1,653
Views
41
CrossRef citations to date
0
Altmetric
Research Paper

Novel sulfonamide benzoquinazolinones as dual EGFR/HER2 inhibitors, apoptosis inducers and radiosensitizers

, &
Pages 1030-1040 | Received 27 Feb 2019, Accepted 15 Apr 2019, Published online: 10 May 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Seohyun Son, Ahmed Elkamhawy, Anam Rana Gul, Ahmed A. Al‐Karmalawy, Radwan Alnajjar, Ahmed Abdeen, Samah F. Ibrahim, Saud O. Alshammari, Qamar A. Alshammari, Won Jun Choi, Tae Jung Park & Kyeong Lee. (2023) Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell lines. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
Read now
Longjia Yan, Qin Wang, Li Liu & Yi Le. (2022) Design, synthesis and biological evaluation of a series of dianilinopyrimidines as EGFR inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 832-843.
Read now
Mona F. Said, Riham F. George, Andrea Petreni, Claudiu T. Supuran & Nada M. Mohamed. (2022) Synthesis, molecular modelling and QSAR study of new N-phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 701-717.
Read now
Mostafa M. Ghorab, Maged S. Abdel-Kader, Ali S. Alqahtani & Aiten M. Soliman. (2021) Synthesis of some quinazolinones inspired from the natural alkaloid L-norephedrine as EGFR inhibitors and radiosensitizers. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 218-238.
Read now

Articles from other publishers (37)

Reihane Ghomashi, Shakila Ghomashi, Hamidreza Aghaei, Samineh Massah & Ahmad Reza Massah. (2023) Recent Advances in Biological Active Sulfonamide based Hybrid Compounds Part C: Multicomponent Sulfonamide Hybrids. Current Medicinal Chemistry 30:37, pages 4181-4255.
Crossref
Mostafa M. Ghorab, Aiten M. Soliman, Khaled El-Adl & Noura S. Hanafy. (2023) New quinazoline sulfonamide derivatives as potential anticancer agents: Identifying a promising hit with dual EGFR/VEGFR-2 inhibitory and radiosensitizing activity. Bioorganic Chemistry 140, pages 106791.
Crossref
Salwa Magdy Eldaly, Dalia Salama Zakaria & Nadia Hanafy Metwally. (2023) Design, Synthesis, Anticancer Evaluation and Molecular Modeling Studies of New Thiazolidinone‐Benzoate Scaffold as EGFR Inhibitors, Cell Cycle Interruption and Apoptosis Inducers in HepG2. Chemistry & Biodiversity 20:10.
Crossref
Aiten M. Soliman, Walid M. Ghorab, Dina M. Lotfy, Heba M. Karam, Mostafa M. Ghorab & Laila A. Ramadan. (2023) Novel iodoquinazolinones bearing sulfonamide moiety as potential antioxidants and neuroprotectors. Scientific Reports 13:1.
Crossref
Mohammad Mavvaji & Senem Akkoc. (2023) Recent Advances in the Anticancer Applications of Benzimidazole Derivatives. ChemistrySelect 8:35.
Crossref
Mostafa GM El-Gazzar, Marwa G El-Gazzar & Mostafa M Ghorab. (2023) Quinazolinone derivatives as new potential CDK4/6 inhibitors, apoptosis inducers and radiosensitizers for breast cancer. Future Medicinal Chemistry.
Crossref
Bokang Zhang, Wan Yang & Lanren Chen. (2023) Secreted phosphoprotein 1 exacerbates renal ischemia-reperfusion injury by inhibiting PI3K/AKT signaling pathway. Tissue and Cell 83, pages 102154.
Crossref
Rohit Pal, Ghanshyam Teli, Gurubasavaraja Swamy Purawarga Matada & Prasad Sanjay Dhiwar. (2023) Nitrogen‐Containing Heterocyclic Scaffolds as EGFR Inhibitors: Design Approaches, Molecular Docking, and Structure‐Activity Relationships. ChemistrySelect 8:26.
Crossref
Eman M. Alghamdi, Zahra M. Alamshany, Mohamed A. El Hamd, Ehab S. Taher, Mohammed Farrag El‐Behairy, Philip L. Norcott & Adel A. Marzouk. (2023) Anticancer Activities of Tetrasubstituted Imidazole‐Pyrimidine‐Sulfonamide Hybrids as Inhibitors of EGFR Mutants. ChemMedChem 18:8.
Crossref
Hatem A. Abuelizz & Rashad Al-Salahi. (2023) Significant pharmacological activities of benzoquinazolines scaffold. Pharmacological Reports 75:2, pages 223-235.
Crossref
Mostafa M Ghorab, Ali S Alqahtani, Aiten M Soliman & Ahmed A Askar. (2023) Antimicrobial, anticancer and immunomodulatory potential of new quinazolines bearing benzenesulfonamide moiety. Future Medicinal Chemistry 15:3, pages 275-290.
Crossref
Rudradip Das, Gayatri Tambe & Amit Shard. (2023) Sulfonamides as tyrosine kinase modulators – A promising class of anticancer agents. Results in Chemistry 5, pages 100950.
Crossref
Kunyu Shi, Guan Wang, Junping Pei, Jifa Zhang, Jiaxing Wang, Liang Ouyang, Yuxi Wang & Weimin Li. (2022) Emerging strategies to overcome resistance to third-generation EGFR inhibitors. Journal of Hematology & Oncology 15:1.
Crossref
Jing Wang, Liwei Huang, Xi Chen, Yangchen Yuan, Juan Sun & Meng Yang. (2022) Design, Synthesis and Antitumor Activities of Novel Quinazolinone Derivatives as Potential EGFR Inhibitors. Chemical and Pharmaceutical Bulletin 70:9, pages 637-641.
Crossref
Bhupender Nehra, Bijo Mathew & Pooja A. Chawla. (2022) A Medicinal Chemist’s Perspective Towards Structure Activity Relationship of Heterocycle Based Anticancer Agents. Current Topics in Medicinal Chemistry 22:6, pages 493-528.
Crossref
Rasha Z. Batran, Sherien M. El‐Daly, Walaa A. El‐Kashak & Eman Y. Ahmed. (2022) Design, synthesis, and molecular modeling of quinoline‐based derivatives as anti‐breast cancer agents targeting EGFR/AKT signaling pathway. Chemical Biology & Drug Design 99:3, pages 470-482.
Crossref
Lingling Li & Hailiang Huang. (2022) Potential Targets and Molecular Mechanism of Quercetin Against Knee Osteoarthritis. Chinese medicine and natural products 02:01, pages e32-e43.
Crossref
Liping Hu, Mengmeng Fan, Shengmin Shi, Xiaomeng Song, Fei Wang, Huan He & Baohui Qi. (2022) Dual target inhibitors based on EGFR: Promising anticancer agents for the treatment of cancers (2017-). European Journal of Medicinal Chemistry 227, pages 113963.
Crossref
Hafeez Anwar, Beenish Abbas, Maryam Khalid, Kamila Yunas, Hamed Nosrati, Hossein Danafar & Surender K. Sharma. 2022. Harnessing Materials for X-ray Based Cancer Therapy and Imaging. Harnessing Materials for X-ray Based Cancer Therapy and Imaging 77 134 .
Essam M. Hussein, M. Shaheer Malik, Reem I. Alsantali, Basim H. Asghar, Moataz Morad, Mohammad Azam Ansari, Qazi Mohammad Sajid Jamal, Abdulrahman A. Alsimaree, Ashraf N. Abdalla, Alanood S. Algarni, Rabab S. Jassas, Hatem M. Altass & Saleh A. Ahmed. (2021) Bioactive fluorenes. Part IV: Design, synthesis, and a combined in vitro, in silico anticancer and antibacterial evaluation of new fluorene-heterocyclic sulfonamide conjugates. Journal of Molecular Structure 1246, pages 131232.
Crossref
Bu-Fan Xiao, Jing-Tao Zhang, Yu-Ge Zhu, Xin-Run Cui, Zhe-Ming Lu, Ben-Tong Yu & Nan Wu. (2021) Chimeric Antigen Receptor T-Cell Therapy in Lung Cancer: Potential and Challenges. Frontiers in Immunology 12.
Crossref
Bharti Sharma, Vikram Jeet Singh & Pooja A. Chawla. (2021) Epidermal growth factor receptor inhibitors as potential anticancer agents: An update of recent progress. Bioorganic Chemistry 116, pages 105393.
Crossref
Min Zou, Jiawen Li, Bo Jin, Mingsheng Wang, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao & Liyun Zheng. (2021) Design, synthesis and anticancer evaluation of new 4-anilinoquinoline-3-carbonitrile derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers. Bioorganic Chemistry 114, pages 105200.
Crossref
Heberth de Paula, Rafaela Molina Angelo & Kathia Maria Honorio. (2021) Topomer-CoMFA proposed as a tool to construct dual EGFR/HER-2 models. Journal of Molecular Modeling 27:9.
Crossref
Adil M. Dhumad, Ahmed M. Jassem, Raed A. Alharis & Faeza A. Almashal. (2021) Design, cytotoxic effects on breast cancer cell line (MDA-MB 231), and molecular docking of some maleimide-benzenesulfonamide derivatives. Journal of the Indian Chemical Society 98:4, pages 100055.
Crossref
Mostafa M. Ghorab, Aiten M. Soliman, Silvia Bua & Claudiu T. Supuran. (2021) Biological evaluation, radiosensitizing activity and structural insights of novel halogenated quinazoline-sulfonamide conjugates as selective human carbonic anhydrases IX/XII inhibitors. Bioorganic Chemistry 107, pages 104618.
Crossref
Noha H. Amin, Mohammed T. Elsaadi, Shimaa S. Zaki & Hamdy M. Abdel-Rahman. (2020) Design, synthesis and molecular modeling studies of 2-styrylquinazoline derivatives as EGFR inhibitors and apoptosis inducers. Bioorganic Chemistry 105, pages 104358.
Crossref
Eman A. Abd El-Meguid, Eman M. Mohi El-Deen, Manal A. Nael & Manal M. Anwar. (2020) Novel benzimidazole derivatives as anti-cervical cancer agents of potential multi-targeting kinase inhibitory activity. Arabian Journal of Chemistry 13:12, pages 9179-9195.
Crossref
Parth Bhatia, Vrinda Sharma, Ozair Alam, Ajay Manaithiya, Perwaiz Alam, Kahksha, Md Tauquir Alam & Mohd Imran. (2020) Novel quinazoline-based EGFR kinase inhibitors: A review focussing on SAR and molecular docking studies (2015-2019). European Journal of Medicinal Chemistry 204, pages 112640.
Crossref
Nadjet Rezki, Meshal A. Almehmadi, Saleh Ihmaid, Ahmed M. Shehata, Abdelsattar M. Omar, Hany E.A. Ahmed & Mohamed Reda Aouad. (2020) Novel scaffold hopping of potent benzothiazole and isatin analogues linked to 1,2,3-triazole fragment that mimic quinazoline epidermal growth factor receptor inhibitors: Synthesis, antitumor and mechanistic analyses. Bioorganic Chemistry 103, pages 104133.
Crossref
Aladdin M. Srour, Nesreen S. Ahmed, Somaia S. Abd El-Karim, Manal M. Anwar & Salwa M. El-Hallouty. (2020) Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors. Bioorganic & Medicinal Chemistry 28:18, pages 115657.
Crossref
Marion Peyressatre, Dominique Patomo Arama, Arthur Laure, Juan A. González-Vera, Morgan Pellerano, Nicolas Masurier, Vincent Lisowski & May C. Morris. (2020) Identification of Quinazolinone Analogs Targeting CDK5 Kinase Activity and Glioblastoma Cell Proliferation. Frontiers in Chemistry 8.
Crossref
Aiten M. Soliman, Heba M. Karam, Mai H. Mekkawy, Maureen Higgins, Albena T. Dinkova-Kostova & Mostafa M. Ghorab. (2020) Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety. European Journal of Medicinal Chemistry 200, pages 112467.
Crossref
Aiten M. Soliman, Mostafa M. Ghorab, Silvia Bua & Claudiu T. Supuran. (2020) Iodoquinazolinones bearing benzenesulfonamide as human carbonic anhydrase I, II, IX and XII inhibitors: Synthesis, biological evaluation and radiosensitizing activity. European Journal of Medicinal Chemistry 200, pages 112449.
Crossref
Shailima Rampogu, Gihwan Lee, Ravinder Doneti & Keun Woo Lee. (2020) Short communication for targeting natural compounds against HER2 kinase domain as potential anticancer drugs applying pharmacophore based molecular modelling approaches- part 2. Computational Biology and Chemistry 87, pages 107242.
Crossref
Aiten M. Soliman, Heba M. Karam, Mai H. Mekkawy & Mostafa M. Ghorab. (2020) Antioxidant activity of novel quinazolinones bearing sulfonamide: Potential radiomodulatory effects on liver tissues via NF-κB/ PON1 pathway. European Journal of Medicinal Chemistry 197, pages 112333.
Crossref
Srikanth Gatadi, Gauthami Pulivendala, Jitendra Gour, Satyaveni Malasala, Sushmitha Bujji, Ramulu Parupalli, Mujahid Shaikh, Chandraiah Godugu & Srinivas Nanduri. (2020) Synthesis and evaluation of new 4(3H)-Quinazolinone derivatives as potential anticancer agents. Journal of Molecular Structure 1200, pages 127097.
Crossref