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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 34, 2019 - Issue 1
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Research Paper

Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamides as carbonic anhydrase isoforms I and II inhibitors

Mohammad M. Al-SaneaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia; Correspondence[email protected]@gmail.com
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Ahmed ElkamhawyChemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea; ;Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; ORCID Iconhttp://orcid.org/0000-0001-7398-6155View further author information
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Sora PaikChemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea; View further author information
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Silvia BuaDepartment of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy; View further author information
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So Ha LeeChemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea; View further author information
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Mohamed A. AbdelgawadDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia; ;Department of Pharmaceutical Organic Chemistry, Beni-Suef University, Beni-Suef, Egypt; View further author information
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Eun Joo RohChemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea; ;Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea; View further author information
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Wagdy M. EldehnaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, EgyptView further author information
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Claudiu T. SupuranDepartment of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-4262-0323View further author information
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Pages 1457-1464 | Received 04 Jul 2019, Accepted 31 Jul 2019, Published online: 14 Aug 2019

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Waleed A. Badawi, Mahmoud Rashed, Alessio Nocentini, Alessandro Bonardi, Mohammad M. Abd-Alhaseeb, Sara T. Al-Rashood, Giri Babu Veerakanellore, Taghreed A. Majrashi, Eslam B. Elkaeed, Bahaa Elgendy, Paola Gratteri, Claudiu T. Supuran, Wagdy M. Eldehna & Mohamed Elagawany. (2023) Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Amany Belal, Nagwa M. Abdel Gawad, Ahmed B. M. Mehany, Mohammed A. S. Abourehab, Hazem Elkady, Ahmed A. Al‐Karmalawy & Ahmed S. Ismael. (2022) Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1884-1902.
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Mohamed M. Khalifa, Ahmed A. Al-Karmalawy, Eslam B. Elkaeed, Mohamed S. Nafie, Mohamed A. Tantawy, Ibrahim H. Eissa & Hazem A. Mahdy. (2022) Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo studies. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 299-314.
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Aleksandrs Pustenko, Alessio Nocentini, Paola Gratteri, Alessandro Bonardi, Igor Vozny, Raivis Žalubovskis & Claudiu T. Supuran. (2020) The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1011-1020.
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Mohamed A. Abdelrahman, Wagdy M. Eldehna, Alessio Nocentini, Hany S. Ibrahim, Hadia Almahli, Hatem A. Abdel-Aziz, Sahar M. Abou-Seri & Claudiu T. Supuran. (2020) Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 298-305.
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Mahmoud A. Ragab, Wagdy M. Eldehna, Alessio Nocentini, Alessandro Bonardi, Hazem E. Okda, Bahaa Elgendy, Tarek S. Ibrahim, Mohammad M. Abd-Alhaseeb, Paola Gratteri, Claudiu T. Supuran, Ahmed A. Al-Karmalawy & Mohamed Elagawany. (2023) 4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments. European Journal of Medicinal Chemistry 250, pages 115180.
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Reihane Ghomashi, Shakila Ghomashi, Hamidreza Aghaei & Ahmad Reza Massah. (2023) Recent Advances in Biological Active Sulfonamide based Hybrid Compounds Part A: Two-Component Sulfonamide Hybrids. Current Medicinal Chemistry 30:4, pages 407-480.
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Afaf El-Malah, Ehab S. Taher, Andrea Angeli, Samar S. Elbaramawi, Zeinab Mahmoud, Nour Moustafa, Claudiu T. Supuran & Tarek S. Ibrahim. (2023) Schiff bases as linker in the development of quinoline-sulfonamide hybrids as selective cancer-associated carbonic anhydrase isoforms IX/XII inhibitors: A new regioisomerism tactic. Bioorganic Chemistry 131, pages 106309.
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Samar A. El-Kalyoubi, Ehab S. Taher, Tarek S. Ibrahim, Mohammed Farrag El-Behairy & Amany M. M. Al-Mahmoudy. (2022) Uracil as a Zn-Binding Bioisostere of the Allergic Benzenesulfonamide in the Design of Quinoline–Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors. Pharmaceuticals 15:5, pages 494.
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Mostafa M. Elbadawi, Wagdy M. Eldehna, Wenjie Wang, Keli K. Agama, Yves Pommier & Manabu Abe. (2021) Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity. European Journal of Medicinal Chemistry 215, pages 113261.
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Mohammad M. Al-Sanea, Ahmad J. Obaidullah, Mohamed E. Shaker, Garri Chilingaryan, Mohammed M. Alanazi, Nawaf A. Alsaif, Hamad M. Alkahtani, Sultan A. Alsubaie & Mohamed A. Abdelgawad. (2021) A New CDK2 Inhibitor with 3-Hydrazonoindolin-2-One Scaffold Endowed with Anti-Breast Cancer Activity: Design, Synthesis, Biological Evaluation, and In Silico Insights. Molecules 26:2, pages 412.
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Mohammad M. Al-Sanea, Ahmed Elkamhawy, Sora Paik, Kyeong Lee, Ahmed M. El Kerdawy, Bukhari Syed Nasir Abbas, Eun Joo Roh, Wagdy M. Eldehna, Heba A.H. Elshemy, Rania B Bakr, Ibrahim Ali Farahat, Abdulaziz I. Alzarea, Sami I. Alzarea, Khalid S. Alharbi & Mohamed A. Abdelgawad. (2020) Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights. Bioorganic & Medicinal Chemistry 28:13, pages 115525.
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Mohammad M. Al-Sanea. (2020) Synthesis and biological evaluation of small molecule modulators of CDK8/Cyclin C complex with phenylaminoquinoline scaffold. PeerJ 8, pages e8649.
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Mohamed A. Said, Wagdy M. Eldehna, Alessio Nocentini, Samar H. Fahim, Alessandro Bonardi, Abdullah A. Elgazar, Vladimír Kryštof, Dalia H. Soliman, Hatem A. Abdel-Aziz, Paola Gratteri, Sahar M. Abou-Seri & Claudiu T. Supuran. (2020) Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation. European Journal of Medicinal Chemistry 189, pages 112019.
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