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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Research Paper

Synthesis and characterisation of thiobarbituric acid enamine derivatives, and evaluation of their α-glucosidase inhibitory and anti-glycation activity

M. Alia Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia
,
Assem Barakata Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia;b Department of Chemistry, Faculty of Science, Alexandria University, Ibrahimia, EgyptCorrespondence[email protected]
,
Ayman El-Fahama Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia;b Department of Chemistry, Faculty of Science, Alexandria University, Ibrahimia, EgyptCorrespondence[email protected]
,
Hessa H. Al-Rasheeda Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia
,
Kholoud Dahlousa Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia
,
Abdullah Mohammed Al-Majida Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia
,
Anamika Sharmac Peptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa;d KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
,
Sammer Yousufe H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
,
Mehar Sanamf Dr. Panjwani Center for Molecular medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
,
Zaheer Ul-Haqf Dr. Panjwani Center for Molecular medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
,
M. Iqbal Choudharye H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan;f Dr. Panjwani Center for Molecular medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
,
Beatriz G. de la Torred KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
&
Fernando Albericioa Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia;c Peptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa;g CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, and Department of Organic Chemistry, University of Barcelona, Barcelona, Spain
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Pages 692-701 | Received 26 Dec 2019, Accepted 25 Feb 2020, Published online: 11 Mar 2020

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Poornima Devi, Abha Bishnoi, Vineeta Singh, Shraddha Shukla & Sonam Rai. (2023) A Compact Synthesis and Biological Evaluation of Biginilli Products of 1,3-Bis(3-Chlorophenyl)-2-Thioxodihydropyrimidine-4,6(1H,5H)-Dione. Polycyclic Aromatic Compounds 43:1, pages 131-140.
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Chenzhipeng Nie, Yan Li, Haifeng Qian, Hao Ying & Li Wang. (2022) Advanced glycation end products in food and their effects on intestinal tract. Critical Reviews in Food Science and Nutrition 62:11, pages 3103-3115.
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Atamjit Singh, Karanvir Singh, Aman Sharma, Komalpreet Kaur, Kirandeep Kaur, Renu Chadha & Preet Mohinder Singh Bedi. (2023) Recent developments in synthetic α-glucosidase inhibitors: A comprehensive review with structural and molecular insight. Journal of Molecular Structure 1281, pages 135115.
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Neetu Agrawal, Manisha Sharma, Shikha Singh & Ahsas Goyal. (2022) Recent Advances of α-Glucosidase Inhibitors: A Comprehensive Review. Current Topics in Medicinal Chemistry 22:25, pages 2069-2086.
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Umme Kulsoom, Uzma Salar, Khalid Mohammed Khan, Sridevi Chigurupati, Shazia Syed, Abdul Wadood, Ashfaq Ur Rehman, Bibi Fatima, Faiza Saleem, Muhammad Taha, Shatha Ghazi Felemban, Sudharshan Reddy Dachani & Shahnaz Perveen. (2022) Synthesis and evaluation of aryl aminomethylene substituted barbiturates and thiobarbiturates as novel α-amylase inhibitors and radical scavengers. Monatshefte für Chemie - Chemical Monthly 153:10, pages 949-960.
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Liang Xu, Lu Zhang, Yi‐hua Li, Li‐ya Li, Zuo‐hua Xie & Zong‐cai Tu. (2022) Inhibitory activity and mechanism of guavinoside B from guava fruits against α‐glucosidase: Insights by spectroscopy and molecular docking analyses. Journal of Food Biochemistry 46:7.
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Yang Hao, Tao Guo, Jinqi Ren, Yaxin Wang, Lei Wang, Yawei Shi & Wei Feng. (2022) Characterization of a thermostable, protease-tolerant inhibitor of α-glycosidase from carrot: A potential oral additive for treatment of diabetes. International Journal of Biological Macromolecules 209, pages 1271-1279.
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Narjes Hajali, Afshin Taghva Manesh & Ahmad Seif. (2021) Investigating Functionalization Impacts on Structural Features of Barbituric Acid Derivatives: DFT Approach. Main Group Chemistry 20:4, pages 529-537.
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Shaveer Ramkisson, Hessa H. Al‐Rasheed, Kholood A. Dahlous, Beatriz G. De La Torre, Ayman El‐Faham & Fernando Albericio. (2021) Scope and Limitations of Barbituric and Thiobarbituric Amino Acid Derivatives as Protecting Groups for Solid‐Phase Peptide Synthesis: Towards a Green Protecting Group. ChemistrySelect 6:26, pages 6626-6630.
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Furqan Ahmad Saddique, Sana Aslam, Matloob Ahmad, Usman Ali Ashfaq, Muhammad Muddassar, Sadia Sultan, Saman Taj, Muzammil Hussain, Dae Sung Lee & Magdi E. A. Zaki. (2021) Synthesis and α-Glucosidase Inhibition Activity of 2-[3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl]-N-arylacetamides: An In Silico and Biochemical Approach. Molecules 26:10, pages 3043.
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Saeed Alshahrani, Saied M. Soliman, Abdullah Saleh Alamary, Abdullah Mohammed Al-Majid, Matti Haukka, Sammer Yousuf & Assem Barakat. (2020) Synthesis of Enaminones-Based Benzo[d]imidazole Scaffold: Characterization and Molecular Insight Structure. Crystals 10:10, pages 955.
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Anamika Sharma, Assem Barakat, Hessa H. Al-Rasheed, Abdullah Mohammed Al-Majid, Sammer Yousuf, M. Iqbal Choudhary, Ayman El-Faham, Beatriz G. de la Torre & Fernando Albericio. (2020) Crystal Structure and Theoretical Investigation of Thiobarbituric Acid Derivatives as Nonlinear Optical (NLO) Materials. Crystals 10:6, pages 442.
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M. Ali, Assem Barakat, Ayman El-Faham, Abdullah Mohammed Al-Majid, Sammer Yousuf, Sajda Ashraf, Zaheer Ul-Haq, M. Iqbal Choudhary, Beatriz G. de la Torre & Fernando Albericio. (2020) Enamine Barbiturates and Thiobarbiturates as a New Class of Bacterial Urease Inhibitors. Applied Sciences 10:10, pages 3523.
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Assem Barakat, Saied M. Soliman, Matti Haukka, Abdullah Mohammed Al-Majid, Mohammad Shahidul Islam, M. Ali & Mohammed Rafi Shaik. (2020) One-Pot Synthesis, X-ray Single Crystal and Molecular Insight of Enaminone-Based β-Morpholino-/N-Methylpiperazinyl-/Pyrrolidinylpropiophenone. Crystals 10:4, pages 282.
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