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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 32, 2017 - Issue 1
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Research Paper

Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities

Sveva PellicciaDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Roma, Italy; View further author information
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Yu-Hsuan WuInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; ;Center of Infectious Disease and Signaling Research, College of Medicine, National Cheng Kung University, Tainan, Taiwan; View further author information
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Antonio ColucciaDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Roma, Italy; View further author information
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Giuseppe La ReginaDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Roma, Italy; View further author information
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Chin-Kai TsengInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; ;Center of Infectious Disease and Signaling Research, College of Medicine, National Cheng Kung University, Tainan, Taiwan; View further author information
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Valeria FamigliniDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Roma, Italy; View further author information
,
Domiziana MasciDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Roma, Italy; View further author information
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John HiscottIstituto Pasteur Italia – Fondazione Cenci Bolognetti, Roma, Italy; View further author information
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Jin-Ching LeeDepartment of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan; ;Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; ;Research Center for Natural Products and Drug Development, Kaohsiung Medical University, Kaohsiung, Taiwan; ;Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanCorrespondence[email protected]
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&
Romano SilvestriDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Roma, Italy; Correspondence[email protected]
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Pages 1091-1101 | Received 30 Apr 2017, Accepted 12 Jul 2017, Published online: 04 Aug 2017

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Miah Roney, A. K. M. Moyeenul Huq, Abdul Rashid Issahaku, Mahmoud E. S. Soliman, Md. Sanower Hossain, Abu Hasnat Mustafa, Md. Alimul Islam, Amit Dubey, Aisha Tufail, Mohd Fadhlizil Fasihi Mohd Aluwi & Saiful Nizam Tajuddin. (2023) Pharmacophore-based virtual screening and in-silico study of natural products as potential DENV-2 RdRp inhibitors. Journal of Biomolecular Structure and Dynamics 41:21, pages 12186-12203.
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Wei-Chun Chen, Chin-Kai Tseng, Chun-Kuang Lin, Shen-Nien Wang, Wen-Hung Wang, Shih-Hsien Hsu, Yu-Hsuan Wu, Ling-Chien Hung, Yen-Hsu Chen & Jin-Ching Lee. (2018) Lucidone suppresses dengue viral replication through the induction of heme oxygenase-1. Virulence 9:1, pages 588-603.
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Naoko Uno & Ted M. Ross. (2018) Dengue virus and the host innate immune response. Emerging Microbes & Infections 7:1, pages 1-11.
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Articles from other publishers (25)

Noor ul Amin Mohsin, Muhammad Irfan & Shaista Qamar. (2023) Current Advancements for New Drug Discovery Against Dengue Virus: A Review (2015 – 2020). Pharmaceutical Chemistry Journal 57:6, pages 932-951.
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S. H. Rashmi, K. Sai Disha, N. Sudheesh, Joseph Karunakaran, Alex Joseph, Anitha Jagadesh & P. P. Mudgal. (2023) Repurposing of approved antivirals against dengue virus serotypes: an in silico and in vitro mechanistic study. Molecular Diversity.
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Bibek Raj Bhattarai, Bikash Adhikari, Saroj Basnet, Asmita Shrestha, Rishab Marahatha, Babita Aryal, Binod Rayamajhee, Pramod Poudel & Niranjan Parajuli. (2022) In Silico Elucidation of Potent Inhibitors from Natural Products for Nonstructural Proteins of Dengue Virus. Journal of Chemistry 2022, pages 1-12.
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Jianhai Yu, Xujuan Li, Dongrui Zhou, Xuling Liu, Xiaoen He, Sheng-He Huang, Qinghua Wu, Li Zhu, Linzhong Yu, Jinxiu Yao, Bao Zhang & Wei Zhao. (2022) Vimentin Inhibits Dengue Virus Type 2 Invasion of the Blood-Brain Barrier. Frontiers in Cellular and Infection Microbiology 12.
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Shelly Pathania, Ravindra K. Rawal & Pankaj Kumar Singh. (2022) RdRp (RNA-dependent RNA polymerase): A key target providing anti-virals for the management of various viral diseases. Journal of Molecular Structure 1250, pages 131756.
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Sheikh Murtuja, Deepak Shilkar, Biswatrish Sarkar, Barij Nayan Sinha & Venkatesan Jayaprakash. (2021) A short survey of dengue protease inhibitor development in the past 6 years (2015–2020) with an emphasis on similarities between DENV and SARS-CoV-2 proteases. Bioorganic & Medicinal Chemistry 49, pages 116415.
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Sheikh Murtuja, Deepak Shilkar, Biswatrish Sarkar, Barij Nayan Sinha & Venkatesan Jayaprakash. 2021. Human Viruses: Diseases, Treatments and Vaccines. Human Viruses: Diseases, Treatments and Vaccines 93 120 .
Atukuri Dorababu. (2020) Indole – a promising pharmacophore in recent antiviral drug discovery. RSC Medicinal Chemistry 11:12, pages 1335-1353.
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Venkatanarayana C. Maddipati, Lovika Mittal, Manohar Mantipally, Shailendra Asthana, Sankar Bhattacharyya & Rambabu Gundla. (2020) A Review on the Progress and Prospects of Dengue Drug Discovery Targeting NS5 RNA- Dependent RNA Polymerase. Current Pharmaceutical Design 26:35, pages 4386-4409.
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Antonio Coluccia, Michela Puxeddu, Marianna Nalli, Chih-Ku Wei, Yu-Hsuan Wu, Eloise Mastrangelo, Tasneem Elamin, Delia Tarantino, Joachim Jakob Bugert, Benno Schreiner, Juliane Nolte, Frank Schwarze, Giuseppe La Regina, Jin-Ching Lee & Romano Silvestri. (2020) Discovery of Zika Virus NS2B/NS3 Inhibitors That Prevent Mice from Life-Threatening Infection and Brain Damage. ACS Medicinal Chemistry Letters 11:10, pages 1869-1874.
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Anusuya Shanmugam, Chandrasekaran Ramakrishnan, Devadasan Velmurugan & M. Michael Gromiha. (2020) Identification of Potential Inhibitors for Targets Involved in Dengue Fever. Current Topics in Medicinal Chemistry 20:19, pages 1742-1760.
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Adib Afandi Abdullah, Yean Kee Lee, Sek Peng Chin, See Khai Lim, Vannajan Sanghiran Lee, Rozana Othman, Shatrah Othman, Noorsaadah Abdul Rahman, Rohana Yusof & Choon Han Heh. (2020) Discovery of Dengue Virus Inhibitors. Current Medicinal Chemistry 27:30, pages 4945-5036.
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Yihong Wan, Shengen Wu, Sichao Zheng, En Liang, Shuwen Liu, Xingang Yao & Qiuhua Zhu. (2020) A series of octahydroquinazoline-5-ones as novel inhibitors against dengue virus. European Journal of Medicinal Chemistry 200, pages 112318.
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Rudra Narayan Dash, Alok Kumar Moharana & Bharat Bhusan Subudhi. (2020) Sulfonamides: Antiviral Strategy for Neglected Tropical Disease Virus. Current Organic Chemistry 24:9, pages 1018-1041.
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Syeda Shamila Hamdani, Bilal Ahmad Khan, Shahid Hameed, Farwa Batool, Hafiza Nosheen Saleem, Ehsan Ullah Mughal & Muhammad Saeed. (2020) Synthesis and evaluation of novel S-benzyl- and S-alkylphthalimide- oxadiazole -benzenesulfonamide hybrids as inhibitors of dengue virus protease. Bioorganic Chemistry 96, pages 103567.
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Sveva Pelliccia, Antonella Ilenia Alfano, Paolo Luciano, Ettore Novellino, Alberto Massarotti, Gian Cesare Tron, Davide Ravelli & Mariateresa Giustiniano. (2019) Photocatalytic Isocyanide-Based Multicomponent Domino Cascade toward the Stereoselective Formation of Iminofurans. The Journal of Organic Chemistry 85:4, pages 1981-1990.
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Amudhan Murugesan & Mythreyee Manoharan. 2020. Emerging and Reemerging Viral Pathogens. Emerging and Reemerging Viral Pathogens 281 359 .
Satish N. Dighe, O'mezie Ekwudu, Kamal Dua, Dinesh Kumar Chellappan, Peter L. Katavic & Trudi A. Collet. (2019) Recent update on anti-dengue drug discovery. European Journal of Medicinal Chemistry 176, pages 431-455.
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Jitra Limthongkul, Nithipong Mapratiep, Suttikarn Apichirapokey, Ampa Suksatu, Panuwat Midoeng & Sukathida Ubol. (2019) Insect anionic septapeptides suppress DENV replication by activating antiviral cytokines and miRNAs in primary human monocytes. Antiviral Research 168, pages 1-8.
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Kerstin Ruoff, Turgay Kilic, Jessica Devant, Anna Koromyslova, Alessa Ringel, Alexander Hempelmann, Celina Geiss, Juliane Graf, Michelle Haas, Imme Roggenbach & Grant Hansman. (2019) Structural Basis of Nanobodies Targeting the Prototype Norovirus. Journal of Virology 93:6.
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Siew Pheng Lim. (2019) Dengue drug discovery: Progress, challenges and outlook. Antiviral Research 163, pages 156-178.
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Vaishali M. Patil, Krishnan Balasubramanian & Neeraj Masand. 2019. Viral Polymerases. Viral Polymerases 387 428 .
Ankit Ganeshpurkar, Gopichand Gutti & Sushil Kumar Singh. 2019. Viral Polymerases. Viral Polymerases 1 42 .
Michaela Rumlová & Tomáš Ruml. (2018) In vitro methods for testing antiviral drugs. Biotechnology Advances 36:3, pages 557-576.
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