3,954
Views
15
CrossRef citations to date
0
Altmetric
Research Paper

Identification of novel CDK2 inhibitors by a multistage virtual screening method based on SVM, pharmacophore and docking model

, , , , &
Pages 235-244 | Received 06 Aug 2019, Accepted 10 Nov 2019, Published online: 25 Nov 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Garima Kumari, Vinod Kumar Nigam & Dev Mani Pandey. (2023) Mutational analysis of flavonol synthase of M. pinnata towards enhancement of binding affinity: a computational approach. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-14.
Read now
Garima Kumari, Vinod Kumar Nigam & Dev Mani Pandey. (2023) The molecular docking and molecular dynamics study of flavonol synthase and flavonoid 3’-monooxygenase enzymes involved for the enrichment of kaempferol. Journal of Biomolecular Structure and Dynamics 41:6, pages 2478-2491.
Read now
Ahmed M. Shawky, Nashwa A. Ibrahim, Mohammed A. S. Abourehab, Ashraf N. Abdalla & Ahmed M. Gouda. (2021) Pharmacophore-based virtual screening, synthesis, biological evaluation, and molecular docking study of novel pyrrolizines bearing urea/thiourea moieties with potential cytotoxicity and CDK inhibitory activities. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 15-33.
Read now

Articles from other publishers (12)

Monica Ramasamy, Aishwarya Vetrivel, Sharulatha Venugopal & Rajeswari Murugesan. (2023) Identification of inhibitors for Agr quorum sensing system of Staphylococcus aureus by machine learning, pharmacophore modeling, and molecular dynamics approaches. Journal of Molecular Modeling 29:8.
Crossref
Haozhen Wang, Ziyin Lu, Yang Li, Ting Liu, Linlin Zhao, Tianqi Gao, Xiuli Lu & Bing Gao. (2023) Virtual Screening of Novel 24-Dehydroxysterol Reductase (DHCR24) Inhibitors and the Biological Evaluation of Irbesartan in Cholesterol-Lowering Effect. Molecules 28:6, pages 2643.
Crossref
YOUSEF SABAH ALI, MONTHER FAISAL MAHDI & BASMA M. ABD RAZIK. (2023) IN SILICO EVALUATION OF BINDING INTERACTION AND ADME PROPERTIES OF NOVEL 5-(THIOPHEN-2-YL)-1,3,4-OXADIAZOLE-2-AMINE DERIVATIVES AS ANTI-PROLIFERATIVE AGENTS. International Journal of Applied Pharmaceutics, pages 141-146.
Crossref
Anthony Cheung, Alicia M. Chenoweth, Jelmar Quist, Heng Sheng Sow, Christina Malaktou, Riccardo Ferro, Ricarda M. Hoffmann, Gabriel Osborn, Eirini Sachouli, Elise French, Rebecca Marlow, Katie E. Lacy, Sophie Papa, Anita Grigoriadis & Sophia N. Karagiannis. (2022) CDK Inhibition Primes for Anti-PD-L1 Treatment in Triple-Negative Breast Cancer Models. Cancers 14:14, pages 3361.
Crossref
Na Zhai, Yanming Chen, Chenchen Wang, Fengshou Wu, Xiaogang Luo, Xiulian Ju, Hui Liu & Genyan Liu. (2022) A multiscale screening strategy for the identification of novel xanthine oxidase inhibitors based on the pharmacological features of febuxostat analogues. New Journal of Chemistry 46:14, pages 6549-6559.
Crossref
Rania Helmy Abd El-Hameed, Samar Said Fatahala & Amira Ibrahim Sayed. (2022) Synthesis of Some Novel Benzimidazole Derivatives as Anticancer Agent and Evaluation for CDK2 Inhibition Activity. Medicinal Chemistry 18:2, pages 238-248.
Crossref
Andrea Basciu, Lara Callea, Stefano Motta, Alexandre M.J.J. Bonvin, Laura Bonati & Attilio V. Vargiu. 2022. Virtual Screening and Drug Docking. Virtual Screening and Drug Docking 43 97 .
Samar S. Fatahala, Amira I. Sayed, Shahenda Mahgoub, Heba Taha, Mohamed-I kotb El-Sayed, Mohamed F. El-Shehry, Samir M. Awad & Rania H. Abd El-Hameed. (2021) Synthesis of Novel 2-Thiouracil-5-Sulfonamide Derivatives as Potent Inducers of Cell Cycle Arrest and CDK2A Inhibition Supported by Molecular Docking. International Journal of Molecular Sciences 22:21, pages 11957.
Crossref
Hani Z. Asfour, Nabil A. Alhakamy, Khalid Eljaaly, Ahmed L. Alaofi, Mohamed A. Tantawy, Khulood S. Hussein, Ahmed A. Aldarmahi & Mahmoud A. Elfaky. (2021) Molecular docking studies of HIV TAT and sitagliptin nano-formula as potential therapeutic targeting SARS-CoV2 protease. Journal of the Indian Chemical Society 98:9, pages 100119.
Crossref
Jitendra Kuldeep, Sandeep K. Sharma, Tanuj Sharma, Bhupendra N. Singh & Mohammad Imran Siddiqi. (2020) Targeting Mycobacterium Tuberculosis Enoyl‐Acyl Carrier Protein Reductase Using Computational Tools for Identification of Potential Inhibitor and their Biological Activity. Molecular Informatics 40:5.
Crossref
Javier Vázquez, Manel López, Enric Gibert, Enric Herrero & F. Javier Luque. (2020) Merging Ligand-Based and Structure-Based Methods in Drug Discovery: An Overview of Combined Virtual Screening Approaches. Molecules 25:20, pages 4723.
Crossref
Rameez Hassan Pirzada, Nasir Javaid & Sangdun Choi. (2020) The Roles of the NLRP3 Inflammasome in Neurodegenerative and Metabolic Diseases and in Relevant Advanced Therapeutic Interventions. Genes 11:2, pages 131.
Crossref