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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 34, 2019 - Issue 1
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Research Paper

Computational screening of chalcones acting against topoisomerase IIα and their cytotoxicity towards cancer cell lines

Kanyani SangpheakFaculty of Science, Program in Biotechnology, Chulalongkorn University, Bangkok, Thailand; View further author information
,
Monika MuellerDepartment of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Vienna, Austria; View further author information
,
Nitchakan DaraiFaculty of Science, Program in Biotechnology, Chulalongkorn University, Bangkok, Thailand; View further author information
,
Peter WolschannDepartment of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Vienna, Austria; ;Institute of Theoretical Chemistry, University of Vienna, Vienna, Austria; View further author information
,
Chonticha SuwattanasophonDepartment of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Vienna, Austria; View further author information
,
Ritbey RugaFaculty of Science, Center of Excellence in Natural Products Chemistry, Department of Chemistry, Chulalongkorn University, Bangkok, Thailand; View further author information
,
Warinthon ChavasiriFaculty of Science, Center of Excellence in Natural Products Chemistry, Department of Chemistry, Chulalongkorn University, Bangkok, Thailand; View further author information
,
Supaporn SeetahaFaculty of Science, Department of Biochemistry, Kasetsart University, Bangkok, Thailand; View further author information
,
Kiattawee ChoowongkomonFaculty of Science, Department of Biochemistry, Kasetsart University, Bangkok, Thailand; View further author information
,
Nawee KungwanFaculty of Science, Department of Chemistry, Chiang Mai University, ChiangMai, Thailand; ;Center of Excellence in Materials Science and Technology, Chiang Mai University, ChiangMai, Thailand; View further author information
,
Chompoonut RungnimNanoscale Simulation Laboratory, National Nanotechnology Center, National Science and Technology Development Agency, Pathum Thani, Thailand; View further author information
&
Thanyada RungrotmongkolFaculty of Science, Biocatalyst and Environmental Biotechnology Research Unit, Department of Biochemistry, Chulalongkorn University, Bangkok, Thailand; ;Faculty of Science, Ph.D. Program in Bioinformatics and Computational Biology, Chulalongkorn University, Bangkok, ThailandCorrespondence[email protected] [email protected]
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Pages 134-143 | Received 02 Jun 2018, Accepted 29 Jul 2018, Published online: 04 Nov 2018

Citations (12)

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Kanika Verma, Panupong Mahalapbutr, Atima Auepattanapong, Onnicha Khaikate, Chutima Kuhakarn, Kaito Takahashi & Thanyada Rungrotmongkol. (2022) Molecular dynamics simulations of sulfone derivatives in complex with DNA topoisomerase IIα ATPase domain. Journal of Biomolecular Structure and Dynamics 40:4, pages 1692-1701.
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Yang Li, Ying Sun, Yang Zhou, Xinyang Li, Huan Zhang & Guojun Zhang. (2021) Discovery of orally active chalcones as histone lysine specific demethylase 1 inhibitors for the treatment of leukaemia. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 207-217.
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Articles from other publishers (10)

Isis A. Y. Ventura-Salazar, Francisco J. Palacios-Can, Leticia González-Maya, Jessica Nayelli Sánchez-Carranza, Mayra Antunez-Mojica, Rodrigo Said Razo-Hernández & Laura Alvarez. (2023) Finding a Novel Chalcone–Cinnamic Acid Chimeric Compound with Antiproliferative Activity against MCF-7 Cell Line Using a Free-Wilson Type Approach. Molecules 28:14, pages 5486.
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Fernando Ferreira Leite, Natália Ferreira de Sousa, Bruno Hanrry Melo de Oliveira, Gabrielly Diniz Duarte, Maria Denise Leite Ferreira, Marcus Tullius Scotti, José Maria Barbosa Filho, Luís Cezar Rodrigues, Ricardo Olímpio de Moura, Francisco Jaime Bezerra Mendonça-Junior & Luciana Scotti. (2023) Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies. Molecules 28:10, pages 4009.
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Kanpong Boonthaworn, Kowit Hengphasatporn, Yasuteru Shigeta, Warinthorn Chavasiri, Thanyada Rungrotmongkol & Puey Ounjai. (2023) In silico screening of chalcones and flavonoids as potential inhibitors against yellow head virus 3C-like protease. PeerJ 11, pages e15086.
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Amr Ahmed WalyEldeen, Salwa Sabet, Haidan M. El-Shorbagy, Ismail A. Abdelhamid & Sherif Abdelaziz Ibrahim. (2023) Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer. Chemico-Biological Interactions 369, pages 110297.
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Yali Song, Xinyue Zhu, Kan Yang, Siran Feng, Yiwen Zhang, Jinjiao Dong, Zhenming Liu & Xiaoqiang Qiao. (2022) Synthesis and biological evaluation of xanthone derivatives as anti-cancer agents targeting topoisomerase II and DNA. Medicinal Chemistry Research 31:5, pages 720-734.
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Yinuo Fei, Yan Shao, Weiwei Wang, Yatian Cheng, Boyang Yu, Xiaorong He & Jian Zhang. (2021) Biosynthesis of Three Chalcone β-D-glucosides by Glycosyltransferase from Bacillus subtilis ATCC 6633 . Microbiology and Biotechnology Letters 49:2, pages 174-180.
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Sidharth Mehan, Saloni Rahi, Shubham Upadhayay & Andleeb Khan. 2021. Polyphenols-based Nanotherapeutics for Cancer Management. Polyphenols-based Nanotherapeutics for Cancer Management 95 141 .
Mariia Radaeva, Xuesen Dong & Artem Cherkasov. (2020) The Use of Methods of Computer-Aided Drug Discovery in the Development of Topoisomerase II Inhibitors: Applications and Future Directions. Journal of Chemical Information and Modeling 60:8, pages 3703-3721.
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Yali Song, Siran Feng, Jiajia Feng, Jinjiao Dong, Kan Yang, Zhenming Liu & Xiaoqiang Qiao. (2020) Synthesis and biological evaluation of novel pyrazoline derivatives containing indole skeleton as anti-cancer agents targeting topoisomerase II. European Journal of Medicinal Chemistry 200, pages 112459.
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Kanyani Sangpheak, Lueacha Tabtimmai, Supaphorn Seetaha, Chompoonut Rungnim, Warinthorn Chavasiri, Peter Wolschann, Kiattawee Choowongkomon & Thanyada Rungrotmongkol. (2019) Biological Evaluation and Molecular Dynamics Simulation of Chalcone Derivatives as Epidermal Growth Factor-Tyrosine Kinase Inhibitors. Molecules 24:6, pages 1092.
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