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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Research Paper

Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3

Paula Martínez de Iturratea Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, SpainView further author information
,
Victor Sebastián-Péreza Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, SpainORCID Iconhttps://orcid.org/0000-0002-8248-4496View further author information
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Montserrat Nácher-Vázqueza Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, SpainView further author information
,
Catherine S. Trempera Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, SpainView further author information
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Despina Smirlisb Microbiology Department, Hellenic Pasteur Institute, Athens, GreeceORCID Iconhttps://orcid.org/0000-0003-4996-2879View further author information
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Julio Martínc Global Health R&D, GlaxoSmithKline, Tres Cantos, SpainView further author information
,
Ana Martíneza Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, SpainORCID Iconhttps://orcid.org/0000-0002-2707-8110View further author information
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Nuria E. Campilloa Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, SpainORCID Iconhttps://orcid.org/0000-0002-9948-2665View further author information
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Luis Rivasa Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, SpainCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2958-3233View further author information
ORCID Icon &
Carmen Gila Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, SpainCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3882-6081View further author information
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Pages 199-210 | Received 25 Sep 2019, Accepted 10 Nov 2019, Published online: 22 Nov 2019

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Praveen Rai, Hemant Arya, Satabdi Saha, Diwakar Kumar & Tarun Kumar Bhatt. (2022) Drug repurposing based novel anti-leishmanial drug screening using in-silico and in-vitro approaches. Journal of Biomolecular Structure and Dynamics 40:21, pages 10812-10820.
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Articles from other publishers (9)

Ahmed H.E. Hassan, Mohammad Maqusood Alam, Trong-Nhat Phan, Kyung-Hwa Baek, Hyeryon Lee, Soo Bin Cho, Chae Hyeon Lee, Yeon Ju Kim, Joo Hwan No & Yong Sup Lee. (2023) Repurposing of conformationally-restricted cyclopentane-based AKT–inhibitors leads to discovery of potential and more selective antileishmanial agents than miltefosine. Bioorganic Chemistry 141, pages 106890.
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Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Nícolas Peterson Ferreira Brito, Daniela de Melo Resende, Felipe de Oliveira Souza, Eduardo Jorge Pilau, Meryck Felipe Brito da Silva, Bruno Junior Neves, Silvane Maria Fonseca Murta & Celso de Oliveira Rezende Júnior. (2023) Hit-to-lead optimization of a pyrazinylpiperazine series against Leishmania infantum and Leishmania braziliensis. European Journal of Medicinal Chemistry 256, pages 115445.
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Yasmim Mendes Rocha, Emanuel Paula Magalhães, Marlos de Medeiros Chaves, Márcia Machado Marinho, Valentina Nascimento e Melo de Oliveira, Ronaldo Nascimento de Oliveira, Tiago Lima Sampaio, Ramon R. P. P. B. de Menezes, Alice M. C. Martins & Roberto Nicolete. (2022) Antiparasitary and antiproliferative activities in vitro of a 1,2,4-oxadiazole derivative on Trypanosoma cruzi. Parasitology Research 121:7, pages 2141-2156.
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Victor Sebastián-Pérez, Paula Martínez de Iturrate, Montserrat Nácher-Vázquez, Luis Nóvoa, Concepción Pérez, Nuria E. Campillo, Carmen Gil & Luis Rivas. (2022) Naphthoquinone as a New Chemical Scaffold for Leishmanicidal Inhibitors of Leishmania GSK-3. Biomedicines 10:5, pages 1136.
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Matteo Santucci, Rosaria Luciani, Eleonora Gianquinto, Cecilia Pozzi, Flavio di Pisa, Lucia dello Iacono, Giacomo Landi, Lorenzo Tagliazucchi, Stefano Mangani, Francesca Spyrakis & Maria Paola Costi. (2021) Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases. Pharmaceuticals 14:12, pages 1246.
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Payel Das, Saradindu Saha & Somdeb BoseDasgupta. (2021) The ultimate fate determinants of drug induced cell-death mechanisms in Trypanosomatids. International Journal for Parasitology: Drugs and Drug Resistance 15, pages 81-91.
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Antonia Efstathiou & Despina Smirlis. (2021) Leishmania Protein Kinases: Important Regulators of the Parasite Life Cycle and Molecular Targets for Treating Leishmaniasis. Microorganisms 9:4, pages 691.
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N. Baker, C. M. C. Catta-Preta, R. Neish, J. Sadlova, B. Powell, E. V. C. Alves-Ferreira, V. Geoghegan, J. B. T. Carnielli, K. Newling, C. Hughes, B. Vojtkova, J. Anand, A. Mihut, P. B. Walrad, L. G. Wilson, J. W. Pitchford, P. Volf & J. C. Mottram. (2021) Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival. Nature Communications 12:1.
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Susiany P. Lopes, Lina M. Yepes, Yunierkis Pérez-Castillo, Sara M. Robledo & Damião P. de Sousa. (2020) Alkyl and Aryl Derivatives Based on p-Coumaric Acid Modification and Inhibitory Action against Leishmania braziliensis and Plasmodium falciparum. Molecules 25:14, pages 3178.
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