Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 33, 2018 - Issue 1
Submit an article Journal homepage
1,819
Views
15
CrossRef citations to date
0
Altmetric
Research Paper

Design and synthesis of novel oridonin analogues as potent anticancer agents

Qing-Kun ShenKey Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, College of Pharmacy, Yanbian University, Yanji, China; View further author information
,
Zheng-Ai ChenDepartment of Pharmacology, Medical School of Yanbian University, Yanji, China; View further author information
,
Hong-Jian ZhangKey Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, College of Pharmacy, Yanbian University, Yanji, China; View further author information
,
Jia-Li LiKey Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, College of Pharmacy, Yanbian University, Yanji, China; View further author information
,
Chuan-Feng LiuKey Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, College of Pharmacy, Yanbian University, Yanji, China; View further author information
,
Guo-Hua GongMedicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao, China; ;Inner Mongolia Autonomous Region Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao, ChinaCorrespondence[email protected]
View further author information
&
Zhe-Shan QuanKey Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, College of Pharmacy, Yanbian University, Yanji, China; Correspondence[email protected]
View further author information
 show all
Pages 324-333 | Received 22 Oct 2017, Accepted 13 Dec 2017, Published online: 05 Jan 2018

Citations (15)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Chen-Liang Zhao, Chi-Yuan Zhang, Xiao-Min Yang, Ka Hei Lam, Yi-Xuan Xia, Yin-Xiao Du, Lu-Tai Pan & Hong-Jie Zhang. Design and synthesis of oridonin derivatives as cytotoxic agents. Natural Product Research 0:0, pages 1-9.
Read now

Articles from other publishers (14)

Jialin Yao, Lu Liu, Qingxiang Sun & Xiaofei Shen. (2023) Direct cellular targets and anticancer mechanisms of the natural product oridonin. MedComm – Future Medicine 2:1.
Crossref
Pedro J. M. Sobral, André T. S. Vicente & Jorge A. R. Salvador. (2023) Recent advances in oridonin derivatives with anticancer activity. Frontiers in Chemistry 11.
Crossref
Hao Deng, Qian Xu, Hong-Yan Guo, Xing Huang, Fener Chen, Lili Jin, Zhe-Shan Quan & Qing-Kun Shen. (2023) Application of cinnamic acid in the structural modification of natural products: A review. Phytochemistry 206, pages 113532.
Crossref
T. Arokia Femina, V. Barghavi, K. Archana, N.G. Swethaa & Ravi Maddaly. (2023) Non-uniformity in in vitro drug-induced cytotoxicity as evidenced by differences in IC50 values – implications and way forward. Journal of Pharmacological and Toxicological Methods 119, pages 107238.
Crossref
Junkai Liu, Shaowen Xie, Xiao Shao, Songtao Xue, Pian Du, Hongyu Wu, Shengtao Xu, Zhe-Sheng Chen, Dong-Hua Yang, Jinyi Xu & Hong Yao. (2022) Identification of new potent anticancer derivatives through simplifying the core structure and modification on their 14- hydroxyl group from oridonin. European Journal of Medicinal Chemistry 231, pages 114155.
Crossref
Myong Hak Ri, Juan Ma & Xuejun Jin. (2021) Development of natural products for anti-PD-1/PD-L1 immunotherapy against cancer. Journal of Ethnopharmacology 281, pages 114370.
Crossref
Yong-Feng Guan, Xiu-Juan Liu, Xiao-Jing Pang, Wen-Bo Liu, Guang -Xi Yu, Yin -Ru Li, Yan-Bing Zhang, Jian Song & Sai-Yang Zhang. (2021) Recent progress of oridonin and its derivatives for cancer therapy and drug resistance. Medicinal Chemistry Research 30:10, pages 1795-1821.
Crossref
Xi Liu, Jimin Xu, Jia Zhou & Qiang Shen. (2021) Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance. Genes & Diseases 8:4, pages 448-462.
Crossref
Xu Hu, Yan Wang, Xiang Gao, Shengtao Xu, Linghe Zang, Yan Xiao, Zhanlin Li, Huiming Hua, Jinyi Xu & Dahong Li. (2020) Recent Progress of Oridonin and Its Derivatives for the Treatment of Acute Myelogenous Leukemia. Mini-Reviews in Medicinal Chemistry 20:6, pages 483-497.
Crossref
Yani Lin, Miaomiao Yu & Tingjun Fan. (2020) Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells. Toxicology Letters 320, pages 9-18.
Crossref
Emma K Davison & Margaret A Brimble. (2019) Natural product derived privileged scaffolds in drug discovery. Current Opinion in Chemical Biology 52, pages 1-8.
Crossref
Huahong Yang, Yun Gao, Xiaoye Fan, Xingkai Liu, Liping Peng & Xinxin Ci. (2019) Oridonin Sensitizes Cisplatin-Induced Apoptosis via AMPK/Akt/mTOR-Dependent Autophagosome Accumulation in A549 Cells. Frontiers in Oncology 9.
Crossref
Qing-Kun Shen, Hao Deng, Shi-Ben Wang, Yu-Shun Tian & Zhe-Shan Quan. (2019) Synthesis, and evaluation of in vitro and in vivo anticancer activity of 14-substituted oridonin analogs: A novel and potent cell cycle arrest and apoptosis inducer through the p53-MDM2 pathway. European Journal of Medicinal Chemistry 173, pages 15-31.
Crossref
Yuan Qu, Hui-Ying Liu, Xiao-Xi Guo, Yan Luo, Cheng-Xiao Wang, Jiang-Hua He, Tian-Rui Xu, Ye Yang & Xiu-Ming Cui. (2018) Converting ginsenosides from stems and leaves of Panax notoginseng by microwave processing and improving their anticoagulant and anticancer activities . RSC Advances 8:70, pages 40471-40482.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.