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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 33, 2018 - Issue 1
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Design, synthesis, and screening of ortho-amino thiophene carboxamide derivatives on hepatocellular carcinomaas VEGFR-2Inhibitors

Mohammed K. AbdElhameidPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt;
,
Madlen B. LabibDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt;
,
Ahmed T. NegmeldinPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt; ;Department of Pharmaceutical Sciences College of Pharmacy, Gulf Medical University, Gulf Medical University, Ajman, UAE; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-3399-3435
ORCID Icon,
Muhammad Al-ShorbagyPharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt; ;Pharmacology and Toxicology Department, School of Pharmacy, NewGiza University, Egypt,
&
Manal R. MohammedDepartment of Radiation Biology, National Center for Radiation Research and Technology, Cairo, Egypt
Pages 1472-1493 | Received 20 Mar 2018, Accepted 16 Jul 2018, Published online: 07 Sep 2018

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Articles from other publishers (23)

Eman K. A. Abdelall, Heba A. H. Elshemy, Madlen B. Labib & Fatma E. A. Mohamed. (2023) Design, synthesis of novel chromene‐based scaffolds targeting hepatocellular carcinoma: Cell cycle arrest, cytotoxic effect against resistant cancer cells, apoptosis induction, and c‐Src inhibition. Drug Development Research.
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Lauro Figueroa-Valverde, Francisco Díaz-Cedillo, Marcela Rosas-Nexticapa, Magdalena Alvarez-Ramirez, Maria Virginia Mateu-Armad, Maria López-Ramos & Tomas López-Gutierrez. (2023) Interaction of Some Amino-Nitrile Derivatives with Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Using a Theoretical Model. Drug Research 73:06, pages 355-364.
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Bilel Bouzayani, Manel Elakermi, Monji Ben Mosbah, Youness Moussaoui, Ghayth Rigane & Ridha Ben Salem. (2022) Synthesis and Antioxidant Assessment of some Derived Compounds from 2-Amino-3-Cyanothiophene. Chemistry Africa 6:3, pages 1201-1207.
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Ranza Elrayess, Mohamed S. Elgawish, Mohamed S. Nafie, Nagat Ghareb & Asmaa S. A. Yassen. (2023) 2‐Phenylquinazolin‐4(3 H )‐one scaffold as newly designed, synthesized VEGFR‐2 allosteric inhibitors with potent cytotoxicity through apoptosis . Archiv der Pharmazie 356:6.
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Vishakha S., Kumari Kajal, Sitanshu Mondal, Simranpreet K. Wahan, Balak Das Kurmi, Ghanshyam Das Gupta & Preeti Patel. (2023) Novel VEGFR‐2 Kinase Inhibitors as Anticancer Agents: A Review Focusing on SAR and Molecular Docking Studies (2016–2021). Chemistry & Biodiversity 20:2.
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Alex Ketzer, Érica G. Oliveira, Sarah F. Coelho, Yuri G. Kappenberg, Felipe S. Stefanello, Nilo Zanatta, Marcos A.P. Martins, Clarissa P. Frizzo & Helio G. Bonacorso. (2022) Bicyclic thiaspiro[4.n]alkanones: Investigating their total stereochemistry achieved by the catalyst-free sulfa-Michael reaction. Journal of Molecular Structure 1267, pages 133617.
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Mohamed A. Ismail, Ghada A. Abdelwahab, Wafaa S. Hamama, Ehab Abdel‐Latif, Fardous F. El‐Senduny & Wael M. El‐Sayed. (2022) Synthesis of new thienylnicotinamidines: Proapoptotic profile and cell cycle arrest of HepG2 cells. Archiv der Pharmazie 355:9, pages 2100385.
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Sobhi Gomha, Sayed Riyadh, Bader Huwaimel, Mohie Zayed & Magda Abdellattif. (2022) Synthesis, Molecular Docking Study, and Cytotoxic Activity against MCF Cells of New Thiazole–Thiophene Scaffolds. Molecules 27:14, pages 4639.
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Islam Zaki, Reham E. Masoud, Mohamed M.S. Hamoud, Ola A. Abu Ali, Matokah Abualnaja, Eman Fayad, Ali H. Abu Almaaty & Lamis K. Elnaghia. (2022) Design, synthesis and cytotoxicity screening of new synthesized pyrimidine-5-carbonitrile derivatives showing marked apoptotic effect. Journal of Molecular Structure 1259, pages 132749.
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Eman K.A. Abdelall, Heba A. H. Elshemy, Madlen B. Labib & Fatma E. A. Mohamed. (2022) Characterization of novel heterocyclic compounds based on 4-aryl-4H-chromene scaffold as anticancer agents: Design, synthesis, antiprofilerative activity against resistant cancer cells, dual β-tubulin/c-Src inhibition, cell cycle arrest and apoptosis induction. Bioorganic Chemistry 120, pages 105591.
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Osama M. Soltan, Mai E. Shoman, Salah A. Abdel-Aziz, Atsushi Narumi, Hiroyuki Konno & Mohamed Abdel-Aziz. (2021) Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy. European Journal of Medicinal Chemistry 225, pages 113768.
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Sahar M. Abou-Seri, Amal A.M. Eissa, Mohamed G.M. Behery & Farghaly A. Omar. (2021) Synthesis, in vitro anticancer activity and in silico studies of certain isoxazole-based carboxamides, ureates, and hydrazones as potential inhibitors of VEGFR2. Bioorganic Chemistry 116, pages 105334.
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Bing Yang, Jiahua Zhou, Fa Wang, Xiao-Wei Hu & Yujun Shi. (2021) Pyrazoline derivatives as tubulin polymerization inhibitors with one hit for Vascular Endothelial Growth Factor Receptor 2 inhibition. Bioorganic Chemistry 114, pages 105134.
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Naglaa M. Ahmed, Mahmoud M. Youns, Moustafa K. Soltan & Ahmed M. Said. (2021) Design, Synthesis, Molecular Modeling and Antitumor Evaluation of Novel Indolyl-Pyrimidine Derivatives with EGFR Inhibitory Activity. Molecules 26:7, pages 1838.
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Neha V. Bhilare, Pratibha B. Auti, Vinayak S. Marulkar & Vilas J. Pise. (2021) Diverse Thiophenes as Scaffolds in Anti-cancer Drug Development: A Concise Review. Mini-Reviews in Medicinal Chemistry 21:2, pages 217-232.
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Islam Zaki & Amal M. Imam. (2020) Design, Synthesis, and Cytotoxic Screening of New Quinoline Derivatives over MCF-7 Breast Cancer Cell Line. Russian Journal of Bioorganic Chemistry 46:6, pages 1099-1109.
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Fernanda P. Pauli, Juliana R. Martins, Thaysa Paschoalin, Marisa Ionta, Maria Leticia C. Barbosa & Eliezer J. Barreiro. (2020) Novel VEGFR‐2 inhibitors with an N ‐acylhydrazone scaffold . Archiv der Pharmazie 353:11, pages 2000130.
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Islam Zaki, Heba M. M. Ramadan, El‐Sherbiny H. El‐Sayed & Mohamed Abd El‐Moneim. (2020) Design, synthesis, and cytotoxicity screening of new synthesized imidazolidine‐2‐thiones as VEGFR‐2 enzyme inhibitors. Archiv der Pharmazie 353:11, pages 2000121.
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Archna, Shelly Pathania & Pooja A Chawla. (2020) Thiophene-based derivatives as anticancer agents: An overview on decade’s work. Bioorganic Chemistry 101, pages 104026.
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Mohammed K. Abdelhameid, Islam Zaki, Manal R. Mohammed & Khaled O. Mohamed. (2020) Design, synthesis, and cytotoxic screening of novel azole derivatives on hepatocellular carcinoma (HepG2 Cells). Bioorganic Chemistry 101, pages 103995.
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