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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Research Paper

Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation

Mohamed A. Abdelrahmana Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Egypt
,
Wagdy M. Eldehnab Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, EgyptCorrespondence[email protected]
,
Alessio Nocentinic Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy
,
Hany S. Ibrahima Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Egypt
,
Hadia Almahlid Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK
,
Hatem A. Abdel-Azize Department of Applied Organic Chemistry, National Research Center, Dokki, Egypt
,
Sahar M. Abou-Serif Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, EgyptCorrespondence[email protected]
&
Claudiu T. Supuranc Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4262-0323
ORCID Icon show all
Pages 298-305 | Received 27 Oct 2019, Accepted 18 Nov 2019, Published online: 06 Dec 2019

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Mahmoud F. Abo-Ashour, Hadia Almahli, Alessandro Bonardi, Amira Khalil, Tarfah Al-Warhi, Sara T. Al-Rashood, Hatem A. Abdel-Aziz, Alessio Nocentini, Claudiu T. Supuran & Wagdy M. Eldehna. (2022) Enaminone-based carboxylic acids as novel non-classical carbonic anhydrases inhibitors: design, synthesis and in vitro biological assessment. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2256-2264.
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Mateusz Kciuk, Adrianna Gielecińska, Somdutt Mujwar, Mariusz Mojzych, Beata Marciniak, Rafał Drozda & Renata Kontek. (2022) Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1278-1298.
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Wagdy M. Eldehna, Mohammed S. Taghour, Tarfah Al-Warhi, Alessio Nocentini, Mostafa M. Elbadawi, Hazem A. Mahdy, Mohamed A. Abdelrahman, Ohoud J. Alotaibi, Nada Aljaeed, Diaaeldin M. Elimam, Kamyar Afarinkia, Hatem A. Abdel-Aziz & Claudiu T. Supuran. (2022) Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 531-541.
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Mohammad M. Al-Sanea, Ghada H. Al-Ansary, Zainab M. Elsayed, Raed M. Maklad, Eslam B. Elkaeed, Mohamed A. Abdelgawad, Syed Nasir Abbas Bukhari, Marwa M. Abdel-Aziz, Howayda Suliman & Wagdy M. Eldehna. (2021) Development of 3-methyl/3-(morpholinomethyl)benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cells. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 987-999.
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Articles from other publishers (11)

Ashraf A. Abbas & Kamal M. Dawood. (2023) Anticancer therapeutic potential of benzofuran scaffolds. RSC Advances 13:16, pages 11096-11120.
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Shakila Ghomashi, Reihane Ghomashi, Hamidreza Aghaei & Ahmad Reza Massah. (2023) Recent Advances in Biological Active Sulfonamide based Hybrid Compounds Part B: Two-Component Sulfonamide Hybrids. Current Medicinal Chemistry 30:5, pages 604-665.
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Amit Kumar, Kiran Siwach, Claudiu T. Supuran & Pawan K. Sharma. (2022) A decade of tail-approach based design of selective as well as potent tumor associated carbonic anhydrase inhibitors. Bioorganic Chemistry 126, pages 105920.
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Hany S. Ibrahim, Mohamed A. Abdelrahman, Alessio Nocentini, Silvia Bua, Hatem A. Abdel-Aziz, Claudiu T. Supuran, Sahar M. Abou-Seri & Wagdy M. Eldehna. (2022) Insights into the effect of elaborating coumarin-based aryl enaminones with sulfonamide or carboxylic acid functionality on carbonic anhydrase inhibitory potency and selectivity. Bioorganic Chemistry 126, pages 105888.
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Haytham O. Tawfik, Andrea Petreni, Claudiu T. Supuran & Mervat H. El-Hamamsy. (2022) Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach. European Journal of Medicinal Chemistry 232, pages 114190.
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Diaaeldin M. Elimam, Wagdy M. Eldehna, Rofaida Salem, Alessandro Bonardi, Alessio Nocentini, Sara T. Al-Rashood, Mahmoud M. Elaasser, Paola Gratteri, Claudiu T. Supuran & Heba Abdelrasheed Allam. (2022) Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors. European Journal of Medicinal Chemistry 228, pages 114008.
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Mohammad M. Al-Sanea, Garri Chilingaryan, Narek Abelyan, Grigor Arakelov, Harutyun Sahakyan, Vahram G. Arakelov, Karen Nazaryan, Shaimaa Hussein, Gharam M. Alazmi, Haifa E. Alsharari, Waad M. Al-faraj, Faten S. Alruwaili, Nouf Q. Albilasi, Tahani S. Alsharari, Abdulaziz A. S. Alsaleh, Turki M. Alazmi, Atiah H. Almalki, Nasser H. Alotaibi & Mohamed A. Abdelgawad. (2021) Identification of non-classical hCA XII inhibitors using combination of computational approaches for drug design and discovery. Scientific Reports 11:1.
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Moataz Shaldam, Wagdy M. Eldehna, Alessio Nocentini, Zainab M. Elsayed, Tamer M. Ibrahim, Rofaida Salem, Ramadan A. El-Domany, Clemente Capasso, Hatem A. Abdel-Aziz & Claudiu T. Supuran. (2021) Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors. European Journal of Medicinal Chemistry 216, pages 113283.
Crossref
Simone Carradori & Claudiu T. Supuran. 2021. pH-Interfering Agents as Chemosensitizers in Cancer Therapy. pH-Interfering Agents as Chemosensitizers in Cancer Therapy 79 94 .
A‐Liang Li, Ya‐Qun Yang, Wen‐Yan Wang, Qing‐Song Liu, Yue Sun & Wen Gu. (2020) Synthesis, cytotoxicity and apoptosis‐inducing activity of novel 1 H ‐benzo[ d ]imidazole derivatives of dehydroabietic acid . Journal of the Chinese Chemical Society 67:9, pages 1668-1678.
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Wagdy M. Eldehna, Alessio Nocentini, Zainab M. Elsayed, Tarfah Al-Warhi, Nada Aljaeed, Ohoud J. Alotaibi, Mohammad M. Al-Sanea, Hatem A. Abdel-Aziz & Claudiu T. Supuran. (2020) Benzofuran-Based Carboxylic Acids as Carbonic Anhydrase Inhibitors and Antiproliferative Agents against Breast Cancer. ACS Medicinal Chemistry Letters 11:5, pages 1022-1027.
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