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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Research Paper

A structure-based approach towards the identification of novel antichagasic compounds: Trypanosoma cruzi carbonic anhydrase inhibitors

Manuel A. Llanosa Laboratory of Bioactive Research and Development (LIDeB), Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, Buenos Aires, ArgentinaView further author information
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María L. Sbaraglinia Laboratory of Bioactive Research and Development (LIDeB), Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, Buenos Aires, ArgentinaView further author information
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María L. Villalbaa Laboratory of Bioactive Research and Development (LIDeB), Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, Buenos Aires, ArgentinaView further author information
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María D. Ruizb Instituto de Ciencias y Tecnología Dr. Cesar Milstein (ICT Milstein), Argentinean National Council of Scientific and Technical Research (CONICET), Buenos Aires, ArgentinaView further author information
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Carolina Carrillob Instituto de Ciencias y Tecnología Dr. Cesar Milstein (ICT Milstein), Argentinean National Council of Scientific and Technical Research (CONICET), Buenos Aires, ArgentinaView further author information
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Catalina Alba Sotoc Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM), UBA-CONICET, Buenos Aires, ArgentinaView further author information
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Alan Talevia Laboratory of Bioactive Research and Development (LIDeB), Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, Buenos Aires, ArgentinaView further author information
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Andrea Angelid Neurofarba Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Universita degli Studi di Firenze, Sesto Fiorentino, Florence, ItalyORCID Iconhttps://orcid.org/0000-0002-1470-7192View further author information
ORCID Icon,
Seppo Parkkilae Faculty of Medicine and Health Technology, University of Tampere, Tampere, FinlandView further author information
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Claudiu T. Supurand Neurofarba Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Universita degli Studi di Firenze, Sesto Fiorentino, Florence, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4262-0323View further author information
ORCID Icon &
Luciana Gaverneta Laboratory of Bioactive Research and Development (LIDeB), Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, Buenos Aires, ArgentinaCorrespondence[email protected]
View further author information
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Pages 21-30 | Received 09 Sep 2019, Accepted 01 Oct 2019, Published online: 16 Oct 2019

Citations (11)

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Read on this site (4)

Alessandro Bonardi, Seppo Parkkila & Claudiu T. Supuran. (2022) Inhibition studies of the protozoan α-carbonic anhydrase from Trypanosoma cruzi with phenols. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2417-2422.
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Andrea Angeli, Marta Ferraroni, Fabrizio Carta, Cécile Häberli, Jennifer Keiser, Gabriele Costantino & Claudiu T. Supuran. (2022) Development of Praziquantel sulphonamide derivatives as antischistosomal drugs. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1479-1494.
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Alane Beatriz Vermelho, Giseli Capaci Rodrigues, Alessio Nocentini, Felipe R. P. Mansoldo & Claudiu T. Supuran. (2022) Discovery of novel drugs for Chagas disease: is carbonic anhydrase a target for antiprotozoal drugs?. Expert Opinion on Drug Discovery 17:10, pages 1147-1158.
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Claudiu T. Supuran. (2020) Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery. Expert Opinion on Drug Discovery 15:6, pages 671-686.
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Articles from other publishers (7)

Manuel A. Llanos, Lucas N. Alberca, María D. Ruiz, María L. Sbaraglini, Cristian Miranda, Agustina Pino-Martinez, Laura Fraccaroli, Carolina Carrillo, Catalina D. Alba Soto, Luciana Gavernet & Alan Talevi. (2022) A combined ligand and target-based virtual screening strategy to repurpose drugs as putrescine uptake inhibitors with trypanocidal activity. Journal of Computer-Aided Molecular Design 37:2, pages 75-90.
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Manuel A. Llanos, Lucas N. Alberca, Salomé C. Vilchez Larrea, Alejandra C. Schoijet, Guillermo D. Alonso, Carolina L. Bellera, Luciana Gavenet & Alan Talevi. (2021) Homology Modeling and Molecular Dynamics Simulations of Trypanosoma cruzi Phosphodiesterase b1 . Chemistry & Biodiversity 19:1.
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Pınar Güller, Ziya Dağalan, Uğur Güller, Ulaş Çalışır & Bilal Nişancı. (2021) Enzymes inhibition profiles and antibacterial activities of benzylidenemalononitrile derivatives. Journal of Molecular Structure 1239, pages 130498.
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Alessio Nocentini, Alane B. Vermelho & Claudiu T. Supuran. 2022. Antiprotozoal Drug Development and Delivery. Antiprotozoal Drug Development and Delivery 83 111 .
Felipe Raposo Passos Mansoldo, Fabrizio Carta, Andrea Angeli, Veronica da Silva Cardoso, Claudiu T. Supuran & Alane Beatriz Vermelho. (2020) Chagas Disease: Perspectives on the Past and Present and Challenges in Drug Discovery. Molecules 25:22, pages 5483.
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Claudio A. Pereira, Melisa Sayé, Chantal Reigada, Ariel M. Silber, Guillermo R. Labadie, Mariana R. Miranda & Edward Valera-Vera. (2020) Computational approaches for drug discovery against trypanosomatid-caused diseases. Parasitology 147:6, pages 611-633.
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Andrea Angeli, Mariana Pinteala, Stelian S. Maier, Bogdan C. Simionescu, Akram A. Da’dara, Patrick J. Skelly & Claudiu T. Supuran. (2020) Sulfonamide Inhibition Studies of an α-Carbonic Anhydrase from Schistosoma mansoni, a Platyhelminth Parasite Responsible for Schistosomiasis. International Journal of Molecular Sciences 21:5, pages 1842.
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