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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 34, 2019 - Issue 1
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Short Communication

Antiproliferative activity and p53 upregulation effects of chalcones on human breast cancer cells

Mariana Bastos dos SantosDepartment of Chemistry and Environmental Chemistry, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São Paulo State University (UNESP), São Paulo, Brazil; View further author information
,
Daiane Bertholin AnselmoDepartment of Chemistry and Environmental Chemistry, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São Paulo State University (UNESP), São Paulo, Brazil; View further author information
,
Jéssica Gisleine de OliveiraDepartment of Molecular Biology, Medicine College of São José do Rio Preto (FAMERP), São Paulo, Brazil; View further author information
,
Bruna V. Jardim-PerassiDepartment of Molecular Biology, Medicine College of São José do Rio Preto (FAMERP), São Paulo, Brazil; View further author information
,
Diego Alves MonteiroDepartment of Biology, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São Paulo State University (UNESP), São Paulo, Brazil; View further author information
,
Gabriel SilvaBiotechnology Unit, University of Ribeirão Preto (UNAERP), São Paulo, BrazilView further author information
,
Eleni GomesDepartment of Biology, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São Paulo State University (UNESP), São Paulo, Brazil; View further author information
,
Ana Lucia FachinBiotechnology Unit, University of Ribeirão Preto (UNAERP), São Paulo, BrazilView further author information
,
Mozart MarinsBiotechnology Unit, University of Ribeirão Preto (UNAERP), São Paulo, BrazilView further author information
,
Débora Aparecida Pires de Campos ZuccariDepartment of Molecular Biology, Medicine College of São José do Rio Preto (FAMERP), São Paulo, Brazil; View further author information
&
Luis Octavio RegasiniDepartment of Chemistry and Environmental Chemistry, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São Paulo State University (UNESP), São Paulo, Brazil; Correspondence[email protected]
View further author information
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Pages 1093-1099 | Received 21 Mar 2019, Accepted 28 Apr 2019, Published online: 23 May 2019

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Peter A. Halim, Rasha A. Hassan, Khaled O. Mohamed, Soha O. Hassanin, Mona G. Khalil, Amr M. Abdou & Eman O. Osman. (2022) Synthesis and biological evaluation of halogenated phenoxychalcones and their corresponding pyrazolines as cytotoxic agents in human breast cancer. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 189-201.
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Yang Li, Ying Sun, Yang Zhou, Xinyang Li, Huan Zhang & Guojun Zhang. (2021) Discovery of orally active chalcones as histone lysine specific demethylase 1 inhibitors for the treatment of leukaemia. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 207-217.
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Articles from other publishers (29)

Xinyu Lin, Ying Wang, Kai Fang, Zijian Guo, Nan Lin & Lihua Li. (2023) The application of nanoparticles in theranostic systems targeting breast cancer stem cells: current progress and future challenges. Stem Cell Research & Therapy 14:1.
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Lígia R. Oliveira, Márcia R. Trein, Letícia R. Assis, Graziela V. Rigo, Leonardo P.M. Simões, Victor S. Batista, Alexandre J. Macedo, Danielle S. Trentin, Nailton M. Nascimento-Júnior, Tiana Tasca & Luis O. Regasini. (2023) Phenolic chalcones as agents against Trichomonas vaginalis. Bioorganic Chemistry 141, pages 106888.
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Zuzana Kudličková, Radka Michalková, Aneta Salayová, Marián Ksiažek, Mária Vilková, Slávka Bekešová & Ján Mojžiš. (2023) Design, Synthesis, and Evaluation of Novel Indole Hybrid Chalcones and Their Antiproliferative and Antioxidant Activity. Molecules 28:18, pages 6583.
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Imren Alioglu, Sibel Cinar-Asa, Demet Coskun & Ferda Ari. (2023) Benzofuran Substituted Chalcone Derivatives Trigger Apoptotic Cell Death Through Extrinsic Pathway in Human Lung and Breast Cancer Cells. Iranian Journal of Science 47:4, pages 1057-1069.
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Raad S. Jihad, Nabeel A. Abdul-Rida, Amer M. J. Al-Shamari, Najim A. Al-Masoudi & Bahjat A. Saeed. (2023) Design, synthesis, and in-silico study of new letrozole derivatives as prospective anticancer and antioxidant agents . Zeitschrift für Naturforschung B 78:6, pages 343-353.
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Xiangyi Kong, Yihang Qi, Xiangyu Wang, Rui Jiang, Jing Wang, Yi Fang, Jidong Gao & Kuo Chu Hwang. (2023) Nanoparticle drug delivery systems and their applications as targeted therapies for triple negative breast cancer. Progress in Materials Science 134, pages 101070.
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Vasudha Dadi, Rama Rao Malla & Satyalakshmi Siragam. (2023) Natural and Synthetic Chalcones: Potential Impact on Breast Cancer. Critical Reviews™ in Oncogenesis 28:4, pages 27-40.
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Eduardo A. Veliz, Anastasiia Kaplina, Sajini D. Hettiarachchi, Athina L. Yoham, Carolina Matta, Sabrin Safar, Meghana Sankaran, Esther L. Abadi, Emel Kirbas Cilingir, Frederic A. Vallejo, Winston M. Walters, Steven Vanni, Roger M. Leblanc & Regina M. Graham. (2022) Chalcones as Anti-Glioblastoma Stem Cell Agent Alone or as Nanoparticle Formulation Using Carbon Dots as Nanocarrier. Pharmaceutics 14:7, pages 1465.
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Luis Bustos, Carlos Echiburú-Chau, Alejandro Castro-Alvarez, Ben Bradshaw, Mario J. Simirgiotis, Marco Mellado, Claudio Parra & Mauricio Cuellar. (2022) Cytotoxic Effects on Breast Cancer Cell Lines of Chalcones Derived from a Natural Precursor and Their Molecular Docking Analysis. Molecules 27:14, pages 4387.
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Andréa Felinto Moura, Mirian Rita Carrilho de Castro, Raquel Ferreira Naves, Ana Jérsia Araújo, Maria Claudia Luciano dos Santos, José Delano Barreto Marinho Filho, Caridad Noda-Perez, Felipe Terra Martins, Claudia do O Pessoa & Manoel Odorico Moraes Filho. (2022) New Synthetic Sulfonamide Chalcone Induced Cell Cycle Arrest and Cell Death in Colorectal Adenocarcinoma Metastatic Cells (SW-620). Anti-Cancer Agents in Medicinal Chemistry 22:12, pages 2340-2351.
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Emanuel Paula Magalhães, Naiara Dutra Barroso Gomes, Tiago Araújo de Freitas, Brenna Pinheiro Silva, Lyanna Rodrigues Ribeiro, Francisco Wagner Queiroz Ameida-Neto, Márcia Machado Marinho, Pedro de Lima-Neto, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Alexandre Magno Rodrigues Teixeira, Tiago Lima Sampaio, Ramon Róseo Paula Pessoa Bezerra de Menezes & Alice Maria Costa Martins. (2022) Chloride substitution on 2-hydroxy-3,4,6-trimethoxyphenylchalcones improves in vitro selectivity on Trypanosoma cruzi strain Y. Chemico-Biological Interactions 361, pages 109920.
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Minru Liao, Rui Qin, Wei Huang, Hong-Ping Zhu, Fu Peng, Bo Han & Bo Liu. (2022) Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies. Journal of Hematology & Oncology 15:1.
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Mayara A.R. Garcia, Reinaldo S. Theodoro, Janaina C.O. Sardi, Mariana B. Santos, Gabriela M. Ayusso, Fernando R. Pavan, Alan R. Costa, Lucas M. Santa Cruz, Pedro L. Rosalen & Luis O. Regasini. (2021) Design, synthesis and antibacterial activity of chalcones against MSSA and MRSA planktonic cells and biofilms. Bioorganic Chemistry 116, pages 105279.
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Omaima M. AboulWafa, Hoda M. G. Daabees, Ali Hammad & Waleed A. Badawi. (2021) New functionalized 6‐thienylpyrimidine‐5‐carbonitriles as antiproliferative agents against human breast cancer cells. Archiv der Pharmazie 354:11.
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Daiane B. Anselmo, Carlos R. Polaquini, Beatriz C. Marques, Gabriela M. Ayusso, Letícia R. Assis, Guilherme S. Torrezan, Paula Rahal, Ana L. Fachin, Marília F. Calmon, Mozart A. Marins & Luis O. Regasini. (2021) Curcumin-cinnamaldehyde hybrids as antiproliferative agents against women’s cancer cells. Medicinal Chemistry Research.
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Fares Hezam Al-Ostoot, Zabiulla, Salma Salah & Shaukath Ara Khanum. (2021) Recent investigations into synthesis and pharmacological activities of phenoxy acetamide and its derivatives (chalcone, indole and quinoline) as possible therapeutic candidates. Journal of the Iranian Chemical Society 18:8, pages 1839-1875.
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Joana Moreira, Joana Almeida, Lucília Saraiva, Honorina Cidade & Madalena Pinto. (2021) Chalcones as Promising Antitumor Agents by Targeting the p53 Pathway: An Overview and New Insights in Drug-Likeness. Molecules 26:12, pages 3737.
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Yang Ouyang, Juanjuan Li, Xinyue Chen, Xiaoyu Fu, Si Sun & Qi Wu. (2021) Chalcone Derivatives: Role in Anticancer Therapy. Biomolecules 11:6, pages 894.
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G. O. Ismailova, N. M. Yuldashev, Kh. N. Akbarhodjaeva, M. M. Shertaev & Z. K. Ziyamutdinova. (2021) Biologically Active Natural 2'-Hydroxychalcones. Russian Journal of Bioorganic Chemistry 47:3, pages 660-669.
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Tomas Kuruc, Martin Kello, Klaudia Petrova, Zuzana Kudlickova, Peter Kubatka & Jan Mojzis. (2021) The Newly Synthetized Chalcone L1 Is Involved in the Cell Growth Inhibition, Induction of Apoptosis and Suppression of Epithelial-to-Mesenchymal Transition of HeLa Cells. Molecules 26:5, pages 1356.
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Shuai Gong, Shinji MaegawaYanwen YangVidya GopalakrishnanGuangrong Zheng & Donghang Cheng. (2021) Licochalcone A is a natural selective inhibitor of arginine methyltransferase 6. Biochemical Journal 478:2, pages 389-406.
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Rimsha Irfan, Shikufa Mousavi, Meshari Alazmi & Rahman Shah Zaib Saleem. (2020) A Comprehensive Review of Aminochalcones. Molecules 25:22, pages 5381.
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Li-Na Zhang, Yuan-Zheng Xia, Chao Zhang, Hao Zhang, Jian-Guang Luo, Lei Yang & Ling-Yi Kong. (2020) Vielanin K enhances doxorubicin-induced apoptosis via activation of IRE1α- TRAF2 - JNK pathway and increases mitochondrial Ca2 + influx in MCF-7 and MCF-7/MDR cells. Phytomedicine 78, pages 153329.
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Bharvi Sharma, Liang Gu, Ruvesh Pascal Pillay, Nosipho Cele, Paul Awolade, Parvesh Singh, Mandeep Kaur & Vipan Kumar. (2020) Design, synthesis, and anti-proliferative evaluation of 1 H -1,2,3-triazole grafted tetrahydro-β-carboline-chalcone/ferrocenylchalcone conjugates in estrogen responsive and triple negative breast cancer cells . New Journal of Chemistry 44:26, pages 11137-11147.
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Ahmed Dhahir Latif, Tamás Jernei, Ana Podolski-Renić, Ching-Ying Kuo, Máté Vágvölgyi, Gábor Girst, István Zupkó, Sedef Develi, Engin Ulukaya, Hui-Chun Wang, Milica Pešić, Antal Csámpai & Attila Hunyadi. (2020) Protoflavone-Chalcone Hybrids Exhibit Enhanced Antitumor Action through Modulating Redox Balance, Depolarizing the Mitochondrial Membrane, and Inhibiting ATR-Dependent Signaling. Antioxidants 9:6, pages 519.
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