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Francesco Liguori, Simone Carradori, Roberto Ronca, Sara Rezzola, Serena Filiberti, Fabrizio Carta, Marta Turati & Claudiu T. Supuran. (2022) Benzenesulfonamides with different rigidity-conferring linkers as carbonic anhydrase inhibitors: an insight into the antiproliferative effect on glioblastoma, pancreatic, and breast cancer cells. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1857-1869.
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Mateusz Kciuk, Adrianna Gielecińska, Somdutt Mujwar, Mariusz Mojzych, Beata Marciniak, Rafał Drozda & Renata Kontek. (2022) Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1278-1298.
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Claudiu T. Supuran. (2020) An update on drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors. Expert Opinion on Drug Metabolism & Toxicology 16:4, pages 297-307.
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Francesca Mancuso, Laura De Luca, Andrea Angeli, Sonia Del Prete, Clemente Capasso, Claudiu T. Supuran & Rosaria Gitto. (2020) Synthesis, computational studies and assessment of in vitro inhibitory activity of umbelliferon-based compounds against tumour-associated carbonic anhydrase isoforms IX and XII. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1442-1449.
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Jessica Ruzzolini, Anna Laurenzana, Elena Andreucci, Silvia Peppicelli, Francesca Bianchini, Fabrizio Carta, Claudiu T. Supuran, Maria Novella Romanelli, Chiara Nediani & Lido Calorini. (2020) A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 391-397.
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Articles from other publishers (59)
Seham A. Ibrahim, Saedah R. Al-Mhyawi & Faten M. Atlam. (2023) New imidazole-2-ones and their 2-thione analogues as anticancer agents and CAIX inhibitors: Synthesis, in silico ADME and molecular modeling studies. Bioorganic Chemistry 141, pages 106872.
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Toni C. Denner, Andrea Angeli, Marta Ferraroni, Claudiu T. Supuran & René Csuk. (2023) Ureidobenzenesulfonamides as Selective Carbonic Anhydrase I, IX, and XII Inhibitors. Molecules 28:23, pages 7782.
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Elena Andreucci, Alessio Biagioni, Sara Peri, Giampaolo Versienti, Fabio Cianchi, Fabio Staderini, Lorenzo Antonuzzo, Claudiu T. Supuran, Erika Olivo, Elisa Pasqualini, Luca Messerini, Daniela Massi, Matteo Lulli, Jessica Ruzzolini, Silvia Peppicelli, Francesca Bianchini, Nicola Schiavone, Lido Calorini, Lucia Magnelli & Laura Papucci. (2023) The CAIX inhibitor SLC-0111 exerts anti-cancer activity on gastric cancer cell lines and resensitizes resistant cells to 5-Fluorouracil, taxane-derived, and platinum-based drugs. Cancer Letters 571, pages 216338.
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Archana Sharma, Diksha Sharma, Neha Saini, Sunil V. Sharma, Vijay Kumar Thakur, Ramesh K. Goyal & Prabodh Chander Sharma. (2023) Recent advances in synthetic strategies and SAR of thiazolidin-4-one containing molecules in cancer therapeutics. Cancer and Metastasis Reviews 42:3, pages 847-889.
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Marta Venturella, Alessandro Falsini, Federica Coppola, Gaia Giuntini, Fabio Carraro, Davide Zocco, Antonio Chiesi & Antonella Naldini. (2023) CA-IX-Expressing Small Extracellular Vesicles (sEVs) Are Released by Melanoma Cells under Hypoxia and in the Blood of Advanced Melanoma Patients. International Journal of Molecular Sciences 24:7, pages 6122.
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Annachiara Sarnella, Ylenia Ferrara, Sandra Albanese, Daniela Omodei, Laura Cerchia, Giuseppina De Simone, Claudiu T. Supuran & Antonella Zannetti. (2023) Inhibition of Bone Marrow-Mesenchymal Stem Cell-Induced Carbonic Anhydrase IX Potentiates Chemotherapy Efficacy in Triple-Negative Breast Cancer Cells. Cells 12:2, pages 298.
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Ashok Aspatwar, Claudiu T. Supuran, Abdul Waheed, William S. Sly & Seppo Parkkila. (2022) Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease. The Journal of Physiology 601:2, pages 257-274.
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Annachiara Sarnella, Ylenia Ferrara, Luigi Auletta, Sandra Albanese, Laura Cerchia, Vincenzo Alterio, Giuseppina De Simone, Claudiu T. Supuran & Antonella Zannetti. (2022) Inhibition of carbonic anhydrases IX/XII by SLC-0111 boosts cisplatin effects in hampering head and neck squamous carcinoma cell growth and invasion. Journal of Experimental & Clinical Cancer Research 41:1.
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Sherif O. Kolade, Josephat U. Izunobi, Allen T. Gordon, Eric C. Hosten, Idris A. Olasupo, Adeniyi S. Ogunlaja, Olayinka T. Asekun & Oluwole B. Familoni. (2022)
N
-Cycloamino substituent effects on the packing architecture of
ortho
-sulfanilamide molecular crystals and their
in silico
carbonic anhydrase II and IX inhibitory activities
. Acta Crystallographica Section C Structural Chemistry 78:12, pages 730-742.
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Heba T. Abdel‐Mohsen, Mohamed A. Omar, Andrea Petreni & Claudiu T. Supuran. (2022) Novel 2‐substituted thioquinazoline‐benzenesulfonamide derivatives as carbonic anhydrase inhibitors with potential anticancer activity. Archiv der Pharmazie 355:12.
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Xinyang Zhong, Xuefeng He, Yaxian Wang, Zijuan Hu, Huixia Huang, Senlin Zhao, Ping Wei & Dawei Li. (2022) Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications. Journal of Hematology & Oncology 15:1.
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Aarfa Queen, Humaira Naaz Bhutto, Mohd Yousuf, Mansoor Ali Syed & Md. Imtaiyaz Hassan. (2022) Carbonic anhydrase IX: A tumor acidification switch in heterogeneity and chemokine regulation. Seminars in Cancer Biology 86, pages 899-913.
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Alison M. Ferguson & Mark A. Rubin. (2022) Lineage plasticity in prostate cancer: Looking beyond intrinsic alterations. Cancer Letters 548, pages 215901.
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N. Kılınç, U. Güller & Z. Alım. (2022) Identification of the Inhibition Effects of Some Natural Antiproliferative Agents on CA-I, CA-II, and AChE Activities Isolated from Human Erythrocytes by Kinetic and Molecular Docking Studies. Russian Journal of Bioorganic Chemistry 48:4, pages 720-730.
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Paul C. McDonald, Shawn C. Chafe, Claudiu T. Supuran & Shoukat Dedhar. (2022) Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside. Cancers 14:14, pages 3297.
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Afrah E. Mohammed, Fuad Ameen, Kawther Aabed, Rasha Saad Suliman, Sahar Saleh Alghamdi, Fatmah Ahmed Safhi, Dalal Sulaiman Alshaya, Hayat Ali Alafari, Areej S. Jalal, Areej A. Alosaimi, Salha Mesfer Alshamrani & Ishrat Rahman. (2022) In-silico predicting as a tool to develop plant-based biomedicines and nanoparticles: Lycium shawii metabolites. Biomedicine & Pharmacotherapy 150, pages 113008.
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Nuri YORULMAZ, Hilal ÖZTÜRK & Mustafa DURGUN. (2022) Evaluation of Some Sulfonamide Derivatives as a Potential Inhibitors of The Carbonic Anhydrase IX/XII by ADME and Molecular Docking Method. Adıyaman University Journal of Science.
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Richard E. Kast, Alex Alfieri, Hazem I. Assi, Terry C. Burns, Ashraf M. Elyamany, Maria Gonzalez-Cao, Georg Karpel-Massler, Christine Marosi, Michael E. Salacz, Iacopo Sardi, Pieter Van Vlierberghe, Mohamed S. Zaghloul & Marc-Eric Halatsch. (2022) MDACT: A New Principle of Adjunctive Cancer Treatment Using Combinations of Multiple Repurposed Drugs, with an Example Regimen. Cancers 14:10, pages 2563.
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Tomas Koltai, Stephan Joel Reshkin, Tiago M. A. Carvalho, Daria Di Molfetta, Maria Raffaella Greco, Khalid Omer Alfarouk & Rosa Angela Cardone. (2022) Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma: A Physiopathologic and Pharmacologic Review. Cancers 14:10, pages 2486.
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Ismail Koyuncu, Ebru Temiz, Mustafa Durgun, Abdurrahim Kocyigit, Ozgur Yuksekdag & Claudiu T. Supuran. (2022) Intracellular pH-mediated induction of apoptosis in HeLa cells by a sulfonamide carbonic anhydrase inhibitor. International Journal of Biological Macromolecules 201, pages 37-46.
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Mark Samuels, Chiara Cilibrasi, Panagiotis Papanastasopoulos & Georgios Giamas. (2022) Extracellular Vesicles as Mediators of Therapy Resistance in the Breast Cancer Microenvironment. Biomolecules 12:1, pages 132.
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Manzoor Ahmad Mir & Burhan ul Haq. 2022. Role of Tumor Microenvironment in Breast Cancer and Targeted Therapies. Role of Tumor Microenvironment in Breast Cancer and Targeted Therapies
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Stanislav Kalinin, Anna Malkova, Tatiana Sharonova, Vladimir Sharoyko, Alexander Bunev, Claudiu T. Supuran & Mikhail Krasavin. (2021) Carbonic Anhydrase IX Inhibitors as Candidates for Combination Therapy of Solid Tumors. International Journal of Molecular Sciences 22:24, pages 13405.
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Fangli Chen, Emilia Licarete, Xue Wu, Daniela Petrusca, Callista Maguire, Max Jacobsen, Austyn Colter, George E. Sandusky, Magdalena Czader, Maegan L. Capitano, James P. Ropa, H. Scott Boswell, Fabrizio Carta, Claudiu T. Supuran, Brian Parkin, Melissa L. Fishel & Heiko Konig. (2021) Pharmacological inhibition of Carbonic Anhydrase IX and XII to enhance targeting of acute myeloid leukaemia cells under hypoxic conditions. Journal of Cellular and Molecular Medicine 25:24, pages 11039-11052.
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Dean C. Singleton, Andrew Macann & William R. Wilson. (2021) Therapeutic targeting of the hypoxic tumour microenvironment. Nature Reviews Clinical Oncology 18:12, pages 751-772.
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Rui Hou, Yan He, Guangwei Yan, Shuzeng Hou, Zhouling Xie & Chenzhong Liao. (2021) Zinc enzymes in medicinal chemistry. European Journal of Medicinal Chemistry 226, pages 113877.
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Priyanila Magesh, Sanu Thankachan, Thejaswini Venkatesh & Padmanaban S. Suresh. (2021) Breast cancer fibroblasts and cross-talk. Clinica Chimica Acta 521, pages 158-169.
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Silvia A. Teixeira, Mariano S. Viapiano, Augusto F. Andrade, Mohan S. Nandhu, Julia A. Pezuk, Lucas T. Bidinotto, Veridiana K. Suazo, Luciano Neder, Carlos G. Carlotti, Aline P. Becker, Luiz Gonzaga Tone & Carlos A. Scrideli. (2021) The Carbonic Anhydrase Inhibitor E7070 Sensitizes Glioblastoma Cells to Radio- and Chemotherapy and Reduces Tumor Growth. Molecular Neurobiology 58:9, pages 4520-4534.
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Shamin Azwar, Heng Fong Seow, Maha Abdullah, Mohd Faisal Jabar & Norhafizah Mohtarrudin. (2021) Recent Updates on Mechanisms of Resistance to 5-Fluorouracil and Reversal Strategies in Colon Cancer Treatment. Biology 10:9, pages 854.
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Antje Güttler, Yvonne Eiselt, Anne Funtan, Andreas Thiel, Marina Petrenko, Jacqueline Keßler, Iris Thondorf, Reinhard Paschke, Dirk Vordermark & Matthias Bache. (2021) Betulin Sulfonamides as Carbonic Anhydrase Inhibitors and Anticancer Agents in Breast Cancer Cells. International Journal of Molecular Sciences 22:16, pages 8808.
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Mohamed T. M. Nemr, Asmaa M. AboulMagd, Hossam M. Hassan, Ahmed A. Hamed, Mohamed I. A. Hamed & Mohamed T. Elsaadi. (2021)
Design, synthesis and mechanistic study of new benzenesulfonamide derivatives as anticancer and antimicrobial agents
via
carbonic anhydrase IX inhibition
. RSC Advances 11:42, pages 26241-26257.
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Na Xu, Wujie Lu, Lijie Meng, Xu Feng, Jingjing Xuan, Fangfang Liu & Zhijun Feng. (2021) Carbonic anhydrase inhibition, antioxidant activity against alveolar epithelial cells and antibacterial effect against Klebsiella pneumoniae enabled by synthesized silica nanoparticles through laser ablation technique. Life Sciences 278, pages 119032.
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Francesca Mancuso, Anna Di Fiore, Laura De Luca, Andrea Angeli, Giuseppina De Simone, Claudiu T. Supuran & Rosaria Gitto. (2021) Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII. Bioorganic & Medicinal Chemistry 44, pages 116279.
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Mohammad M. Al-Sanea, Garri Chilingaryan, Narek Abelyan, Grigor Arakelov, Harutyun Sahakyan, Vahram G. Arakelov, Karen Nazaryan, Shaimaa Hussein, Gharam M. Alazmi, Haifa E. Alsharari, Waad M. Al-faraj, Faten S. Alruwaili, Nouf Q. Albilasi, Tahani S. Alsharari, Abdulaziz A. S. Alsaleh, Turki M. Alazmi, Atiah H. Almalki, Nasser H. Alotaibi & Mohamed A. Abdelgawad. (2021) Identification of non-classical hCA XII inhibitors using combination of computational approaches for drug design and discovery. Scientific Reports 11:1.
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Giuseppina De Simone, Silvia Bua, Claudiu T. Supuran & Vincenzo Alterio. (2021) Benzyl alcohol inhibits carbonic anhydrases by anchoring to the zinc coordinated water molecule. Biochemical and Biophysical Research Communications 548, pages 217-221.
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Mam Y. Mboge, Jacob Combs, Srishti Singh, Jacob Andring, Alyssa Wolff, Chingkuang Tu, Zaihui Zhang, Robert McKenna & Susan C. Frost. (2021) Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer. Journal of Medicinal Chemistry 64:3, pages 1713-1724.
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Carolina Bernauer, Y. K. Stella Man, Julia C. Chisholm, Elise Y. Lepicard, Simon P. Robinson & Janet M. Shipley. (2020) Hypoxia and its therapeutic possibilities in paediatric cancers. British Journal of Cancer 124:3, pages 539-551.
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Shubham Kumar, Sandeep Rulhania, Shalini Jaswal & Vikramdeep Monga. (2021) Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors. European Journal of Medicinal Chemistry 209, pages 112923.
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Agostino Bruno & Gabriele Costantino. 2021. pH-Interfering Agents as Chemosensitizers in Cancer Therapy. pH-Interfering Agents as Chemosensitizers in Cancer Therapy
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Joonas Haapasalo, Kristiina Nordfors & Seppo Parkkila. 2021. pH-Interfering Agents as Chemosensitizers in Cancer Therapy. pH-Interfering Agents as Chemosensitizers in Cancer Therapy
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Shimpei Iikuni, Hiroyuki Watanabe, Yoichi Shimizu, Yuji Nakamoto & Masahiro Ono. (2020) PET imaging and pharmacological therapy targeting carbonic anhydrase-IX high-expressing tumors using US2 platform based on bivalent ureidosulfonamide. PLOS ONE 15:12, pages e0243327.
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Annachiara Sarnella, Giuliana D’Avino, Billy Samuel Hill, Vincenzo Alterio, Jean-Yves Winum, Claudiu T. Supuran, Giuseppina De Simone & Antonella Zannetti. (2020) A Novel Inhibitor of Carbonic Anhydrases Prevents Hypoxia-Induced TNBC Cell Plasticity. International Journal of Molecular Sciences 21:21, pages 8405.
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Jack Ashton & Robert Bristow. (2020) Bad neighbours: hypoxia and genomic instability in prostate cancer. The British Journal of Radiology 93:1115, pages 20200087.
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Pavitra S. Thacker, Nerella Sridhar Goud, Omkar S. Argulwar, Jyothsna Soman, Andrea Angeli, Mallika Alvala, Mohammed Arifuddin & Claudiu T. Supuran. (2020) Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. Bioorganic Chemistry 104, pages 104272.
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Krishnakishore Majalakere, Sarojini Balladka Kunhana, Shama Rao, Bhuvanesh Sukhlal Kalal, Narayana Badiadka, Ganesh Sanjeev & Bantwal Shivaram Holla. (2020) Studies on imidazo[2,1-b][1,3]benzothiazole derivatives as new radiosensitizers. SN Applied Sciences 2:11.
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Salvador Harguindey, Khalid Alfarouk, Julián Polo Orozco, Stefano Fais & Jesús Devesa. (2020) Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era. International Journal of Molecular Sciences 21:20, pages 7475.
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Elena Andreucci, Silvia Peppicelli, Jessica Ruzzolini, Francesca Bianchini, Alessio Biagioni, Laura Papucci, Lucia Magnelli, Benedetta Mazzanti, Barbara Stecca & Lido Calorini. (2020) The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells. Journal of Molecular Medicine 98:10, pages 1431-1446.
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Yosselin Huentupil, Patricio Chung, Néstor Novoa, Rodrigo Arancibia, Pascal Roussel, Juan Oyarzo, A. Hugo Klahn, Carlos Silva, Carme Calvis, Ramon Messeguer, Ramón Bosque & Concepción López. (2020)
Novel multifunctional and multitarget homo- (Fe
2
) and heterobimetallic [(Fe,M) with M = Re or Mn] sulfonyl hydrazones
. Dalton Transactions 49:35, pages 12249-12265.
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Francesca Mancuso, Anna Di Fiore, Laura De Luca, Andrea Angeli, Simona M. Monti, Giuseppina De Simone, Claudiu T. Supuran & Rosaria Gitto. (2020) Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms. ACS Medicinal Chemistry Letters 11:5, pages 1000-1005.
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Jacob Andring, Jacob Combs & Robert McKenna. (2020) Aspirin: A Suicide Inhibitor of Carbonic Anhydrase II. Biomolecules 10:4, pages 527.
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Y. Garcia-Mayea, C. Mir, F. Masson, R. Paciucci & M.E. LLeonart. (2020) Insights into new mechanisms and models of cancer stem cell multidrug resistance. Seminars in Cancer Biology 60, pages 166-180.
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Shangwei Zhong, Ji-Hak Jeong, Zhikang Chen, Zihua Chen & Jun-Li Luo. (2020) Targeting Tumor Microenvironment by Small-Molecule Inhibitors. Translational Oncology 13:1, pages 57-69.
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Tomas Koltai, Stephan J. Reshkin & Salvador Harguindey. 2020. An Innovative Approach to Understanding and Treating Cancer: Targeting pH. An Innovative Approach to Understanding and Treating Cancer: Targeting pH
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Kaye J. Williams & Roben G. Gieling. (2019) Preclinical Evaluation of Ureidosulfamate Carbonic Anhydrase IX/XII Inhibitors in the Treatment of Cancers. International Journal of Molecular Sciences 20:23, pages 6080.
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Immo Serbian, Philipp Schwarzenberger, Anne Loesche, Sophie Hoenke, Ahmed Al-Harrasi & René Csuk. (2019) Ureidobenzenesulfonamides as efficient inhibitors of carbonic anhydrase II. Bioorganic Chemistry 91, pages 103123.
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Paul C. McDonald, Shawn C. Chafe, Wells S. Brown, Saeed Saberi, Mridula Swayampakula, Geetha Venkateswaran, Oksana Nemirovsky, Jordan A. Gillespie, Joanna M. Karasinska, Steve E. Kalloger, Claudiu T. Supuran, David F. Schaeffer, Ali Bashashati, Sohrab P. Shah, James T. Topham, Donald T. Yapp, Jinyang Li, Daniel J. Renouf, Ben Z. Stanger & Shoukat Dedhar. (2019) Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia. Gastroenterology 157:3, pages 823-837.
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Rosa Cardone, Khalid Alfarouk, Robert Elliott, Saad Alqahtani, Samrein Ahmed, Ahmed Aljarbou, Maria Greco, Stefania Cannone & Stephan Reshkin. (2019) The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequela. International Journal of Molecular Sciences 20:15, pages 3694.
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Kerem Buran, Silvia Bua, Giulio Poli, F. Önen Bayram, Tiziano Tuccinardi & Claudiu T. Supuran. (2019) Novel 8-Substituted Coumarins That Selectively Inhibit Human Carbonic Anhydrase IX and XII. International Journal of Molecular Sciences 20:5, pages 1208.
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Marc A. Ilies & Jean-Yves Winum. 2019. Carbonic Anhydrases. Carbonic Anhydrases
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