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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Short Communication

Novel CDKs inhibitors for the treatment of solid tumour by simultaneously regulating the cell cycle and transcription control

Xin Wanga Department of Medicinal Chemistry, School of Medicine, Nankai University, Tianjin, ChinaView further author information
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Kaiyuan Denga Department of Medicinal Chemistry, School of Medicine, Nankai University, Tianjin, ChinaView further author information
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Cheng Wanga Department of Medicinal Chemistry, School of Medicine, Nankai University, Tianjin, ChinaView further author information
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Yao Lia Department of Medicinal Chemistry, School of Medicine, Nankai University, Tianjin, ChinaView further author information
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Tianqi Wanga Department of Medicinal Chemistry, School of Medicine, Nankai University, Tianjin, ChinaView further author information
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Zhi Huanga Department of Medicinal Chemistry, School of Medicine, Nankai University, Tianjin, ChinaView further author information
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Yakun Maa Department of Medicinal Chemistry, School of Medicine, Nankai University, Tianjin, ChinaView further author information
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Peiqing Suna Department of Medicinal Chemistry, School of Medicine, Nankai University, Tianjin, China;e Department of Cancer Biology, Wake Forest Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC, USAView further author information
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Yi Shia Department of Medicinal Chemistry, School of Medicine, Nankai University, Tianjin, China;b 2011 Project Collaborative Innovation Center for Biotherapy of Ministry of Education, Tianjin, ChinaView further author information
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Shengyong Yangd Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaView further author information
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Yan Fana Department of Medicinal Chemistry, School of Medicine, Nankai University, Tianjin, China;b 2011 Project Collaborative Innovation Center for Biotherapy of Ministry of Education, Tianjin, ChinaCorrespondence[email protected]
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&
Rong Xianga Department of Medicinal Chemistry, School of Medicine, Nankai University, Tianjin, China;b 2011 Project Collaborative Innovation Center for Biotherapy of Ministry of Education, Tianjin, China;c State Key Laboratory of Medicinal Chemical Biology, Tianjin, ChinaCorrespondence[email protected]
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Pages 414-423 | Received 25 Sep 2019, Accepted 09 Dec 2019, Published online: 03 Jan 2020

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Lifei Wang, Dan Lu, Yan Wang, Xiaoyan Xu, Peihua Zhong & Zhiyong Yang. (2023) Binding selectivity-dependent molecular mechanism of inhibitors towards CDK2 and CDK6 investigated by multiple short molecular dynamics and free energy landscapes. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 84-99.
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Prosper Obed Chukwuemeka, Haruna Isiyaku Umar, Opeyemi Iwaloye, Oluwaseyi Matthew Oretade, Christopher Busayo Olowosoke, Oyeyemi Janet Oretade & Michael Omoniyi Elabiyi. (2022) Predictive hybrid paradigm for cytotoxic activity of 1,3,4-thiadiazole derivatives as CDK6 inhibitors against human (MCF-7) breast cancer cell line and its structural modifications: rational for novel cancer therapeutics. Journal of Biomolecular Structure and Dynamics 40:18, pages 8518-8537.
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Longyan Ran, Xiao Mou, Zhenglin Peng, Xiaochen Li, Meirong Li, Duo Xu, Zixi Yang, Xingwang Sun & Tao Yin. (2023) ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma. Scientific Reports 13:1.
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Mostafa GM El-Gazzar, Marwa G El-Gazzar & Mostafa M Ghorab. (2023) Quinazolinone derivatives as new potential CDK4/6 inhibitors, apoptosis inducers and radiosensitizers for breast cancer. Future Medicinal Chemistry.
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Xiaotian He, Yiyang Ma, Zirui Huang, Gongming Wang, Weidong Wang, Rusi Zhang, Guangran Guo, Xuewen Zhang, Yingsheng Wen & Lanjun Zhang. (2023) SERPINB5 is a prognostic biomarker and promotes proliferation, metastasis and epithelial‐mesenchymal transition ( EMT) in lung adenocarcinoma . Thoracic Cancer 14:23, pages 2275-2287.
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Huan He, Qi Liu, Lu Chen, Jie Wang, Yuan Yuan, Honglin Li, Xuhong Qian, Zhenjiang Zhao & Zhuo Chen. (2022) Design, synthesis and biological evaluation of pteridine-7(8H)-one derivatives as potent and selective CDK4/6 inhibitors. Bioorganic & Medicinal Chemistry Letters 76, pages 128991.
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Deendyal Bhurta & Sandip B. Bharate. (2021) Analyzing the scaffold diversity of cyclin‐dependent kinase inhibitors and revisiting the clinical and preclinical pipeline. Medicinal Research Reviews 42:2, pages 654-709.
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Haiying Zhang, Jianan Sun, Ruoting Ma & Shengjun Zhao. (2021) Role of Episamarcandin in Promoting the Apoptosis of Human Colon Cancer HCT116 Cells through the PI3K-Akt Signaling Pathway. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-12.
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Yong Yang, Guangda Yuan, Hongya Xie, Tengteng Wei, Donglin Zhu, Yimeng Zhu & Shiying Zheng. (2021) CDK14 expression is elevated in patients with non-small cell lung cancer and correlated with poor prognosis. Journal of International Medical Research 49:10, pages 030006052110131.
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Eclair Venturini Filho, Erick M.C. Pinheiro, Sergio Pinheiro & Sandro J. Greco. (2021) Aminopyrimidines: Recent synthetic procedures and anticancer activities. Tetrahedron 92, pages 132256.
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Xiquan Zhang, Qin Wang, Yijun Luo, Meijiao Song, Zhiyong Zhou, Lin Zeng, Meng Hu & Chuyan Yang. (2021) Cyclin-dependent kinase 15 upregulation is correlated with poor prognosis for patients with breast cancer. Journal of International Medical Research 49:6, pages 030006052199955.
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Mona O. Sarhan, Somaia S. Abd El-Karim, Manal M. Anwar, Raghda H. Gouda, Wafaa A. Zaghary & Mohammed A. Khedr. (2021) Discovery of New Coumarin-Based Lead with Potential Anticancer, CDK4 Inhibition and Selective Radiotheranostic Effect: Synthesis, 2D & 3D QSAR, Molecular Dynamics, In Vitro Cytotoxicity, Radioiodination, and Biodistribution Studies. Molecules 26:8, pages 2273.
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A Špičáková, P Kraus, T Gucký, V Kryštof, M Strnad, V Bazgier, M Otyepka, V Kubíčková, M Poruba, Z Rácová, I Zapletalová & P Anzenbacher. (2020) in vitro and in silico studies of interaction of synthetic 2,6,9-trisubstituted purine kinase inhibitors BPA-302, BP-21 and BP-117 with liver drug-metabolizing cytochromes P450. Physiological Research, pages S627-S636.
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Yan Fan, Zhi Huang, Xiaoshuang Wang, Yakun Ma, Yongtao Li, Shengyong Yang & Yi Shi. (2020) Discovery of 12O—A Novel Oral Multi-Kinase Inhibitor for the Treatment of Solid Tumor. Molecules 25:21, pages 5199.
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Hongyu Hu, Jun Wu, Mingtao Ao, Xiaoping Zhou, Boqun Li, Zhenzhen Cui, Tong Wu, Lijuan Wang, Yuhua Xue, Zhen Wu & Meijuan Fang. (2020) Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold: Novel potential CDK9 inhibitors. Bioorganic Chemistry 102, pages 104064.
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