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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Research Paper

The selenium-containing drug ebselen potently disrupts LEDGF/p75-HIV-1 integrase interaction by targeting LEDGF/p75

Da-Wei Zhanga Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou, ChinaORCID Iconhttps://orcid.org/0000-0001-5938-2603View further author information
ORCID Icon,
Hao-Li Yanb Center for Food and Drug Evaluation & Inspection of Henan, Zhengzhou, ChinaView further author information
,
Xiao-Shuang Xua Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou, ChinaView further author information
,
Lei Xua Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou, ChinaView further author information
,
Zhi-Hui Yinc First Hospital of Shanxi Medical University, Taiyuan, ChinaView further author information
,
Shan Changa Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou, ChinaView further author information
&
Heng Luod College of Life Sciences, South-Central University for Nationalities, Wuhan, ChinaCorrespondence[email protected]
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Pages 906-912 | Received 09 Jan 2020, Accepted 10 Mar 2020, Published online: 31 Mar 2020

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Dazhou Shi, Shujing Xu, Dang Ding, Kai Tang, Yang Zhou, Xiangyi Jiang, Shuo Wang, Xinyong Liu & Peng Zhan. (2023) Advances in drug structure-activity-relationships for the development of selenium-based compounds against HIV. Expert Opinion on Drug Discovery 0:0, pages 1-8.
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Chandan Sarkar, Mohnad Abdalla, Milon Mondal, Abul Bashar Ripon Khalipha & Nasir Ali. (2022) Ebselen suitably interacts with the potential SARS-CoV-2 targets: an in-silico approach. Journal of Biomolecular Structure and Dynamics 40:22, pages 12286-12301.
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Articles from other publishers (18)

Sunny Kumar, Malini Basu, Pratyasha Ghosh, Uttam Pal & Mrinal K. Ghosh. (2023) COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery. Genes & Diseases 10:4, pages 1402-1428.
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Pablo A. Nogara, Meire E. Pereira, Cláudia S. Oliveira, Laura Orian & João B. T. Rocha. (2023) Organic selenocompounds: are they the panacea for human illnesses?. New Journal of Chemistry 47:21, pages 9959-9988.
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Pankaj Musyuni, Ruchika Sharma & Geeta Aggarwal. (2023) Optimizing drug discovery: An opportunity and application with reverse translational research. Health Sciences Review 6, pages 100074.
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Alex Boateng, Masayuki Amano & Masaharu Sugiura. (2022) Synthesis of Selenoesters via Aldol Condensation and/or Conjugate Reduction and Their Antiviral Activities. ACS Omega 8:1, pages 1369-1374.
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Avtar Singh, Paramjit Singh, Rajeev Kumar & Ajeet Kaushik. (2022) Exploring nanoselenium to tackle mutated SARS-CoV-2 for efficient COVID-19 management. Frontiers in Nanotechnology 4.
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Paloma Begines, Sergio Martos, Irene Lagunes, Inés Maya, José M. Padrón, Óscar López & José G. Fernández-Bolaños. (2022) Chemoselective Preparation of New Families of Phenolic-Organoselenium Hybrids—A Biological Assessment. Molecules 27:4, pages 1315.
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Pablo A. Nogara, Cláudia S. Oliveira, Meire E. Pereira, Marco Bortoli, Laura Orian, Michael Aschner & João B.T. Rocha. 2022. Redox Chemistry and Biology of Thiols. Redox Chemistry and Biology of Thiols 643 677 .
Illya Aronskyy, Yosef Masoudi-Sobhanzadeh, Antonio Cappuccio & Elena Zaslavsky. (2021) Advances in the computational landscape for repurposed drugs against COVID-19. Drug Discovery Today 26:12, pages 2800-2815.
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Claudio Santi, Cecilia Scimmi & Luca Sancineto. (2021) Ebselen and Analogues: Pharmacological Properties and Synthetic Strategies for Their Preparation. Molecules 26:14, pages 4230.
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Raul Neri & Stefan H. Bossmann. (2021) Isoselenocyanates: Synthesis and Their Use for Preparing Selenium-Based Heterocycles. Synthesis 53:12, pages 2015-2028.
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Zemene Demelash Kifle, Akeberegn Gorems Ayele & Engidaw Fentahun Enyew. (2021) Drug Repurposing Approach, Potential Drugs, and Novel Drug Targets for COVID-19 Treatment. Journal of Environmental and Public Health 2021, pages 1-11.
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Cristina W. Nogueira, Nilda V. Barbosa & João B. T. Rocha. (2021) Toxicology and pharmacology of synthetic organoselenium compounds: an update. Archives of Toxicology 95:4, pages 1179-1226.
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Wesam Ali, Rosaria Benedetti, Jadwiga Handzlik, Clemens Zwergel & Cecilia Battistelli. (2021) The innovative potential of selenium-containing agents for fighting cancer and viral infections. Drug Discovery Today 26:1, pages 256-263.
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Zeger Debyser, Anne Bruggemans, Siska Van Belle, Julie Janssens & Frauke Christ. 2021. Antiviral Drug Discovery and Development. Antiviral Drug Discovery and Development 97 114 .
C.V. Haritha, Khan Sharun & Bosco Jose. (2020) Ebselen, a new candidate therapeutic against SARS-CoV-2. International Journal of Surgery 84, pages 53-56.
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Richa Vartak, Manali Patki, Suvidha Menon, Joseph Jablonski, Sonia Mediouni, Yige Fu, Susana T. Valente, Blase Billack & Ketan Patel. (2020) β-cyclodextrin polymer/Soluplus® encapsulated Ebselen ternary complex (EβpolySol) as a potential therapy for vaginal candidiasis and pre-exposure prophylactic for HIV. International Journal of Pharmaceutics 589, pages 119863.
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Jinsong Zhang, Ramy Saad, Ethan Will Taylor & Margaret P. Rayman. (2020) Selenium and selenoproteins in viral infection with potential relevance to COVID-19. Redox Biology 37, pages 101715.
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Helmut Sies & Michael J. Parnham. (2020) Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections. Free Radical Biology and Medicine 156, pages 107-112.
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