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Research Paper

Molecular modelling insights into a physiologically favourable approach to eicosanoid biosynthesis inhibition through novel thieno[2,3-b]pyridine derivatives

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Pages 755-767 | Received 12 Feb 2018, Accepted 21 Mar 2018, Published online: 13 Apr 2018

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Read on this site (3)

Mohamed S. Mohamed Ahmed, Ahmed M. Abdelfattah & Ahmed A. M. Ahmed. (2023) Synthesis of novel benzo[6,7]cyclohepta[1,2-b]thieno[3,2-e]pyridines and their bis-analogues linked to different spacers: Approach to a new ring system. Synthetic Communications 53:20, pages 1701-1712.
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Ahmed E. M. Mekky, Sherif M. H. Sanad, Ahmed Y. Said & Mohamed A. A. Elneairy. (2020) Synthesis, cytotoxicity, in-vitro antibacterial screening and in-silico study of novel thieno[2,3-b]pyridines as potential pim-1 inhibitors. Synthetic Communications 50:15, pages 2376-2389.
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Mohammad Mahboob Alam, Nawaf I. Alsenani, Antar A. Abdelhamid, Abrar Ahmad, Othman A. Baothman, Salman A. Hosawi, Hisham Altayeb, Mohammad Shahid Nadeem, Varish Ahmad, Syed Nazreen & Ahmed A. Elhenawy. (2023) New paracetamol hybrids as anticancer and COX‐2 inhibitors: Synthesis, biological evaluation and docking studies. Archiv der Pharmazie.
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Sherif M.H. Sanad & Ahmed E.M. Mekky. (2023) New bis(thieno[2,3- b ]pyridine) hybrids linked to arene units as potential bacterial biofilm and MRSA inhibitors . Canadian Journal of Chemistry 101:8, pages 538-547.
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Le Du, Shuaishuai Du, Jiaming Li & Hongwei Wang. (2022) Design, synthesis, and biological evaluation of dual-target COX-2/5-LOX inhibitors for the treatment of inflammation. Medicinal Chemistry Research 32:2, pages 218-238.
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Sherif M. H. Sanad & Ahmed E. M. Mekky. (2022) Ultrasound‐Mediated Synthesis of New (Piperazine‐Chromene)‐Linked Bis(thieno[2,3‐ b ]pyridine) Hybrids as Potential Anti‐acetylcholinesterase . ChemistrySelect 7:41.
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Ahmed A. M. Ahmed, Ahmed E. M. Mekky & Sherif M. H. Sanad. (2022) New bis(pyrazolo[3,4-b]pyridines) and bis(thieno[2,3-b]pyridines) as potential acetylcholinesterase inhibitors: synthesis, in vitro and SwissADME prediction study. Journal of the Iranian Chemical Society 19:11, pages 4457-4471.
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Pavlo V. Zadorozhnii, Vadym V. Kiselev & Aleksandr V. Kharchenko. 2022. Comprehensive Heterocyclic Chemistry IV. Comprehensive Heterocyclic Chemistry IV 456 506 .
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Sherif M. H. Sanad & Ahmed E. M. Mekky. (2020) Synthesis, cytotoxicity and in vitro antibacterial screening of novel hydrazones bearing thienopyridine moiety as potent COX-2 inhibitors. Journal of the Iranian Chemical Society 17:12, pages 3299-3315.
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Ahmed H. Abdelazeem, Asmaa G. Safi El-Din, Maha M. Abdel-Fattah, Noha H. Amin, Samir M. El-Moghazy & Mohammed T. El-Saadi. (2020) Discovery of novel urea-diarylpyrazole hybrids as dual COX-2/sEH inhibitors with improved anti-inflammatory activity and highly reduced cardiovascular risks. European Journal of Medicinal Chemistry 205, pages 112662.
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Francisco das Chagas Pereira de Andrade & Anderson Nogueira Mendes. (2020) Computational analysis of eugenol inhibitory activity in lipoxygenase and cyclooxygenase pathways. Scientific Reports 10:1.
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Sherif M. H. Sanad & Ahmed E. M. Mekky. (2020) Piperazine‐mediated tandem synthesis of bis(thieno[2,3‐ b ]pyridines): Versatile precursors for related fused [1,2,4]triazolo[4,3‐ a ]pyrimidines . Journal of Heterocyclic Chemistry 57:8, pages 3142-3152.
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Sherif M. H. Sanad & Ahmed E. M. Mekky. (2020) Novel Nicotinonitriles and Thieno[2,3‐ b ]pyridines as Potent Biofilm and COX‐2 Inhibitors: Synthesis, In Vitro and In Silico Studies . ChemistrySelect 5:28, pages 8494-8503.
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Yuanzheng Huang, Bin Zhang, Jiaming Li, Huicai Liu, Yanchun Zhang, Zhang Yang & Wandong Liu. (2019) Design, synthesis, biological evaluation and docking study of novel indole-2-amide as anti-inflammatory agents with dual inhibition of COX and 5-LOX. European Journal of Medicinal Chemistry 180, pages 41-50.
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