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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Research Paper

1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy

Barbara Kaprońa Department of Clinical Genetics, I Faculty of Medicine with Dentistry Division, Medical University of Lublin, Lublin, PolandORCID Iconhttps://orcid.org/0000-0002-7520-3238View further author information
ORCID Icon,
Robert Czarnomysyb Department of Synthesis and Technology of Drugs, Faculty of Pharmacy, Medical University of Białystok, Bialystok, PolandView further author information
,
Mariusz Wysokińskic Department of Basic Nursing and Medical Teaching, Chair of Development in Nursing, Faculty of Health Sciences, Medical University of Lublin, Lublin, PolandView further author information
,
Rudolf Andrysd Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech RepublicView further author information
,
Kamil Musilekd Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech RepublicView further author information
,
Andrea Angelie Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, ItalyORCID Iconhttps://orcid.org/0000-0002-1470-7192View further author information
ORCID Icon,
Claudiu T. Supurane Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, ItalyORCID Iconhttps://orcid.org/0000-0003-4262-0323View further author information
ORCID Icon &
Tomasz Plechf Department of Pharmacology, Faculty of Health Sciences, Medical University of Lublin, Lublin, PolandCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8162-8435View further author information
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Pages 993-1002 | Received 04 Mar 2020, Accepted 23 Mar 2020, Published online: 07 Apr 2020

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Zijian Li, Yanle Men, Suhua Gao, Peipei Cui, Hongying Wang & Baoquan Chen. (2023) Design, synthesis, and antiproliferative investigation of novel quinazolinones incorporating 1,3,4-oxadiazole and 1,2,4-triazole thioether moieties. Phosphorus, Sulfur, and Silicon and the Related Elements 0:0, pages 1-9.
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Sümbül Yıldırım, Aslıhan Ayvaz, Arif Mermer & Fatih Kocabaş. (2023) Development of novel 1,2,4-triazole containing compounds with anticancer and potent anti-CB1 activity. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-12.
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Articles from other publishers (24)

Mitra Ghassemzadeh, Fatemeh Faghani, Saeed Shirkhani, Farshid Mohsenzadeh, Kioumars Aghapoor, Azar Tahghighi & Bernhard Neumüller. (2024) Novel cobalt(II) complex of a new 24-membered macrocyclic bis-Schiff base bearing 3-mercapto-1,2,4-triazole: Synthesis, characterization, thermal and biological investigations. Journal of Molecular Structure 1295, pages 136573.
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Umme Salma, Suhail Ahmad, Md. Zafer Alam & Salman A. Khan. (2023) A Review: Synthetic Approaches and Biological Applications of Triazole derivatives. Journal of Molecular Structure, pages 137240.
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Maoyi Dai, Yingying Zhang, Xiaoxiang Zhang, Ruiyi Wang, Wanxing Wei, Zhuan Zhang & Taoyuan Liang. (2023) Iodine-Mediated C2,3–H Aminoheteroarylation of Indoles. The Journal of Organic Chemistry 88:21, pages 15106-15117.
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Chih-Sheng Yang, Man-Chun Wu, Ming-Chi Lai, Sheng-Nan Wu & Chin-Wei Huang. (2023) Identification of New Antiseizure Medication Candidates in Preclinical Animal Studies. International Journal of Molecular Sciences 24:17, pages 13143.
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Ying Wang, Zheshan Quan & Dachuan Liu. (2023) An Active Group with Potential Anti-seizure Activity: A Review on 1,2,4- Triazoles. Letters in Drug Design & Discovery 20:8, pages 1005-1019.
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Yogeesha N. Nayak, Santosh L. Gaonkar & Mariya Sabu. (2023) Chalcones: Versatile intermediates in heterocyclic synthesis. Journal of Heterocyclic Chemistry 60:8, pages 1301-1325.
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Kinga Paruch, Barbara Kaproń, Jarogniew J. Łuszczki, Agata Paneth & Tomasz Plech. (2023) Effect of Linker Elongation on the VGSC Affinity and Anticonvulsant Activity among 4-Alkyl-5-aryl-1,2,4-triazole-3-thione Derivatives. Molecules 28:13, pages 5287.
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Mayursinh Zala, Jwalant J. Vora & Vijay M. Khedkar. (2023) Synthesis, Characterization, Antitubercular Activity, and Molecular Docking Studies of Pyrazolylpyrazoline-Clubbed Triazole and Tetrazole Hybrids. ACS Omega 8:23, pages 20262-20271.
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Sahithi Madireddy & Samskruthi Madireddy. (2023) Therapeutic Strategies to Ameliorate Neuronal Damage in Epilepsy by Regulating Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammation. Brain Sciences 13:5, pages 784.
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Waleed Abbas Jawad, Asim A. Balakit, Mahmoud Najim Abid Al-Jibouri, Yusuf Sert & Mohammed Obies. (2023) Design, synthesis, characterization, antioxidant, antiproliferative activity and molecular docking studies of new transition metal complexes of 1,2,4-triazole as combretastatin A-4 analogues. Journal of Molecular Structure 1274, pages 134437.
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Naheed Akhter, Sidra Batool, Samreen Gul Khan, Nasir Rasool, Fozia Anjum, Azhar Rasul, Şevki Adem, Sadaf Mahmood, Aziz ur Rehman, Mehr un Nisa, Zainib Razzaq, Jørn B. Christensen, Mohammed A. S. Abourehab, Syed Adnan Ali Shah & Syahrul Imran. (2023) Bio-Oriented Synthesis and Molecular Docking Studies of 1,2,4-Triazole Based Derivatives as Potential Anti-Cancer Agents against HepG2 Cell Line. Pharmaceuticals 16:2, pages 211.
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Chander, Monika, Akhilesh Kumar, Deepansh Sharma, Pawan K. Sharma & Sita Ram. (2023) Novel benzenesulfonamide bearing 1,2,4-triazoles as potent anti-microbial and anti-oxidant agents. Medicinal Chemistry Research.
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Hasti Amorzesh, Mohammad Bayat & Shima Nasri. (2022) Catalyst-free synthesis of highly functionalized triazole hexahydroquinoline carbohydrazide scaffolds via four-component cyclocondensation reaction. Molecular Diversity.
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Ravinder Kumar, Raj Kamal, Vipin Kumar & Prabhakar Chetti. (2022) Single crystal XRD, spectroscopic, DFT studies and synthesis of [1,2,4]triazolo[4,3-a]pyrimidines. Chemical Data Collections 42, pages 100949.
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Serghei Pogrebnoi, Oleg Radul, Eugenia Stingaci, Lucian Lupascu, Vladimir Valica, Livia Uncu, Anastasia Smetanscaia, Anthi Petrou, Ana Ćirić, Jasmina Glamočlija, Marina Soković, Athina Geronikaki & Fliur Z. Macaev. (2022) The Synthesis of Triazolium Salts as Antifungal Agents: A Biological and In Silico Evaluation. Antibiotics 11:5, pages 588.
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Mikolaj Krysa, Anna Makuch-Kocka, Katarzyna Susniak, Tomasz Plech, Marta Andres-Mach, Mirosław Zagaja & Anna Sroka-Bartnicka. (2022) Spectroscopic Evaluation of the Potential Neurotoxic Effects of a New Candidate for Anti-Seizure Medication—TP-315 during Chronic Administration (In Vivo). International Journal of Molecular Sciences 23:9, pages 4607.
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Anna Pachuta-Stec. (2022) Antioxidant Activity of 1,2,4-Triazole and its Derivatives: A Mini-Review. Mini-Reviews in Medicinal Chemistry 22:7, pages 1081-1094.
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Zahra Kazeminejad, Mahrokh Marzi, Abolfazl Shiroudi, Seyed Amin Kouhpayeh, Mojtaba Farjam & Elham Zarenezhad. (2022) Novel 1, 2, 4-Triazoles as Antifungal Agents. BioMed Research International 2022, pages 1-39.
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Shima Nasri, Mohammad Bayat & Khudaidad Kochia. (2021) Strategies for synthesis of 1,2,4-triazole-containing scaffolds using 3-amino-1,2,4-triazole. Molecular Diversity 26:1, pages 717-739.
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Yao Cheng, Yaru Cui, Yujie Zhai, Wenyu Xin, Yan Yu, Jia Liang, Shucui Li & Hongliu Sun. (2021) Neuroprotective Effects of Exogenous Irisin in Kainic Acid-Induced Status Epilepticus. Frontiers in Cellular Neuroscience 15.
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Monika Rola, Jakub Krassowski, Julita Górska, Anna Grobelna, Wojciech Płonka, Agata Paneth & Piotr Paneth. (2021) Machine Learning augmented docking studies of aminothioureas at the SARS-CoV-2—ACE2 interface. PLOS ONE 16:9, pages e0256834.
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Milenca Mariana Vorga & Valentin Badea. (2021) (±)-2-{[4-(4-Bromophenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}-1-phenyl-1-ethanol. Molbank 2021:3, pages M1268.
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Archana Archana. (2021) Synthesis of Novel Triazolyl/Oxadiazolyl/Thiadiazolyl-Piperazine as Potential Anticonvulsant Agents. Drug Research 71:04, pages 199-203.
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Ranjana Aggarwal & Garima Sumran. (2020) An insight on medicinal attributes of 1,2,4-triazoles. European Journal of Medicinal Chemistry 205, pages 112652.
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