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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 32, 2017 - Issue 1
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Research Article

Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B

Rita MeledduDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy;
,
Simona DistintoDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy;
,
Roberto CirilliDipartimento del Farmaco, Istituto Superiore di Sanità, Rome, Italy;
,
Stefano AlcaroDipartimento di Scienze della Salute, Università Magna Græcia di Catanzaro, Catanzaro, Italy;
,
Matilde YanezDepartamento de Farmacología and Instituto de Farmacia Industrial, Universidad de Santiago de Compostela, Campus Universitario Sur, Santiago de Compostela, Spain;
,
Maria Luisa SannaDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy;
,
Angela CoronaDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy;
,
Claudia MelisDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy;
,
Giulia BiancoDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy;
,
Peter MatyusDepartment of Organic Chemistry, Semmelweis University, Budapest, Hungary
,
Filippo CottigliaDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy;
&
Elias MaccioniDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy; Correspondence[email protected]
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Pages 264-270 | Received 04 Aug 2016, Accepted 05 Sep 2016, Published online: 18 Jan 2017

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Zhuo Kong, Demeng Sun, Yanmei Jiang & Yun Hu. (2020) Design, synthesis, and evaluation of 1, 4-benzodioxan-substituted chalcones as selective and reversible inhibitors of human monoamine oxidase B. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1513-1523.
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Articles from other publishers (11)

Pengbing Mi, Yan Tan, Shiying Ye, Jia-Jia Lang, You Lv, Jinhuan Jiang, Limei Chen, Jianxiong luo, Yuqing Lin, Zhonghua Yuan, Xing Zheng & Ying-Wu Lin. (2024) Discovery of C-3 isoxazole substituted thiochromone S,S-dioxide derivatives as potent and selective inhibitors for monoamine oxidase B (MAO-B). European Journal of Medicinal Chemistry 263, pages 115956.
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Vaishali M. Patil, Neeraj Masand, Vertika Gautam, Shikha Kaushik & Dee Wu. 2023. Deciphering Drug Targets for Alzheimer’s Disease. Deciphering Drug Targets for Alzheimer’s Disease 285 319 .
Pratibha Sharma, Manjinder Singh & Bijo Mathew. (2021) An Update of Synthetic Approaches and Structure‐Activity Relationships of Various Classes of Human MAO‐B Inhibitors. ChemistrySelect 6:7, pages 1404-1429.
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Su-Min Wu, Xiao-Yang Qiu, Shu-Juan Liu & Juan Sun. (2020) Single Heterocyclic Compounds as Monoamine Oxidase Inhibitors: From Past to Present. Mini-Reviews in Medicinal Chemistry 20:10, pages 908-920.
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Neetu Agrawal & Pradeep Mishra. (2019) Novel isoxazole derivatives as potential antiparkinson agents: synthesis, evaluation of monoamine oxidase inhibitory activity and docking studies. Medicinal Chemistry Research 28:9, pages 1488-1501.
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Rati Kailash Prasad Tripathi & Senthil Raja Ayyannan. (2019) Monoamine oxidase-B inhibitors as potential neurotherapeutic agents: An overview and update. Medicinal Research Reviews 39:5, pages 1603-1706.
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Neetu Agrawal & Pradeep Mishra. (2019) Synthesis, monoamine oxidase inhibitory activity and computational study of novel isoxazole derivatives as potential antiparkinson agents. Computational Biology and Chemistry 79, pages 63-72.
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Abha Sharma, Vidhu Pachauri & S. J. S. Flora. (2018) Advances in Multi-Functional Ligands and the Need for Metal-Related Pharmacology for the Management of Alzheimer Disease. Frontiers in Pharmacology 9.
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Pierre Koch, Andreas Brunschweiger, Vigneshwaran Namasivayam, Stefan Ullrich, Annalisa Maruca, Beatrice Lazzaretto, Petra Küppers, Sonja Hinz, Jörg Hockemeyer, Michael Wiese, Jag Heer, Stefano Alcaro, Katarzyna Kiec-Kononowicz & Christa E. Müller. (2018) Probing Substituents in the 1- and 3-Position: Tetrahydropyrazino-Annelated Water-Soluble Xanthine Derivatives as Multi-Target Drugs With Potent Adenosine Receptor Antagonistic Activity. Frontiers in Chemistry 6.
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Neetu Agrawal & Pradeep Mishra. (2018) The synthetic and therapeutic expedition of isoxazole and its analogs. Medicinal Chemistry Research 27:5, pages 1309-1344.
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Cinzia Sanna, Monica Scognamiglio, Antonio Fiorentino, Angela Corona, Vittoria Graziani, Alessia Caredda, Pierluigi Cortis, Mariofilippo Montisci, Elisa Rita Ceresola, Filippo Canducci, Ferruccio Poli, Enzo Tramontano & Francesca Esposito. (2018) Prenylated phloroglucinols from Hypericum scruglii, an endemic species of Sardinia (Italy), as new dual HIV-1 inhibitors effective on HIV-1 replication. PLOS ONE 13:3, pages e0195168.
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