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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 33, 2018 - Issue 1
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Research Paper

Synthesis and antitumor activity of novel 2, 3-didithiocarbamate substituted naphthoquinones as inhibitors of pyruvate kinase M2 isoform

Xianling NingInstitute of Systems Biomedicine, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China; ;Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China; View further author information
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Hailong QiInstitute of Systems Biomedicine, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China; ;Peking-Tsinghua Center for Life Sciences, Peking University Health Science Center, Beijing, China; View further author information
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Ridong LiInstitute of Systems Biomedicine, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China; ;Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China; View further author information
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Yan JinInstitute of Systems Biomedicine, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China; ;Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, ChinaView further author information
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Michael A. McNuttInstitute of Systems Biomedicine, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China; ;Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, ChinaView further author information
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Yuxin YinInstitute of Systems Biomedicine, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, China; ;Peking-Tsinghua Center for Life Sciences, Peking University Health Science Center, Beijing, China; ;Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, ChinaCorrespondence[email protected]
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Pages 126-129 | Received 09 Sep 2017, Accepted 09 Nov 2017, Published online: 29 Nov 2017

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Zhirui Zeng, Jinzhi Lan, Shan Lei, Yushi Yang, Zhiwei He, Yan Xue & Tengxiang Chen. (2020) Simultaneous Inhibition of Ornithine Decarboxylase 1 and Pyruvate Kinase M2 Exerts Synergistic Effects Against Hepatocellular Carcinoma Cells. OncoTargets and Therapy 13, pages 11697-11709.
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Articles from other publishers (20)

Lufeng Chen, Dongming Zhao, Xiangling Ren, Jun Ren, Xianwei Meng, Changhui Fu & Xianfeng Li. (2023) Shikonin-Loaded Hollow Fe-MOF Nanoparticles for Enhanced Microwave Thermal Therapy. ACS Biomaterials Science & Engineering 9:9, pages 5405-5417.
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Pavels Dimitrijevs, Marina Makrecka-Kuka, Agnieszka Bogucka, Marko Hyvönen, Teodors Pantelejevs & Pavel Arsenyan. (2023) Development of isoselenazolium chlorides as selective pyruvate kinase isoform M2 inhibitors. European Journal of Medicinal Chemistry 257, pages 115504.
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Ludovico Pipitò, Thomas Arron Illingworth & Giuseppe Deganutti. (2023) Targeting hPKM2 in cancer: A bio isosteric approach for ligand design. Computers in Biology and Medicine 158, pages 106852.
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Chunxue Jiang, Xiaodi Zhao, Taejoo Jeong, Ju Young Kang, Jae Hyeon Park, In Su Kim & Hyung Sik Kim. (2022) Novel Specific Pyruvate Kinase M2 Inhibitor, Compound 3h, Induces Apoptosis and Autophagy through Suppressing Akt/mTOR Signaling Pathway in LNCaP Cells. Cancers 15:1, pages 265.
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Sahil Arora, Gaurav Joshi, Anuhar Chaturvedi, Michael Heuser, Santoshkumar Patil & Raj Kumar. (2021) A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2. Journal of Medicinal Chemistry 65:2, pages 1171-1205.
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Xueyan Sun, Yijiao Peng, Jingduo Zhao, Zhizhong Xie, Xiaoyong Lei & Guotao Tang. (2021) Discovery and development of tumor glycolysis rate-limiting enzyme inhibitors. Bioorganic Chemistry 112, pages 104891.
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Susi Zhu, Yeye Guo, Xu Zhang, Hong Liu, Mingzhu Yin, Xiang Chen & Cong Peng. (2021) Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics. Cancer Letters 503, pages 240-248.
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Dexter L. Puckett, Mohammed Alquraishi, Winyoo Chowanadisai & Ahmed Bettaieb. (2021) The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs. International Journal of Molecular Sciences 22:3, pages 1171.
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Ranyue Ren, Jiachao Guo, Jia Shi, Yong Tian, Mengwei Li & Hao Kang. (2020) PKM2 regulates angiogenesis of VR‐EPCs through modulating glycolysis, mitochondrial fission, and fusion. Journal of Cellular Physiology 235:9, pages 6204-6217.
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Kulsoom Zahra, Tulika Dey, Ashish, Surendra Pratap Mishra & Uma Pandey. (2020) Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis. Frontiers in Oncology 10.
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Sara N. Garcia, Rita C. Guedes & M. Matilde Marques. (2020) Unlocking the Potential of HK2 in Cancer Metabolism and Therapeutics. Current Medicinal Chemistry 26:41, pages 7285-7322.
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Qiongli Su, Shengping Luo, Qiuhong Tan, Jun Deng, Sichun Zhou, Mei Peng, Ting Tao & Xiaoping Yang. (2019) The role of pyruvate kinase M2 in anticancer therapeutic treatments (Review). Oncology Letters.
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Joelle C. Boulos, Muhammad Rahama, Mohamed-Elamir F. Hegazy & Thomas Efferth. (2019) Shikonin derivatives for cancer prevention and therapy. Cancer Letters 459, pages 248-267.
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Sajid Amin, Peng Yang & Zhuoyu Li. (2019) Pyruvate kinase M2: A multifarious enzyme in non-canonical localization to promote cancer progression. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1871:2, pages 331-341.
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Robert A. Harris & Aron W. Fenton. (2019) A critical review of the role of M2PYK in the Warburg effect. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1871:2, pages 225-239.
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Claudia Di Carlo, Jessica Brandi & Daniela Cecconi. (2018) Pancreatic cancer stem cells: Perspectives on potential therapeutic approaches of pancreatic ductal adenocarcinoma. World Journal of Stem Cells 10:11, pages 172-182.
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Bin Zhao, Sijia Fan, Zhijin Fan, Haixia Wang, Nailou Zhang, Xiaofeng Guo, Dongyan Yang, Qifan Wu, Bin Yu & Shuang Zhou. (2018) Discovery of Pyruvate Kinase as a Novel Target of New Fungicide Candidate 3-(4-Methyl-1,2,3-thiadiazolyl)-6-trichloromethyl-[1,2,4]-triazolo-[3,4- b ][1,3,4]-thiadizole . Journal of Agricultural and Food Chemistry 66:46, pages 12439-12452.
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Amruta Nayak, Arvinder Kapur, Lisa Barroilhet & Manish Patankar. (2018) Oxidative Phosphorylation: A Target for Novel Therapeutic Strategies Against Ovarian Cancer. Cancers 10:9, pages 337.
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Atsushi Masamune, Shin Hamada, Naoki Yoshida, Tatsuhide Nabeshima & Tooru Shimosegawa. (2018) Pyruvate Kinase Isozyme M2 Plays a Critical Role in the Interactions Between Pancreatic Stellate Cells and Cancer Cells. Digestive Diseases and Sciences 63:7, pages 1868-1877.
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Xianling Ning, Yunqiao Li, Hailong Qi, Ridong Li, Yan Jin, Junyi Liu & Yuxin Yin. (2018) Anti-cancer effect of a novel 2,3-didithiocarbamate-substituted naphthoquinone as a tumor metabolic suppressor in vitro and in vivo . MedChemComm 9:4, pages 632-638.
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