydrogen Bonding Role in Bacterial Membrane Interaction. Molecules 22:7, pages 1039.
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Gokhan Zengin, Adriano Mollica, Abdurrahman Aktumsek, Carene Marie Nancy Picot & Mohamad Fawzi Mahomoodally. (2017) In vitro and in silico insights of Cupressus sempervirens, Artemisia absinthium and Lippia triphylla: Bridging traditional knowledge and scientific validation. European Journal of Integrative Medicine 12, pages 135-141.
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Sengul Uysal, Gokhan Zengin, Marcello Locatelli, Mir B. Bahadori, Andrei Mocan, Giuseppe Bellagamba, Elisa De Luca, Adriano Mollica & Abdurrahman Aktumsek. (2017) Cytotoxic and Enzyme Inhibitory Potential of Two Potentilla species (P. speciosa L. and P. reptans Willd.) and Their Chemical Composition. Frontiers in Pharmacology 8.
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Eulogio J. Llorent-Martínez, Gokhan Zengin, María L. Fernández-de Córdova, Onur Bender, Arzu Atalay, Ramazan Ceylan, Adriano Mollica, Andrei Mocan, Sengul Uysal, Gokalp O. Guler & Abdurrahman Aktumsek. (2017) Traditionally Used Lathyrus Species: Phytochemical Composition, Antioxidant Activity, Enzyme Inhibitory Properties, Cytotoxic Effects, and in silico Studies of L. czeczottianus and L. nissolia. Frontiers in Pharmacology 8.
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Mayara Zagonel de Souza Zanchet, Geisson Marcos Nardi, Letícia de Oliveira Souza Bratti, Fabíola Branco Filippin-Monteiro & Claudriana Locatelli. (2017) Lycium barbarum Reduces Abdominal Fat and Improves Lipid Profile and Antioxidant Status in Patients with Metabolic Syndrome . Oxidative Medicine and Cellular Longevity 2017, pages 1-12.
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Gokhan Zengin, Abdurrahman Aktumsek, Ramazan Ceylan, Sengul Uysal, Andrei Mocan, Gokalp Ozmen Guler, M. Fawzi Mahomoodally, Jasmina Glamočlija, Ana Ćirić & Marina Soković. (2017) Shedding light on the biological and chemical fingerprints of three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia). Food & Function 8:3, pages 1152-1165.
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Milena Terzić, Tatjana Majkić, Ivana Beara, Gökhan Zengin, Uroš Miljić, Saša Đurović, Adriano Mollica & Marija Radojković. (2022) Elderberry (Sambucus Nigra L.) Wine as a Novel Potential Functional Food Product. SSRN Electronic Journal.
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Letícia Cristina Gonçalves, Maria Tereza Pamplona Silva, Fernanda Flores Navarro & Maria Aparecida Marin-Morales. (2022) Evaluation of the Genotoxic and Antigenotoxic Action of Goji Berry Extract. SSRN Electronic Journal.
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