2,594
Views
35
CrossRef citations to date
0
Altmetric
Research Paper

N-monoarylacetothioureas as potent urease inhibitors: synthesis, SAR, and biological evaluation

, , , , , , , , , , & show all
Pages 404-413 | Received 23 Aug 2019, Accepted 14 Dec 2019, Published online: 27 Dec 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Muhammad Taha, Fazal Rahim, Imad Uddin, Mohd Amir, Naveed Iqbal, Abdul Wadood, Khalid Mohammed Khan, Nizam Uddin, Ashfaq Ur Rehman & Rai Khalid Farooq. (2023) Discovering phenoxy acetohydrazide derivatives as urease inhibitors and molecular docking studies. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-10.
Read now

Articles from other publishers (34)

Yousaf Khan, Shoaib Khan, Rafaqat Hussain, Aneela Maalik, Wajid Rehman, Mohamed W. Attwa, Rafia Masood, Hany W. Darwish & Hazem A. Ghabbour. (2023) The Synthesis, In Vitro Bio-Evaluation, and In Silico Molecular Docking Studies of Pyrazoline–Thiazole Hybrid Analogues as Promising Anti-α-Glucosidase and Anti-Urease Agents. Pharmaceuticals 16:12, pages 1650.
Crossref
Atteeque Ahmed, Aftab Ahmed, Pervaiz Ali Channar, Syeda Abida Ejaz, Aisha A. Alsfouk, Aamer Saeed, Rabail Ujan, Qamar Abbas, Tuncer Hökelek & Michael Bolte. (2023) Synthesis, Single Crystal XRD, In-Silico and In-Vitro Studies of Alkyl Substituted Acyl Thiourea as Carbonic Anhydrase Inhibitor. Journal of Molecular Structure 1292, pages 136187.
Crossref
Faiza Seraj, Khalid Mohammed Khan, Jamshed Iqbal, Aqeel Imran, Zahid Hussain, Uzma Salar, Shehryar Hameed & Muhammad Taha. (2023) Evaluation of synthetic aminoquinoline derivatives as urease inhibitors: in vitro , in silico and kinetic studies . Future Medicinal Chemistry 15:18, pages 1703-1717.
Crossref
Miraj Fatima, Samina Aslam, Ansa Madeeha Zafar, Ali Irfan, Misbahul Ain Khan, Muhammad Ashraf, Shah Faisal, Sobia Noreen, Gamal A. Shazly, Bakht Ramin Shah & Yousef A. Bin Jardan. (2023) Exploring the Synthetic Chemistry of Phenyl-3-(5-aryl-2-furyl)- 2-propen-1-ones as Urease Inhibitors: Mechanistic Approach through Urease Inhibition, Molecular Docking and Structure–Activity Relationship. Biomedicines 11:9, pages 2428.
Crossref
Saghi Sepehri & Mina Khedmati. (2023) An overview of the privileged synthetic heterocycles as urease enzyme inhibitors: Structure–activity relationship. Archiv der Pharmazie.
Crossref
Lamya H. Al-Wahaibi, Sivashanmugam Mangaiyarkarasi, Olivier Blacque, Hanan M. Hassan, Ali. A. El-Emam, M. Judith Percino & Subbiah Thamotharan. (2023) Unusual short intramolecular N–H⋅⋅⋅H–C contact and weak intermolecular interactions in two N-(adamantan-1-yl)piperazine carbothioamides: crystallography, quantum chemical study and in vitro urease inhibitory activity. Journal of Molecular Structure, pages 136052.
Crossref
Eliza K. Hanson & Rebecca J. Whelan. (2023) Application of the Nicoya OpenSPR to Studies of Biomolecular Binding: A Review of the Literature from 2016 to 2022. Sensors 23:10, pages 4831.
Crossref
Yan Tuo, Yuelu Tang, Yongxin Yu, Minghe Luo, Haoran Liang & Yuanqiang Wang. (2023) Structural optimization and binding energy prediction for globomycin analogs based on 3D-QSAR and molecular simulations. Journal of Molecular Structure 1279, pages 134981.
Crossref
Sadaf Rezvanpoor, Neda Shakour, Nazli Ahangarzadeh, Hamid Bakherad, Saghi Sepehri, Ghazaleh Farhadi, Mohammad Hosein Pakdel & Mehrdad Iranshahi. (2023) Synthesis, Biological Activity Evaluation, Docking and Molecular Dynamics Studies of New Triazole‐Tetrahydropyrimidinone(thione) Hybrid Scaffolds as Urease Inhibitors. Chemistry & Biodiversity 20:5.
Crossref
Rahul Singh, Parvin Kumar, Meena Devi, Jayant Sindhu, Ashwani Kumar, Sohan Lal, Devender Singh, Harish Kumar & Sumit Kumar. (2023) Urease Inhibition and Structure‐Activity Relationship Study of Thiazolidinone‐, Triazole‐, and Benzothiazole‐Based Heterocyclic Derivatives: A Focus Review. ChemistrySelect 8:13.
Crossref
Marciéli Fabris, Nailton M. Nascimento-Júnior, Marcelle L.F. Bispo & Priscila G. Camargo. (2023) Computational Strategies Targeting Inhibition of Helicobacter pylori and Cryptococcus neoformans Ureases. Current Pharmaceutical Design 29:10, pages 777-792.
Crossref
Y.-J. Han, Q.-R. Liu & L.-W. Xue. (2023) Synthesis, Characterization and Crystal Structures of Thiosemicarbazones with Urease Inhibitory Activity. Journal of Structural Chemistry 64:3, pages 462-473.
Crossref
Su-Ya Li, Yan Zhang, Yi-Ning Wang, Liang-Chao Yuan, Cui-Cui Kong, Zhu-Ping Xiao & Hai-Liang Zhu. (2023) Identification of (N-aryl-N-arylsulfonyl)aminoacetohydroxamic acids as novel urease inhibitors and the mechanism exploration. Bioorganic Chemistry 130, pages 106275.
Crossref
Zohreh Razmara, Hojat Samareh Delarami, Vaclav Eigner & Michal Dusek. (2022) Single crystal structure feature and quantum mechanical studies of a new binuclear Bi (III) complex and its activity against Helicobacter pylori. Inorganic Chemistry Communications 146, pages 110207.
Crossref
Wan-Qing Song, Mei-Ling Liu, Liang-Chao Yuan, Su-Ya Li, Yi-Ning Wang, Zhu-Ping Xiao & Hai-Liang Zhu. (2022) Synthesis, evaluation and mechanism exploration of 2-(N-(3-nitrophenyl)-N-phenylsulfonyl)aminoacetohydroxamic acids as novel urease inhibitors. Bioorganic & Medicinal Chemistry Letters 78, pages 129043.
Crossref
Yuke Zou, Rui Yan, Haibo Wang, Kai Zhong & Shuang Wang. (2022) NIR‐Responsive Polyurethane Nanocomposites Based on PDA@FA Nanoparticles with Synergistic Antibacterial Effect. Macromolecular Chemistry and Physics 223:19.
Crossref
Nazli Ahangarzadeh, Neda Shakour, Sadaf Rezvanpoor, Hamid Bakherad, Mohammad H. Pakdel, Ghazaleh Farhadi & Saghi Sepehri. (2022) Design, synthesis, and in silico studies of tetrahydropyrimidine analogs as urease enzyme inhibitors. Archiv der Pharmazie 355:10.
Crossref
J. Jiang, B. Liu, Y. Liu, C. Jing & Z. You. (2022) SYNTHESES, CRYSTAL STRUCTURES AND UREASE INHIBITORY ACTIVITIES OF ZnII AND NiII COMPLEXES DERIVED FROM 4,4′-DIMETHOXY-2,2′-(PROPANE-1,3- DIYLDIIMINODIMETHYLENE)DIPHENOL. Journal of Structural Chemistry 63:8, pages 1371-1381.
Crossref
Hina Siddiqui, Aaminat Qureshi, Majid Khan, Atia‐tul Wahab & Muhammad Iqbal Choudhary. (2022) Retracted: Functionalization of 2‐Amino‐4‐chloropyridine as Potential In Vitro Inhibitors of Urease Enzyme: Synthesis, Kinetics and In Silico Studies . ChemistrySelect 7:27.
Crossref
Aqsa Khalid, Nasima Arshad, Pervaiz Ali Channar, Aamer Saeed, Muhammad Ismail Mir, Qamar Abbas, Syeda Abida Ejaz, Tuncer Hökelek, Amna Saeed & Arfa Tehzeeb. (2022) Structure and surface analyses of a newly synthesized acyl thiourea derivative along with its in silico and in vitro investigations for RNR, DNA binding, urease inhibition and radical scavenging activities . RSC Advances 12:27, pages 17194-17207.
Crossref
Malena Cohen-Cymberknoh, Dror Kolodkin-Gal, Alona Keren-Paz, Shani Peretz, Vlad Brumfeld, Sergey Kapishnikov, Ronit Suissa, Michal Shteinberg, Daniel McLeod, Harsh Maan, Marianna Patrauchan, Gideon Zamir, Eitan Kerem & Ilana Kolodkin-Gal. (2022) Calcium carbonate mineralization is essential for biofilm formation and lung colonization. iScience 25:5, pages 104234.
Crossref
Ting Liu, Jian Liu, Jin He, Yu Hong, Han Zhou, Yin-Ling Liu & Shi Tang. (2022) Recent Advances in Photoinduced Perfluoroalkylation Using Perfluoroalkyl Halides as the Radical Precursors. Synthesis 54:08, pages 1919-1938.
Crossref
Hai-Lian Fang, Mei-Ling Liu, Su-Ya Li, Wan-Qing Song, Hui Ouyang, Zhu-Ping Xiao & Hai-Liang Zhu. (2022) Identification, potency evaluation, and mechanism clarification of α-glucosidase inhibitors from tender leaves of Lithocarpus polystachyus Rehd. Food Chemistry 371, pages 131128.
Crossref
Rabia Mehmood, Amina Sadiq, Reem I. Alsantali, Ehsan Ullah Mughal, Meshari A. Alsharif, Nafeesa Naeem, Asif Javid, Munirah M. Al-Rooqi, Gul-e-Saba Chaudhry & Saleh A. Ahmed. (2022) Synthesis and Evaluation of 1,3,5-Triaryl-2-Pyrazoline Derivatives as Potent Dual Inhibitors of Urease and α-Glucosidase Together with Their Cytotoxic, Molecular Modeling and Drug-Likeness Studies. ACS Omega 7:4, pages 3775-3795.
Crossref
Mei‐Ling Liu, Wei‐Yi Li, Hai‐Lian Fang, Ya‐Xi Ye, Su‐Ya Li, Wan‐Qing Song, Zhu‐Ping Xiao, Hui Ouyang & Hai‐Liang Zhu. (2021) Synthesis and Biological Evaluation of Dithiobisacetamides as Novel Urease Inhibitors. ChemMedChem 17:2.
Crossref
Wan-Qing Song, Mei-Ling Liu, Su-Ya Li & Zhu-Ping Xiao. (2022) Recent Efforts in the Discovery of Urease Inhibitor Identifications. Current Topics in Medicinal Chemistry 22:2, pages 95-107.
Crossref
Ishani P. Kalatuwawege, Medha J. Gunaratna & Dinusha N. Udukala. (2021) Synthesis, In Silico Studies, and Evaluation of Syn and Anti Isomers of N-Substituted Indole-3-carbaldehyde Oxime Derivatives as Urease Inhibitors against Helicobacter pylori. Molecules 26:21, pages 6658.
Crossref
Flavia Varano, Daniela Catarzi, Erica Vigiani, Diego Dal Ben, Michela Buccioni, Gabriella Marucci, Lorenzo Di Cesare Mannelli, Elena Lucarini, Carla Ghelardini, Rosaria Volpini & Vittoria Colotta. (2021) Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A1 and A2A Receptors, and Efficacy in Animal Models of Depression. Pharmaceuticals 14:7, pages 657.
Crossref
Asim Hussain, Nazish Jahan, Zara Jabeen, Khalil Ur Rehman, Hamza Rafeeq, Muhammad Bilal & Hafiz M. N. Iqbal. (2021) Synergistic Effect of Urease and Nitrification Inhibitors in the Reduction of Ammonia Volatilization. Water, Air, & Soil Pollution 232:7.
Crossref
Maria Stefania Sinicropi. (2021) Special Issue on “The Design, Synthesis and Biological Evaluation of Compounds with Medicinal Value”. Applied Sciences 11:4, pages 1904.
Crossref
Wei-Wei Ni, Hai-Lian Fang, Ya-Xi Ye, Wei-Yi Li, Chu-Ping Yuan, Dong-Dong Li, Shi-Jia Mao, Su-E Li, Qi-Hui Zhu, Hui Ouyang, Zhu-Ping Xiao & Hai-Liang Zhu. (2020) N -monosubstituted thiosemicarbazide as novel Ure inhibitors: synthesis, biological evaluation and molecular docking . Future Medicinal Chemistry 12:18, pages 1633-1645.
Crossref
Asad Hamad, Mohsin Abbas Khan, Khondaker Miraz Rahman, Irshad Ahmad, Zaheer Ul-Haq, Samra Khan & Zahid Shafiq. (2020) Development of sulfonamide-based Schiff bases targeting urease inhibition: Synthesis, characterization, inhibitory activity assessment, molecular docking and ADME studies. Bioorganic Chemistry 102, pages 104057.
Crossref
M. Ali, Assem Barakat, Ayman El-Faham, Abdullah Mohammed Al-Majid, Sammer Yousuf, Sajda Ashraf, Zaheer Ul-Haq, M. Iqbal Choudhary, Beatriz G. de la Torre & Fernando Albericio. (2020) Enamine Barbiturates and Thiobarbiturates as a New Class of Bacterial Urease Inhibitors. Applied Sciences 10:10, pages 3523.
Crossref
Tianyun Fan, Xixi Guo, Qingxuan Zeng, Wei Wei, Xuefu You, Jing Pang, Yanxiang Wang & Danqing Song. (2020) Synthesis and Structure–Activity Relationship of Palmatine Derivatives as a Novel Class of Antibacterial Agents against Helicobacter pylori. Molecules 25:6, pages 1352.
Crossref