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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Research Paper

6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers

Laura Braconia NEUROFARBA Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, ItalyORCID Iconhttps://orcid.org/0000-0002-0861-0706View further author information
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Gianluca Bartoluccia NEUROFARBA Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, ItalyORCID Iconhttps://orcid.org/0000-0002-5631-8769View further author information
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Marialessandra Continob Department of Pharmacy-Drug Sciences, University of Bari “A. Moro”, Bari, ItalyORCID Iconhttps://orcid.org/0000-0002-0713-3151View further author information
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Niccolò Chiaramontea NEUROFARBA Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, ItalyORCID Iconhttps://orcid.org/0000-0003-1029-2118View further author information
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Roberta Giampietrob Department of Pharmacy-Drug Sciences, University of Bari “A. Moro”, Bari, ItalyORCID Iconhttps://orcid.org/0000-0002-2349-5224View further author information
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Dina Manettia NEUROFARBA Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, ItalyORCID Iconhttps://orcid.org/0000-0002-5881-6550View further author information
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Maria Grazia Perroneb Department of Pharmacy-Drug Sciences, University of Bari “A. Moro”, Bari, ItalyORCID Iconhttps://orcid.org/0000-0003-4195-5228View further author information
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Maria Novella Romanellia NEUROFARBA Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, ItalyORCID Iconhttps://orcid.org/0000-0002-5685-3403View further author information
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Nicola Antonio Colabufob Department of Pharmacy-Drug Sciences, University of Bari “A. Moro”, Bari, ItalyORCID Iconhttps://orcid.org/0000-0001-5639-7746View further author information
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Chiara Rigantic Department of Oncology, University of Turin, Turin, ItalyORCID Iconhttps://orcid.org/0000-0001-9787-4836View further author information
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Silvia Deia NEUROFARBA Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0898-7148View further author information
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Elisabetta Teodoria NEUROFARBA Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, ItalyORCID Iconhttps://orcid.org/0000-0002-9705-3875View further author information
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Pages 974-992 | Received 23 Dec 2019, Accepted 20 Mar 2020, Published online: 07 Apr 2020

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Faheem, Banoth Karan Kumar, Kondapalli Venkata Gowri Chandra Sekhar, Subhash Chander, Selvaraj Kunjiappan & Sankaranarayanan Murugesan. (2021) 1,2,3,4-Tetrahydroisoquinoline (THIQ) as privileged scaffold for anticancer de novo drug design. Expert Opinion on Drug Discovery 16:10, pages 1119-1147.
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Articles from other publishers (11)

Laura Braconi, Silvia Dei, Marialessandra Contino, Chiara Riganti, Gianluca Bartolucci, Dina Manetti, Maria Novella Romanelli, Maria Grazia Perrone, Nicola Antonio Colabufo, Stefano Guglielmo & Elisabetta Teodori. (2023) Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers. European Journal of Medicinal Chemistry 259, pages 115716.
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Shiwen Yu, Jinling Zheng, Yan Zhang, Dandan Meng, Yujue Wang, Xiaoyu Xu, Na Liang, Shayibai Shabiti, Xu Zhang, Zixi Wang, Zehua Yang, Pengbing Mi, Xing Zheng, Wenjun Li & Hongfei Chen. (2023) The mechanisms of multidrug resistance of breast cancer and research progress on related reversal agents. Bioorganic & Medicinal Chemistry 95, pages 117486.
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Chaoming Wang, Jinman Zhang, Xianfeng Wei, Mengke Yang, Weiping Ma, Rilei Yu, Ming Liu & Tao Jiang. (2023) Design, Synthesis, and Biological Evaluation of Marine Lissodendrins B Analogues as Modulators of ABCB1-Mediated Multidrug Resistance. Marine Drugs 21:5, pages 314.
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Chunyu Jiang, Ting Pan, Yunxiang Jiang, Zhiyu Zhang, Meifeng Zeng, Shuang Sun, Zheng Li, Yiqing Wu, Jingying Qiu, Mingshan Niu & Xiaoke Gu. (2023) Design and evaluation of dibenzoazepine-tetrahydroisoquinoline hybrids as potential P-glycoprotein inhibitors against multidrug resistant K562/A02 cells. European Journal of Medicinal Chemistry 249, pages 115150.
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Zhikun Yang, Xue Yang, Yasheng Li, Yue Cai, Yanlei Yu, Wenya Zhuang, Xuanrong Sun, Qingyong Li, Xiaoze Bao, Xinyi Ye, Jinmiao Tian, Bin Wei, Jianwei Chen, Qihao Wu, Huawei Zhang, Xiaozhou Mou & Hong Wang. (2023) Design, synthesis and biological evaluation of novel phenylfuran-bisamide derivatives as P-glycoprotein inhibitors against multidrug resistance in MCF-7/ADR cell. European Journal of Medicinal Chemistry 248, pages 115092.
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Elisabetta Teodori, Laura Braconi, Dina Manetti, Maria Novella Romanelli & Silvia Dei. (2022) The Tetrahydroisoquinoline Scaffold in ABC Transporter Inhibitors that Act as Multidrug Resistance (MDR) Reversers. Current Topics in Medicinal Chemistry 22:31, pages 2535-2569.
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Laura Braconi, Elisabetta Teodori, Marialessandra Contino, Chiara Riganti, Gianluca Bartolucci, Dina Manetti, Maria Novella Romanelli, Maria Grazia Perrone, Nicola Antonio Colabufo, Stefano Guglielmo & Silvia Dei. (2022) Overcoming Multidrug Resistance (MDR): Design, Biological Evaluation and Molecular Modelling Studies of 2,4‐Substituted Quinazoline Derivatives. ChemMedChem 17:12.
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Fabiana Subrizi, Yu Wang, Benjamin Thair, Daniel Méndez‐Sánchez, Rebecca Roddan, Max Cárdenas‐Fernández, Jutta Siegrist, Michael Richter, Jennifer N. Andexer, John M. Ward & Helen C. Hailes. (2021) Multienzyme One‐Pot Cascades Incorporating Methyltransferases for the Strategic Diversification of Tetrahydroisoquinoline Alkaloids. Angewandte Chemie International Edition 60:34, pages 18673-18679.
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Fabiana Subrizi, Yu Wang, Benjamin Thair, Daniel Méndez‐Sánchez, Rebecca Roddan, Max Cárdenas‐Fernández, Jutta Siegrist, Michael Richter, Jennifer N. Andexer, John M. Ward & Helen C. Hailes. (2021) Multienzyme One‐Pot Cascades Incorporating Methyltransferases for the Strategic Diversification of Tetrahydroisoquinoline Alkaloids. Angewandte Chemie 133:34, pages 18821-18827.
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Jessica Caciolla, Giovanna Picone, Giovanna Farruggia, Dario Valenti, Angela Rampa, Emil Malucelli, Federica Belluti, Alfonso Trezza, Ottavia Spiga, Stefano Iotti, Silvia Gobbi, Concettina Cappadone & Alessandra Bisi. (2021) Multifaceted activity of polyciclic MDR revertant agents in drug-resistant leukemic cells: Role of the spacer. Bioorganic Chemistry 106, pages 104460.
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Hang Zhang, Haiwei Xu, Charles R. AshbyJr.Jr., Yehuda G. Assaraf, Zhe‐Sheng Chen & Hong‐Min Liu. (2020) Chemical molecular‐based approach to overcome multidrug resistance in cancer by targeting P‐glycoprotein (P‐gp). Medicinal Research Reviews 41:1, pages 525-555.
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