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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 34, 2019 - Issue 1
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Original Article

Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition

Salwa ElmeligiePharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt;
,
Asmaa M. Aboul-MagdPharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University, Beni Suef, Egypt;
,
Deena S. LasheenPharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt;
,
Tamer M. IbrahimPharmaceutical Chemistry Department, Faculty of Pharmacy, Kafrelsheikh University, Kafr El-Sheikh, Egypt;
,
Tamer M. AbdelghanyPharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt;
,
Sohair M. KhojahBiochemistry Department, Faculty of science, King Abdulaziz University, Jedda, Kingdom of Saudi Arabia;
&
Khaled A. M. AbouzidPharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt; ;Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Sadat City, EgyptCorrespondence[email protected] [email protected]
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Pages 1347-1367 | Received 01 Apr 2019, Accepted 30 Jun 2019, Published online: 19 Jul 2019

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Raju Samala, Satheesh Kumar Nukala, Narasimha Swamy Thirukovela, Gouthami Dasari & Srinivas Bandari. (2023) One-Pot Synthesis of Some New Phthalazine-Piperazine-1,2,4-Oxadiazole Hybrids: Anticancer Evaluation, Molecular Docking and ADMET Studies. Polycyclic Aromatic Compounds 43:10, pages 9175-9192.
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Articles from other publishers (22)

Emilio Guillén-Mancina, María del Rosario García-Lozano, Estefanía Burgos-Morón, Sarah Mazzotta, Pablo Martínez-Aguado, José Manuel Calderón-Montaño, José Manuel Vega-Pérez, Miguel López-Lázaro, Fernando Iglesias-Guerra & Margarita Vega-Holm. (2023) Repurposing Study of 4-Acyl-1-phenylaminocarbonyl-2-substituted-piperazine Derivatives as Potential Anticancer Agents—In Vitro Evaluation against Breast Cancer Cells. International Journal of Molecular Sciences 24:23, pages 17041.
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Nitin Srivastava & Anil Kumar Saxena. (2023) Caspase-3 Activators as Anticancer Agents. Current Protein & Peptide Science 24:10, pages 783-804.
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Ramadan Ahmed Mekheimer, Mohamed Abd-Elmonem, Mohamed Abou Elsebaa, Maiiada Hassan Nazmy & Kamal Usef Sadek. (2023) Recent developments in the green synthesis of biologically relevant cinnolines and phthalazines. Physical Sciences Reviews 8:10, pages 3183-3267.
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Qingling Chen, Zhuoying Chen, Feilong Li, Haoyu Zha, Wei He, Fei Jiang, Jiamu Wei, Jiajia Xu, Rong Li, Li Cai & Xuesong Liu. (2023) Discovery of highly potent and selective VEGFR2 kinase inhibitors for the treatment of rheumatoid arthritis. European Journal of Medicinal Chemistry 257, pages 115456.
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Sara M. Emam, Samir M. El Rayes, Ibrahim A. I. Ali, Hamdy A. Soliman & Mohamed S. Nafie. (2023) Synthesis of phthalazine-based derivatives as selective anti-breast cancer agents through EGFR-mediated apoptosis: in vitro and in silico studies. BMC Chemistry 17:1.
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Yu‐Feng Liu, Cui Li & Guo‐Ping Yang. (2023) Synthesis of Heterocycles from 2‐Acylbenzoic Acids. European Journal of Organic Chemistry 26:27.
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U. Boda, V. Guguloth, S. Mood & H. Guguloth. (2023) Copper(I)-Catalyzed Regioselective Synthesis of 1,2,3-Triazole–Phthalazine-1,4-dione Hybrids, and Their Anticancer and Molecular Docking Studies. Russian Journal of Organic Chemistry 59:6, pages 1064-1070.
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Vinitha Badithapuram, Satheesh Kumar Nukala, Gouthami Dasari, Narasimha Swamy Thirukovela & Srinivas Bandari. (2023) Synthesis of Some New Phthalazine−piperazine−pyrazole Conjugates; In vitro Anti‐Cancer, ADMET And Molecular Docking Studies. ChemistrySelect 8:10.
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Vishakha S., Kumari Kajal, Sitanshu Mondal, Simranpreet K. Wahan, Balak Das Kurmi, Ghanshyam Das Gupta & Preeti Patel. (2023) Novel VEGFR‐2 Kinase Inhibitors as Anticancer Agents: A Review Focusing on SAR and Molecular Docking Studies (2016–2021). Chemistry & Biodiversity 20:2.
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Iman A. Y. Ghannam, Ahmed M. El Kerdawy, Marwa M. Mounier, Mahmoud T. Abo‐elfadl & Islam H. Ali. (2022) Novel 2‐oxo‐2‐phenylethoxy and benzyloxy diaryl urea hybrids as VEGFR‐2 inhibitors: Design, synthesis, and anticancer evaluation. Archiv der Pharmazie 356:2.
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Mohanreddy Pothireddy, Gurupada Hazra, Penke Vijaya Babu, Barla Thirupathi & Rambabu Dandela. (2022) Synthesis of Fluorinated 2-Benzylphthalazin-1(2H)-one, 1-Phthalazinamine, and 1-Alkoxy/Benzyloxyphthalazine Derivatives by an Ultrasonication Method. Synlett 33:17, pages 1716-1722.
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Dyhia Amrane, Omar Khoumeri, Patrice Vanelle & Nicolas Primas. (2022) Dichloro{4-(4-chlorophenoxy)phthalazin-1-yl} methylphosphonic dichloride. Molbank 2022:3, pages M1439.
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Samir M. El Rayes, Gaber El Enany, Ibrahim A. I. Ali, Wessam Ibrahim & Mohamed S. Nafie. (2022) Synthesis of Novel Phthalazinedione-Based Derivatives with Promising Cytotoxic, Anti-bacterial, and Molecular Docking Studies as VEGFR2 Inhibitors. ACS Omega 7:30, pages 26800-26811.
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Jinlei Wang, Weijun Xu, Junmin Qian, Yaping Wang, Guanghui Hou & Aili Suo. (2022) Photo-crosslinked hyaluronic acid hydrogel as a biomimic extracellular matrix to recapitulate in vivo features of breast cancer cells. Colloids and Surfaces B: Biointerfaces 209, pages 112159.
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Fathalla Khedr, Mohamed‐Kamal Ibrahim, Ibrahim H. Eissa, Hamada S. Abulkhair & Khaled El‐Adl. (2021) Phthalazine‐based VEGFR‐2 inhibitors: Rationale, design, synthesis, in silico, ADMET profile, docking, and anticancer evaluations. Archiv der Pharmazie 354:11.
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Sameh A. Rizk, Maher A. El-Hashash, Amr A. Youssef & Abdelfattah T. Elgendy. (2021) A green microwave method for synthesizing a more stable phthalazin-1-ol isomer as a good anticancer reagent using chemical plasma organic reactions. Heliyon 7:3, pages e06220.
Crossref
Ru Wang, Hu Liu, Yuan-Yuan You, Xin-Yu Wang, Bing-Bing Lv, Li-Qin Cao, Jia-Yu Xue, Yun-Gen Xu & Lei Shi. (2021) Discovery of novel VEGFR-2 inhibitors embedding 6,7-dimethoxyquinazoline and diarylamide fragments. Bioorganic & Medicinal Chemistry Letters 36, pages 127788.
Crossref
Zhang-Xu He, Yun-Peng Gong, Xin Zhang, Li-Ying Ma & Wen Zhao. (2021) Pyridazine as a privileged structure: An updated review on anticancer activity of pyridazine containing bioactive molecules. European Journal of Medicinal Chemistry 209, pages 112946.
Crossref
Sumera Zaib & Imtiaz Khan. (2020) Synthetic and medicinal chemistry of phthalazines: Recent developments, opportunities and challenges. Bioorganic Chemistry 105, pages 104425.
Crossref
Mohamed T.M. Nemr & Asmaa M. AboulMagd. (2020) New fused pyrimidine derivatives with anticancer activity: Synthesis, topoisomerase II inhibition, apoptotic inducing activity and molecular modeling study. Bioorganic Chemistry 103, pages 104134.
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Abdallah Turky, Ashraf H. Bayoumi, Adel Ghiaty, Adel S. El-Azab, Alaa A.-M. Abdel-Aziz & Hamada S. Abulkhair. (2020) Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects. Bioorganic Chemistry 101, pages 104019.
Crossref
Hamada S. Abulkhair, Abdallah Turky, Adel Ghiaty, Hany E.A. Ahmed & Ashraf H. Bayoumi. (2020) Novel triazolophthalazine-hydrazone hybrids as potential PCAF inhibitors: Design, synthesis, in vitro anticancer evaluation, apoptosis, and molecular docking studies. Bioorganic Chemistry 100, pages 103899.
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